Results 51 to 60 of about 135,352 (264)

Application of Isolated Guinea Pig Ileum Method for Detection of Histamine Substances in Osteopeptide Injections

Shiyan dongwu yu bijiao yixue, 2022
ObjectiveTo evaluate the detection of the histamine substances in osteopeptide injections by the isolated guinea pig ileum method, and to explore the feasibility of replacing cat depressor substances method.MethodsAccording to the 2020 edition of Chinese
WU Chang, LI Xiaojie, WU Yinnan, WANG Yao, WANG Yuxin, ZONG Weifeng, MENG Changhong, LU Yihong   +7 more
doaj   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

A qualitative study exploring concepts and attitudes of guinea pig producers in rural parishes of Pichincha, Ecuador: The need for a one health-one welfare approach to enhance production practices

One Health
With its compact size, resilience at high altitudes, and high feed efficiency, the guinea pig (Cavia porcellus) is a sustainable and high-quality protein option for people in resource restrictive areas of South America's Andean region.
Heather Fowler, Grace Faulkner, Gustavo Donoso, Oscar Fuentes, Monique Pairis-Garcia, Sarah Rhea   +5 more
doaj   +1 more source

Immunoglobulin genomics in the guinea pig (Cavia porcellus). [PDF]

PLoS ONE, 2012
In science, the guinea pig is known as one of the gold standards for modeling human disease. It is especially important as a molecular and cellular biology model for studying the human immune system, as its immunological genes are more similar to human ...
Yongchen Guo, Yonghua Bao, Qingwen Meng, Xiaoxiang Hu, Qingyong Meng, Liming Ren, Ning Li, Yaofeng Zhao   +7 more
doaj   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Development and Evaluation of a Direct Sandwich Enzyme-Linked Immunosorbent Assay for the Quantification of Guinea-Pig Immunoglobulin E

Journal of Pharmacological Sciences, 2006
.: The purpose of this study was to develop and evaluate a direct sandwich enzyme-linked immunosorbent assay (ELISA) for the immunoglobulin E (IgE) in serum and plasma from guinea pig using mouse monoclonal antibodies specific for guinea-pig IgE.
Nishimura Makoto, Funaoka Hiroyuki, Hosoe Hiroaki, Ohkaru Yasuhiko, Yakuo Ikuhisa, Hayakawa Shinobu, Ito Koji   +6 more
doaj   +1 more source

A Homolog Pentameric Complex Dictates Viral Epithelial Tropism, Pathogenicity and Congenital Infection Rate in Guinea Pig Cytomegalovirus. [PDF]

PLoS Pathogens, 2016
In human cytomegalovirus (HCMV), tropism to epithelial and endothelial cells is dependent upon a pentameric complex (PC). Given the structure of the placenta, the PC is potentially an important neutralizing antibody target antigen against congenital ...
Stewart Coleman, K Yeon Choi, Matthew Root, Alistair McGregor   +3 more
doaj   +1 more source

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Finite element analysis on the human and guinea pig cochlear vibration patterns under bone conduction stimulations

Scientific Reports
To compare the vibrational patterns of human and guinea pig cochleae accurately, we developed and validated a novel finite element model of the guinea pig, leveraging it to analyze vibrational patterns in the cochlea.
Mingduo Zhao, Stefan Stenfelt
doaj   +1 more source