Results 81 to 90 of about 1,632,982 (236)

SIRT3 deficiency aggravates renal injury and fibrosis in chronic kidney disease and is associated with intestinal barrier dysfunction and gut microbiota dysbiosis

Frontiers in Microbiology
BackgroundChronic kidney disease (CKD) is a progressive disorder characterized by persistent renal dysfunction, inflammation, and fibrosis. Sirtuin 3 (SIRT3), a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase, has been implicated in
Zhili Xiong, Zhili Xiong, Zhili Xiong, Zhili Xiong, Rong Qian, Rong Qian, Rong Qian, Rong Qian, Xiaoyu Zhang, Xiaoyu Zhang, Xiaoyu Zhang, Xiaoyu Zhang, Rui Wang, Rui Wang, Rui Wang, Rui Wang, Mengdi Cui, Mengdi Cui, Mengdi Cui, Mengdi Cui, Huiying Xiong, Huiying Xiong, Huiying Xiong, Huiying Xiong, Xue Tian, Xue Tian, Xue Tian, Xue Tian, Bing Guan, Bing Guan, Bing Guan, Bing Guan   +31 more
doaj   +1 more source

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Gut microbiota in chronic kidney disease-mineral and bone disorder: shared mechanisms, disease-specific signatures, and therapeutic prospects

Frontiers in Endocrinology
Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) is a systemic syndrome characterized by mineral metabolism disorders and impaired bone homeostasis.
Qianwei Wang, Zhicheng Zhou, Liang Pang, Yuchen Du, Xiaolong Li, Lijuan Dai   +5 more
doaj   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Investigating Gut Microbiota-Blood and Urine Metabolite Correlations in Early Sepsis-Induced Acute Kidney Injury: Insights from Targeted KEGG Analyses

, 2023
Sepsis-associated acute kidney injury (SA-AKI) is a life-threatening condition. This study employed metagenomics and metabolomics to analyze the gut microbiota and metabolites changes in nine patients, including four with SA-AKI and five without.
Yya Xu (14849437)
core   +1 more source

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

Gut microbiota and sepsis-associated acute kidney injury: a narrative review

Frontiers in Immunology
BackgroundSepsis-associated acute kidney injury (SA-AKI) carries high morbidity and mortality, yet its pathogenesis remains incompletely understood.
Hui Zhang, Hui Zhang, Bingling Fan, Ruze Ma, Ruze Ma, Ruowen Jiang, Ruowen Jiang, Zan Qin, Zan Qin, Xueping Qu, Xueping Qu, Junwu Wang, Junwu Wang, Jiawei Xue, Jiawei Xue, Caixia Wang, Caixia Wang, Xiaoqin Liu, Litao Guo, Litao Guo   +19 more
doaj   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source