Results 251 to 260 of about 4,450,920 (398)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
A streamlined guide RNA screening system for genome editing in Sorghum bicolor. [PDF]
Plant Methods, 2023 Lee JS, Bae SJ, Kim JS, Kim C, Kang BC.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A molecular proximity sensor based on an engineered, dual-component guide RNA. [PDF]
ElifeChoi J +4 more
europepmc +1 more source
Computational approaches for effective CRISPR guide RNA design and evaluation
Computational and Structural Biotechnology Journal, 2019 Guanqing Liu, Yong Zhang, Tao Zhang
semanticscholar +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Sensitive pathogen DNA detection by a multi-guide RNA Cas12a assay favoring trans- versus cis-cleavage. [PDF]
Nat CommunHuang Z +19 more
europepmc +1 more source
Spacer Fidelity Assessments of Guide RNA by Top-Down Mass Spectrometry. [PDF]
ACS Cent Sci, 2023 Macias LA +9 more
europepmc +1 more source