Results 61 to 70 of about 1,528,496 (317)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Impact of using a local protocol in preoperative testing: blind randomized clinical trial.

Revista do Colégio Brasileiro de Cirurgiões
Objective: to evaluate the impact of the use of a local protocol of preoperative test requests in reducing the number of exams requested and in the occurrence of changes in surgical anesthetic management and perioperative complications.
MÔNICA LOUREIRO SANTOS, ANTÔNIO CARLOS IGLESIAS   +1 more
doaj   +1 more source

Practices and perceptions of 5-aminosalicylic acid use in Crohn’s disease: a nationwide survey of physicians in Korea by KASID Guidelines Taskforce Team [PDF]

Intestinal Research
Background/Aims Despite international guidelines recommending against the use of 5-aminosalicylic acid (5-ASA) for Crohn’s disease (CD), it remains widely prescribed.
June Hwa Bae, Seung Yong Shin, Dong Hyun Kim, Seung Min Hong, Eun Mi Song, Ji Eun Kim, Young Joo Yang, Jiyoung Yoon, Sang-Bum Kang, Eun Soo Kim, Sung Eun Kim, Seong-Jung Kim, Jun Lee, Soo-Young Na, Soo Jung Park, Sang Hyoung Park, Won Moon, Sung-Ae Jung,   +18 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Challenges and considerations in the management of acute pulmonary embolism: A critical analysis of European Society of Cardiology guidelines [PDF]

Vojnosanitetski Pregled
nema
Obradović Slobodan, Džudović Boris, Simpson Tamara   +2 more
doaj   +1 more source

Association between quality of clinical practice guidelines and citations given to their references

, 2013
It has been suggested that bibliometric analysis of different document types may reveal new aspects of research performance. In medical research a number of study types play different roles in the research process and it has been shown, that the evidence-
Andersen, Jens Peter
core  

Systematic development of an evidence-based website on preconception care [PDF]

, 2016
Introduction: In February 2015, the Flemish Minister of Welfare, Public Health and Family launched a website on preconception care: gezondzwangerworden.be'. The website was developed in response to the lack of comprehensive communication on preconception
Beeckman, Dimitri, De Steur, Hans, De Sutter, An, Delbaere, Ilse, Gellynck, Xavier, Mokangi, Pascale, Roelens, Kristien, van de Walle, Liselot, Vandenbulcke, Pieter   +8 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Writing a Case Report: A Work of Art

International Journal of Medical Students, 2015
Case reports are a time-honored, important, integral, accepted part firmly established within the medical literature, and represent a growing importance of valuable clinical medical information.
Christian Ortega-Loubon, Ricardo Correa-Márquez   +1 more
doaj  

Designing tailored maintenance strategies for systematic reviews and clinical practice guidelines using the Portfolio Maintenance by Test-Treatment (POMBYTT) framework

BMC Medical Research Methodology
Background Organizations face diverse contexts and requirements when updating and maintaining their portfolio, or pool, of systematic reviews or clinical practice guidelines they need to manage.
Michiel S. Oerbekke, Roy G. Elbers, Maarten J. van der Laan, Lotty Hooft   +3 more
doaj   +1 more source