Results 101 to 110 of about 2,342,108 (381)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

THE PLACE AND ROLE OF THE MANAGING AUTHORITY FOR OPERATIONAL PROGRAM FOR FISHERIES AND MARITIME AFFAIRS (AM-POPAM) IN THE ABSORPTION OF EUROPEAN FUNDS FOR THE PERIOD 2014-2020 [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2021
This article analyzes the activity carried out by the Managing Authority for Operational Program for Fisheries and Maritime Affairs (POPAM) within the Directorate General of Fisheries (AM-POPAM) in order to ensure the information and implementation ...
Sebastian GUT
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Shift Work: Gut Health and Metabolic Disease [PDF]

, 2020
The number of people engaged in shift work continues to rise, and with it the research linking shift work to various diseases and conditions. Shift work changes the body’s sleeping patterns and circadian rhythms which has an effect on all parts of the ...
Lane, Hailey
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

PD-1/PD-L1 Axis Downregulation in Guillain-Barré Syndrome: A Potential Mechanism Driving the Autoimmune Pathogenesis

International Journal of Infectious Diseases
Introduction: Guillain-Barré syndrome (GBS), an immune-mediated disorder of the peripheral nervous system characterized by progressive muscle weakness, is often triggered by Campylobacter jejuni infection. Molecular mimicry between C.
Mr Rasel Ahmed, Mrs Israt Jahan, Mrs Pritha Biswash, Miss Mehjabeen Haque, Miss Sarah Khurshid, Mr Jigishu Ahmed, Mr Sayed Akib Hossain, Dr Zhahirul Islam   +7 more
doaj   +1 more source

Discrimination of Supersymmetric Grand Unified Models in Gaugino Mediation

, 2011
We consider supersymmetric grand unified theory (GUT) with the gaugino mediated supersymmetry breaking and investigate a possibility to discriminate different GUT models in terms of predicted sparticle mass spectra.
Okada, Nobuchika, Tran, Hieu Minh
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients

Microbiology Spectrum
Multi-drug resistance (MDR) in Shigella continues to pose a significant public health challenge, particularly in developing countries. Recent advances in genomics strengthen the surveillance of MDR-pathogens and antimicrobial resistance (AMR) mediators ...
Asaduzzaman Asad, Md. Abu Jaher Nayeem, Md. Golam Mostafa, Ruma Begum, Shah Nayeem Faruque, Suraia Nusrin, Israt Jahan, Shoma Hayat, Zhahirul Islam   +8 more
doaj   +1 more source

The Reach of the Fermilab Tevatron and CERN LHC for Gaugino Mediated SUSY Breaking Models [PDF]

, 2001
In supersymmetric models with gaugino mediated SUSY breaking (inoMSB), it is assumed that SUSY breaking on a hidden brane is communicated to the visible brane via gauge superfields which propagate in the bulk.
A. Chamseddine, A. Pomarol, A.B. Lahanas, Alexander Belyaev, D. Pierce, D.E. Kaplan, E. Katz, G. Giudice, G.F. Giudice, H. Baer, H. Baer, H. Baer, H. Baer, H. Baer, H. Baer, H. Baer, H. Baer, H. Baer, H. Baer, H. Baer, H. Baer, H. Baer, H. Baer, H. Baer, Howard Baer, I. Jack, J. Hisano, J. Lykken, K. Matchev, K. Matchev, L. Randall, L.J. Hall, L.J. Hall, M. Carena, M. Dine, M. Schmaltz, M. Schmaltz, N. Polonsky, R. Arnowitt, R. Arnowitt, R. Barbieri, R. Demina, R. Hempfling, R. Rattazzi, S. Abdullin, S. Komine, S. Mrenna, S.P. Martin, Tadas Krupovnickas, V. Barger, V. Barger, W. de Boer, Xerxes Tata, Z. Chacko   +53 more
core   +2 more sources