Results 71 to 80 of about 1,528,496 (317)

Proposal for the implementation and monitoring of a health care nursing protocol for patients with external ventricular drains [PDF]

Revista Gaúcha de Enfermagem
Objective: To structure a proposal for implementing and monitoring the nursing care protocol for the safety of adult patients with external ventricular drains.
Sabrina Binkowski, Giovanna da Rosa Soares, Raphaela de Matos Borges, Tainara Wink Vieira, Victoria Tiyoko Moraes Sakamoto, Carine Raquel Blatt, Rita Catalina Aquino Caregnato   +6 more
doaj   +1 more source

Participation and consultation engagement strategies have complementary roles: A case study of patient and public involvement in clinical practice guideline development

Health Expectations, 2020
Background Patient and public involvement (PPI) is recommended when developing high‐quality clinical practice guidelines, but the effects of different PPI strategies are largely unstudied.
Melissa J. Armstrong, Gary S. Gronseth, Anna R. Gagliardi, C. Daniel Mullins   +3 more
doaj   +1 more source

The effect of the SAFE or SORRY? programme on patient safety knowledge of nurses in hospitals and nursing homes: a cluster randomised trial [PDF]

, 2010
Background: patients in hospitals and nursing homes are at risk for the development of often preventable adverse events. Guidelines for the prevention of many types of adverse events are available, however compliance with these guidelines appears to be ...
Betsie G.I. van Gaal, Brimmer, Campbell, Chan, Defloor, Defloor, Dutch Association of Nursing Home Physicians (NVVA), Dutch association of Nursing Home Physicians (NVVA), Dutch Institute for Healthcare Improvement [CBO], Dutch Workingparty on Infection Prevention (WIP), Dutch Workingparty on Infection Prevention (WIP), European Pressure Ulcer Advisory Panel (EPUAP), Farmer, Forsetlund, Freemantle, Gagnon, George F. Borm, Geriatric Nursing Association, Gillespie, Grimshaw, Grol, Grol, Grol, Gunningberg, Halfens, Hauer, Jamtvedt, Joke A.J. Mintjes, Lilian C.M. Vloet, Lisette Schoonhoven, O’Brien, Raymond T.C.M. Koopmans, Reeves, Schoonhoven, Schoonhoven, Schuster, Theo van Achterberg, Thomas, Van der Kolk, Van Gaal, Wallace, Wensing   +41 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Investigator-initiated versus industry-sponsored trials – visibility and relevance of randomized controlled trials in clinical practice guidelines (IMPACT)

BMC Medical Research Methodology
Background The goal of evidence-based medicine is to make clinical decisions based on the best available, relevant evidence. For this to be possible, studies such as randomized controlled trials (RCTs), which are widely considered to provide the best ...
Manuel Hecht, Anette Blümle, Harald Binder, Martin Schumacher, Nadine Binder   +4 more
doaj   +1 more source

Guidelines for Diagnosis and Treatment of Chronic Lymphocytic Leukemia. Krohem B-Cll 2017

Acta Clinica Croatica, 2018
Recent developments in the diagnosis and treatment of chronic lymphocytic leukemia (B-CLL) have led to change of approach in clinical practice. New treatments have been approved based on the results of randomized multicenter trials for first line and for
Branimir Jakšić, Vlatko Pejša, Slobodanka Ostojić-Kolonić, Ika Kardum-Skelin, Sandra Bašić-Kinda, Božena Coha, Velka Gverić-Krečak, Radovan Vrhovac, Ozren Jakšić, Igor Aurer, Jasminka Sinčić-Petričević, Antica Načinović-Duletić, Damir Nemet   +12 more
doaj   +1 more source

Postpartum Depression Screening of Women Veterans in Alaska Quality Improvement Project [PDF]

, 2017
A Project Submitted in Partial Fulfillment of the Requirements for the Degree of MASTER OF SCIENCE in Nursing SciencePostpartum depression screening guidelines were updated by the American College of Obstetricians and Gynecologists and the United ...
Brown, Elizabeth L.
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Evaluation of atrial fibrillation (AF) management and cardiovascular risk profile in AF patients: data from Turkish patients in the international observational cross-sectional REALISE AF trial

Türk Kardiyoloji Derneği Arşivi, 2015
Objectives: To assess control of atrial fibrillation (AF) and cardiovascular (CV) risk profile of AF patients with previously established AF therapies.
Erdem Diker, Gokmen Bellur, Nurten Yildiz, Cemil Izgi, Lisa Naditch-brûlé   +4 more
doaj   +1 more source