Results 171 to 180 of about 2,076,884 (287)

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

open access: yesAdvanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng   +7 more
wiley   +1 more source

Guided Bone Regeneration - A Review

open access: yesBiomedical and Pharmacology Journal, 2015
Priya Prabhakar   +1 more
openaire   +1 more source

Nanocatalytic Immunotherapy Targeting Tumor‐Resident Intracellular Bacteria for Triple‐Negative Breast Cancer Treatment and Metastasis Suppression

open access: yesAdvanced Science, EarlyView.
Bacteria residing within tumor cells contribute to breast cancer progression, but few therapies target their elimination. FeSe2 nanosheets coated with cancer cell membranes accumulate in tumors and generate reactive oxygen species under ultrasound, killing tumor cells and their harbored bacteria at the same time.
Xiaojing Leng   +8 more
wiley   +1 more source

composite biomaterials for bone repair

open access: yes, 2018
The fast replacement of native functionality (i.e., biological, chemical, mechanical) of damaged skeletal tissues currently represents the main challenge of clinical surgery.
Roberto De santis   +2 more
core  

Development‐Informed Microsphere Assemblies Enable Spatiotemporally Programmed Bone–Vascular Organoid‐Like Constructs for Large Bone Defect Repair

open access: yesAdvanced Science, EarlyView.
Single‐cell‐guided prioritization of BMP4 and VEGFA is combined with temporally programmed BMSCs and a Matrigel‐free GelMA/PEO/bioactive‐glass assembled‐microsphere matrix to generate bone–vascular organoid‐like constructs. The platform coordinates osteogenic differentiation, endothelial activation, vascular‐like microchannel formation, and ...
Renhao Ni   +14 more
wiley   +1 more source

A Citrulline‐Functionalized Patch Coordinates Macrophage NRF2 Signaling and Arginine Metabolism for Tendon‐to‐Bone Repair

open access: yesAdvanced Science, EarlyView.
A locally implanted patch combines citrulline‐functionalized carbon dots, a thioketal‐containing membrane coating from tendon‐derived stem cells, and aligned core–shell fibers. In macrophages, the patch reduces inflammatory markers and enhances antioxidant signaling through nuclear factor erythroid 2‐related factor 2 (NRF2); in rats and rabbits, it ...
Yuhao Yu   +13 more
wiley   +1 more source

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