Activation of relaxin family receptor 1 from different mammalian species by relaxin peptide and small-molecule agonist ML290 [PDF]
, 2015 Relaxin peptide (RLN), which signals through the relaxin family peptide 1 (RXFP1) GPCR receptor, has shown therapeutic effects in an acute heart failure clinical trial.
Alexander I Agoulnik +12 more
core +3 more sources
Identification of atropine-and P2X1 receptor antagonist-reistant, neurogenic contractions of the urinary bladder [PDF]
, 2007 Acetylcholine and ATP are excitatory cotransmitters in parasympathetic nerves. We used P2X1 receptor antagonists to further characterize the purinergic component of neurotransmission in isolated detrusor muscle of guinea pig urinary bladder.
Gallagher, Gemma +3 more
core +1 more source
PLoS ONE, 2013 We investigated the guinea pig, Cavia porcellus, as a model for Alzheimer’s disease (AD), both in terms of the conservation of genes involved in AD and the regulatory responses of these to a known AD risk factor - high cholesterol intake. Unlike rats and
M. Sharman +10 more
semanticscholar +1 more source
The multidrug resistance 1 gene Abcb1 in brain and placenta: comparative analysis in human and guinea pig. [PDF]
PLoS ONE, 2014 The Multidrug Resistance 1 (MDR1; alternatively ABCB1) gene product P-glycoprotein (P-gp), an ATP binding cassette transporter, extrudes multiple endogenous and exogenous substrates from the cell, playing an important role in normal physiology and ...
Jane J Pappas +7 more
doaj +1 more source
Biomolecules, 2022 Intracellular Ca2+-mediated mechanisms for pacemaker depolarization were studied in sinus node tissue preparations from mice and guinea pigs. Microelectrode recordings revealed that the sinus node of the mouse, which had a higher beating rate, had a ...
Iyuki Namekata +5 more
doaj +1 more source
Functional evolution of the feeding system in rodents [PDF]
, 2012 The masticatory musculature of rodents has evolved to enable both gnawing at the incisors and chewing at the molars. In particular, the masseter muscle is highly specialised, having extended anteriorly to originate from the rostrum.
Cox, Philip G. +7 more
core +1 more source
Discovery of AZD3199, an inhaled ultralong acting β2 receptor agonist with rapid onset of action [PDF]
, 2014 A series of dibasic des-hydroxy β2 receptor agonists has been prepared and evaluated for potential as inhaled ultra-long acting bronchodilators. Determination of activities at the human β-adrenoreceptors demonstrated a series of highly potent and ...
Alcaraz L. +26 more
core +2 more sources
Identification of β2-adrenoceptors on guinea pig alveolar macrophages using (-)-3-[125I]iodocyanopindolol [PDF]
, 1990 The β-adrenoceptor antagonist (-)-3-[125I]iodocyanopindolol ([125I]ICYP) binds with high affinity and in a saturable way to membranes of guinea pig alveolar macrophages.
Amsterdam, J.G.C. (Jan) van +4 more
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FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTES
Journal of Experimental Medicine, 1973 Antigen activation of DNA synthesis in immune thymus-derived lymphocytes of guinea pigs requires the cooperation of macrophages and lymphocytes. We have investigated the role of histocompatibility determinants in this macrophage-lymphocyte interaction ...
A. Rosenthal, E. Shevach
semanticscholar +1 more source
Effect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig- to-rat xenotransplantation [PDF]
, 1995 In normal rats, the xenobiotic K76 inhibited the C5 and probably the C2 and C3 steps of complement and effectively depressed classical complement pathway activity, alternative complement pathway activity, and the C3 complement component during and well ...
Adachi +41 more
core +2 more sources