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Sitagliptin ameliorates microbial dysbiosis and enhances gut barrier integrity in streptozotocin-induced type 2 diabetic rats. [PDF]
Chang Y +5 more
europepmc +1 more source
Adipose-derived stem cell extracellular vesicles attenuate liver fibrosis via restoration of gut barrier function and modulation of gut microbiota. [PDF]
Wu B, Guo J, Wang J, Feng J, Xu J.
europepmc +1 more source
Homeostasis of the gut barrier and potential biomarkers [PDF]
The gut barrier plays a crucial role by spatially compartmentalizing bacteria to the lumen through the production of secreted mucus and is fortified by the production of secretory IgA (sIgA) and antimicrobial peptides and proteins. With the exception of sIgA, expression of these protective barrier factors is largely controlled by innate immune ...
Jerry M Wells +2 more
exaly +9 more sources
Overview of the Importance of Biotics in Gut Barrier Integrity [PDF]
Increased gut permeability is suggested to be involved in the pathogenesis of a growing number of disorders. The altered intestinal barrier and the subsequent translocation of bacteria or bacterial products into the internal milieu of the human body induce the inflammatory state. Gut microbiota maintains intestinal epithelium integrity. Since dysbiosis
Aleksandra Maria Kocot +2 more
exaly +4 more sources
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Gut barrier disruption and chronic disease
Trends in Endocrinology and Metabolism, 2022The intestinal barrier protects the host against gut microbes, food antigens, and toxins present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic and extrinsic factors, including genetic predisposition, the Western diet, antibiotics, alcohol, circadian rhythm disruption, psychological stress, and aging. Chronic
Jan Martel +2 more
exaly +3 more sources
The gut barrier and chronic diseases
Current Opinion in Clinical Nutrition & Metabolic Care, 2022Purpose of review The purpose of this review is to provide an update regarding the gut barrier and its involvement with chronic diseases, as well as to review biomarkers for identification of gut barrier integrity. This review is timely and relevant as our knowledge is increasing regarding the role of the gut microbiome and the
Anthony, Santilli +2 more
openaire +2 more sources
Cell and Tissue Research, 2012
Serine proteases, cysteine proteases, aspartic proteases and matrix metalloproteinases play an essential role in extracellular matrix remodeling and turnover through their proteolytic action on collagens, proteoglycans, fibronectin, elastin and laminin.
Biancheri, Paolo +3 more
openaire +3 more sources
Serine proteases, cysteine proteases, aspartic proteases and matrix metalloproteinases play an essential role in extracellular matrix remodeling and turnover through their proteolytic action on collagens, proteoglycans, fibronectin, elastin and laminin.
Biancheri, Paolo +3 more
openaire +3 more sources
Journal of Clinical Gastroenterology, 2012
The intestinal barrier serves 2 critical functions for the survival of the individual: first, it allows nutrient absorption and second, it defends the body from dangerous macromolecule penetration. It is a complex multilayer system, consisting of an external "anatomic" barrier and an inner "functional" immunological barrier.
Scaldaferri, Franco +4 more
openaire +2 more sources
The intestinal barrier serves 2 critical functions for the survival of the individual: first, it allows nutrient absorption and second, it defends the body from dangerous macromolecule penetration. It is a complex multilayer system, consisting of an external "anatomic" barrier and an inner "functional" immunological barrier.
Scaldaferri, Franco +4 more
openaire +2 more sources

