Results 251 to 260 of about 570,529 (349)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Single-guide RNA Cas9 and enhanced-deletion Cas9 rescue a recurrent <i>USH2A</i>-related splicing defect. [PDF]

Mol Ther Nucleic Acids
De Angeli P, Spaag S, Shliaga S, Flores-Tufiño A, Ritter M, Nasri M, Stingl K, Kühlewein L, Wissinger B, Kohl S.   +9 more
europepmc   +1 more source

Single Molecule FRET Analysis of CRISPR Cas9 Single Guide RNA Folding Dynamics. [PDF]

J Phys Chem B, 2023
Okafor IC, Ha T.
europepmc   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency. [PDF]

BMC Genomics
Lukasiak S, Kalinka A, Gupta N, Papadopoulos A, Saeed K, McDermott U, Hannon GJ, Ross-Thriepland D, Walter D.   +8 more
europepmc   +1 more source

Guide RNA acrobatics: the one-for-two shuffle. [PDF]

Genes Dev, 2022
Meier UT.
europepmc   +1 more source

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins [PDF]

, 2014
Sojung Kim, Daesik Kim, Seung Woo Cho, Jung‐Eun Kim, Jin‐Soo Kim   +4 more
openalex   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Intelligent guide RNA: dual toehold switches for modulating luciferase in the presence of trigger RNA. [PDF]

Commun Biol
Hashemabadi M, Sasan HA, Hosseinkhani S, Amandadi M, Samareh Gholami A, Sadeghizadeh M.   +5 more
europepmc   +1 more source

New Effective Method of Lactococcus Genome Editing Using Guide RNA-Directed Transposition. [PDF]

Int J Mol Sci, 2022
Pechenov PY, Garagulya DA, Stanovov DS, Letarov AV.   +3 more
europepmc   +1 more source