Results 111 to 120 of about 1,632,982 (236)
Chronic kidney disease (CKD) has a high prevalence worldwide, with an increasing incidence. One of the mechanisms of CKD progression involves a disordered inter-organ relationship between the kidneys and the intestine, known as the kidney-gut axis.
Shu Wakino +4 more
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Advanced Science, EarlyView.GALK1 acts as a protein kinase beyond the phosphorylation of galactose. GALK1 phosphorylates TIMM13 at Y73 in the cytoplasm. This phosphorylation prevents premature oxidative folding of TIMM13 and ensures its entrance into the intermembrane space of mitochondrion, positively regulating mitochondrial respiration.
Chang Woo Ko +5 more
wiley +1 more source
Advanced Science, EarlyView.Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji +11 more
wiley +1 more source
Understanding the interplay between the gut-kidney axis in patients with chronic kidney disease
, 2023 People with kidney failure on dialysis, or have kidney transplant, experience severe and debilitating gastrointestinal (GI) symptoms reported in up to 88% of patients receiving maintenance dialysis and up to 50% in kidney transplant recipients. These are
Cooper, Tess Elsa
core
Lactate Signal: Modulator of Cellular Energy Production and Anabolism
Advanced Science, EarlyView.Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley +1 more source
TMAO is involved in kidney-yang deficiency syndrome diarrhea by mediating the “gut-kidney axis”
Background: Trimethylamine-N-oxide (TMAO) is a harmful metabolite dependent on the intestinal microbiota and excreted through the kidneys. According to numerous investigations, rich circulation concentrations of TMAO have been linked to kidney and ...
Leyao Fang +5 more
core +1 more source
Traditional Chinese medicine improved diabetic kidney disease through targeting gut microbiota
Pharmaceutical BiologyContext Diabetic kidney disease (DKD) affects nearly 40% of diabetic patients, often leading to end-stage renal disease that requires renal replacement therapies, such as dialysis and transplantation.
Xia-Qing Wu +6 more
doaj +1 more source
Advanced Science, EarlyView.Combined inhibition of the WDR5 WIN pocket and HDAC activity converts SAHA‐induced hyperacetylation into a promoter state with reduced WDR5–COMPASS association and H3K4me3. MYC/E2F‐linked nascent transcription and biosynthetic recovery are suppressed, while apoptosis and senescence‐like features increase, resulting in sustained growth inhibition in ...
Jintian Song +8 more
wiley +1 more source
Scientific ReportsAryl hydrocarbon receptor (AHR) is central to inter-organ and inter-organismal crosstalk along the gut microbiome-liver-kidney axis. Studies in the kidney indicate this is due its regulation of transporter-mediated "remote sensing and signaling" via ...
Neema Jamshidi, Sanjay K. Nigam
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Life-Course Programming of Kidney Disease: Roles of Gut Microbiota Dysbiosis and Oxidative Stress
AntioxidantsChronic kidney disease (CKD) affects millions globally and represents a major health burden. This narrative review adopts a life-course perspective to synthesize current evidence on CKD as a consequence of adverse early-life exposures that disrupt ...
Chien-Ning Hsu, You-Lin Tain
doaj +1 more source