Results 61 to 70 of about 462,681 (313)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Frammenti semantici. Riflessioni su descrizioni archivistiche e web semantico: Il caso dell’archivio Giovanni Testori [PDF]

, 2010
This doctoral thesis is about the possibility to put archival data (for example archival descriptions, authority records and so on) directly into semantic web, particularly using a technology called “Topic Maps”.
Vassallo, Salvatore
core  

Guidelines for the clinical management of familial adenomatous polyposis (FAP).

, 2008
Item does not contain fulltextBACKGROUND: Familial adenomatous polyposis (FAP) is a well-described inherited syndrome, which is responsible for
ALONSO A, Mecklin, J. P., Capella, G., Järvinen, H, S. Bulow, S. Tejpar, Moslein, G., Vasen, H F A, Renkonen-Sinisalo, L, Engel, C., NAGENGAST FM, BERTARIO L, A. Alonso, T. Myrhoi, Hes, F. J., Bertario, Lucio, Tejpar, S, Sampson, J. R., Hes, F J, P. Moller, F. M. Nagengast, Vasen, Hans, Engel, Christoph, Alonso, A, Capellá, G. (Gabriel), Burn, John, WIJNEN J., Tejpar, Sabine, Møller, Pål, Leon, M.P. de, J. Wijnen, C. Engel, Bülow, Steffen, Clark, S. K., Hes, Frederik J., ARETZ S, Clark, S K, Y. Parc, BERNSTEIN I, Bernstein, Inge Thomsen, G. Capella, Alonso, A., R. Phillips, Tejpar, S., STORMORKEN A, A. Stormorken, MYRHØI T, M. P. de Leon, BURN J, Vasen, H.F., Aretz, S., S. Aretz, Phillips, R., Myrhøi, T, Moller, P., de Leon, M. Ponz, Alonso, Albert, HODGSON S, Wijnen, J., I. Bernstein, Hodgson, S., J. R. Sampson, VASEN HF, Järvinen, Heikki, H. F. A. Vasen, FRIEDL W, Engel, C, THOMAS HJ, COLAS C, Bernstein, I., Capella, G, Bertario, L, Clark, Susan K., Thomas, H J W, W. Friedl, BÜLOW S, G. Moslein, Burn, J, H. Jarvinen, CLARK SK, Wijnen, J, Hodgson, S, Mecklin, J-P, J. Burn, Phillips, R, Ponz de Leon, M, Blanco Guillermo, Ignacio, Blanco, I, Bulow, S., JÄRVINEN H, Møller, P, Renkonen Sinisalo, Laura, Blanco, I., MECKLIN JP, RENKONEN SINISALO L, Nagengast, F.M., Stormorken, A, SAMPSON JR, S. Hodgson, F. J. Hes, Bertario, L., Friedl, W, Sampson, Julian Roy, I. Frayling, Bernstein, Inge, PARC Y, TEJPAR S, Myrhoi, T., Hodgson, Shirley, CAPELLA G, Möslein, Gabriela, BLANCO I, C. Colas, Thomas, H. J. W., FRAYLING I, L. Renkonen-Sinisalo, MÖSLEIN G, I. Blanco, Nagengast, F. M., Parc, Y., Sampson, J.R., Aretz, S, Thomas, H.J., Jarvinen, H., Frayling, Ian M., de Leon, M. P., Nagensgast, F M, Colas, C., Renkonen-Sinisalo, L., Hes, F.J., Parc, Y, Mecklin, Jukka-Pekka, Friedl, W., PHILLIPS R, Vasen, H. F. A., J.-P. Mecklin, L. Bertario, Ponz de Leon, Maurizio, Frayling, Ian, Möslein, G, Frayling, I, Clark, S.K., HES FJ, Mecklin, J.P., S. K. Clark, Colas, C, Colas, Chrystelle, Sampson, J R, Frayling, Ian Martin, Wijnen, Juul, Frayling, I., Parc, Yann, MØLLER P, Burn, J., Vasen, H. F. A, ENGEL C, Stormorken, A., Moeslein, G., H. J. W. Thomas   +158 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

How frequently should “living” guidelines be updated? Insights from the Australian Living Stroke Guidelines

, 2022
BACKGROUND: “Living guidelines” are guidelines which are continually kept up to date as new evidence emerges. Living guideline methods are evolving. The aim of this study was to determine how frequently searches for new evidence should be undertaken for ...
Wiles, Louise, McDonald, S., McDonald, Steve, Hill, Kelvin, Turner, Tari, English, Coralie, English, C., Hill, K., Wiles, L., Turner, T.   +9 more
core   +1 more source

A Guideline-Oriented Ontological Decision Support System for Diagnosis and Treatment of Urinary Incontinence (UrInO-DSS): A System Framework

Journal of Urological Surgery, 2023
Objective: To design an ontology-based clinical decision support system based on a clinical guideline for urinary incontinence.Materials and Methods:The study will be conducted in four phases: Updating the adapted clinical guideline for urinary ...
Fatemeh Sadeghi-Ghyassi, Shahla Damanabi, Leila R. Kalankesh, Stijn Van de Velde, Mohammad-Reza Feizi-Derakhshi, Sakineh Hajebrahimi   +5 more
doaj   +1 more source

Evidence-based (S3) guideline on topical corticosteroids in pregnancy

British Journal of Dermatology, 2011
Summary Women with skin conditions may need topical corticosteroids during pregnancy. However, little is known about the effects of topical corticosteroids on the fetus. A guideline subcommittee of the European Dermatology Forum was organized to develop an evidence-based guideline on the use of topical corticosteroids in pregnancy (http:/
Chi, C.C., Kirtschig, G., Aberer, W., Gabbud, J.P., Lipozencic, J., Karpati, S., Haustein, U.F., Zuberbier, T., Wojnarowska, F   +8 more
openaire   +4 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Practices and perceptions of 5-aminosalicylic acid use in Crohn’s disease: a nationwide survey of physicians in Korea by KASID Guidelines Taskforce Team [PDF]

Intestinal Research
Background/Aims Despite international guidelines recommending against the use of 5-aminosalicylic acid (5-ASA) for Crohn’s disease (CD), it remains widely prescribed.
June Hwa Bae, Seung Yong Shin, Dong Hyun Kim, Seung Min Hong, Eun Mi Song, Ji Eun Kim, Young Joo Yang, Jiyoung Yoon, Sang-Bum Kang, Eun Soo Kim, Sung Eun Kim, Seong-Jung Kim, Jun Lee, Soo-Young Na, Soo Jung Park, Sang Hyoung Park, Won Moon, Sung-Ae Jung,   +18 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source