Results 31 to 40 of about 382,928 (314)

Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models

Scientific Reports, 2022
Asthma is a common respiratory disease associated with airway hyperresponsiveness (AHR), airway inflammation and mast cell (MC) accumulation in the lung. Monensin, an ionophoric antibiotic, has been shown to induce apoptosis of human MCs. The aim of this
Jielu Liu, Mu Nie, Caijuan Dong, Jesper Säfholm, Gunnar Pejler, Gunnar Nilsson, Mikael Adner   +6 more
doaj   +1 more source

Discovery of AZD3199, an inhaled ultralong acting β2 receptor agonist with rapid onset of action [PDF]

, 2014
A series of dibasic des-hydroxy β2 receptor agonists has been prepared and evaluated for potential as inhaled ultra-long acting bronchodilators. Determination of activities at the human β-adrenoreceptors demonstrated a series of highly potent and ...
Alcaraz L., Alikhani V., Anderson G. P., Austin R. P., Bao Y., Baur F., Bouyssou T., Cazzola M., Connolly S., Cooper A. E., Davies S. L., Deyrup M. D., Fuso L., Giles M. E., Green S. A, Kuna P., Matera M. G., Mortimer K. J., Patton J. S., Procopiou P. A., Procopiou P. A., Roig J., Stocks M. J., Tayab Z. R., Walker J. K. L., Walland A., White M. V.   +26 more
core   +2 more sources

ZOOMICS: Comparative Metabolomics of Red Blood Cells From Guinea Pigs, Humans, and Non-human Primates During Refrigerated Storage for Up to 42 Days

Frontiers in Physiology, 2022
Unlike other rodents, guinea pigs (Cavia porcellus) have evolutionarily lost their capacity to synthesize vitamin C (ascorbate) de novo and, like several non-human primates and humans, rely on dietary intake and glutathione-dependent recycling to cope ...
Lorenzo Bertolone, Hye Kyung H. Shin, Jin Hyen Baek, Yamei Gao, Steven L. Spitalnik, Paul W. Buehler, Paul W. Buehler, Angelo D’Alessandro, Angelo D’Alessandro   +8 more
doaj   +1 more source

Effect of anticomplement agent K-76 COOH in hamster-to-rat and guinea pig- to-rat xenotransplantation [PDF]

, 1995
In normal rats, the xenobiotic K76 inhibited the C5 and probably the C2 and C3 steps of complement and effectively depressed classical complement pathway activity, alternative complement pathway activity, and the C3 complement component during and well ...
Adachi, Anthony J. Demetris, Cochrane, Gewurz, Hasan, Hideaki Miyazawa, Hong, Iida, Kissmeyer-Nielsen, Kitano, Kitano, Leventhal, Minoru Nomoto, Mitsuko Tanaka, Miyagawa, Miyagawa, Miyazaki, Miyazaki, Miyazawa, Murase, Nelson, Noriko Murase, Ono, Perper, Pruitt, Pruitt, Qing Ye, Rafael Manez, Satoru Todo, Soares, Starzl, Starzl, Starzl, Starzl, Tanaka, Thomas E. Starzl, Valdivia, Van den Bogaerde, Wasei Miyazaki, Xia, Yamamoto, Yoichi Toyama   +41 more
core   +2 more sources

POLYMORPHISM OF THE ACINI IN SUBLINGUAL GLAND IN SOME SPECIES OF RODENTS - MORPHOLOGICAL STUDY

Agricultura, 2017
Salivary glands are a feature of terrestrial species, their structure being different depending on the species and diet. In special literature we did not found informations about the acini polymorphism in sublingual gland, therefore we consider it ...
Bianca Matosz, Flavia Ruxanda, C. Lațiu, Sidonia Bogdan, V. E. Luca, V. Miclăuș   +5 more
doaj   +1 more source

Guinea pigs sublethally infected with aerosolized Legionella pneumophila develop humoral and cell-mediated immune responses and are protected against lethal aerosol challenge. A model for studying host defense against lung infections caused by intracellular pathogens. [PDF]

, 1987
We have employed the guinea pig model of L. pneumophila infection, which mimics Legionnaires' disease in humans both clinically and pathologically, to study humoral and cell-mediated immune responses to L.
Breiman, RF, Horwitz, MA
core  

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Guinea pig breeding and its relation to sustainable food security and sovereignty in South America: nutrition, health, and production challenges

CyTA - Journal of Food
This review explores the economic impact and importance of guinea pig production for sustainable food security and sovereignty in South America. The ease of management, short reproductive cycles of 16 days, and profitability make guinea pig farming ...
Yamid Pinchao-Pinchao, Liliana Serna-Cock, Oswaldo Osorio-Mora, Diego F. Tirado   +3 more
doaj   +1 more source

A 2-D guinea pig lung proteome map

Data in Brief, 2015
Guinea pigs represent an important model for a number of infectious and non-infectious pulmonary diseases. The guinea pig genome has recently been sequenced to full coverage, opening up new research avenues using genomics, transcriptomics and proteomics ...
Simone Schuller, Kjell Sergeant, Jenny Renaut, John. J. Callanan, Caitriona Scaife, Jarlath E. Nally   +5 more
doaj   +1 more source

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuela Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source