Results 191 to 200 of about 1,048,386 (358)
Hierarchical Superposition Framework Reveals the Complex Effects of Natural Medicine Formulas
Advanced Intelligent Systems, EarlyView.A novel hierarchical superposition pharmacological model incorporates the principle of hierarchical structures from physics to simulate the spatiotemporal dynamics of drug combinations, to elucidate the universal law underlying drug combination effects. By modeling cross‐level causal transmission and attenuation, it advances beyond traditional additive
Weifeng Liang +3 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.This article describes the integration of compliant bi‐stability in continuum robots. This integration leads to two variants of compliant bistable mechanism (CBM) integrated continuum robot segments, extending and locking. Results show that when used together, these CBM‐integrated segments allow the continuum robot to form custom shapes.
Muhammad Umer Khan Niazi +4 more
wiley +1 more source
Altered Gut Flora Are Associated with Septic Complications and Death in Critically Ill Patients with Systemic Inflammatory Response Syndrome [PDF]
, 2010 Kentaro Shimizu +10 more
openalex +1 more source
AP2M1 Is a Candidate Gene for Microcephaly and Intellectual Disability in 3q27.1 Deletions
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Deletions of the 3q26.33q27.2 region appear to correlate with a distinct phenotype, although there are few reported cases. Here, we present seven previously unreported individuals carrying de novo 3q27 deletions (under 5 Mb), which include the AP2M1 (adaptor‐related protein complex 2, mu‐1 subunit) gene and summarize data from 12 previously ...
Russell Gear +16 more
wiley +1 more source
Carbon Black Nanoparticles Exposure Induces Intestinal Flora Dysbiosis and Consequent Activation of Gut-Liver Axis Leading to Liver Lipid Accumulation in Zebrafish [PDF]
, 2021 Qingqing Liu +4 more
openalex +1 more source
Animal Models and Experimental Medicine, EarlyView.BSN suppresses the cell viability of colorectal cancer by inducing GPX4‐regulated ferroptosis. BSN may bind to NRF2 protein to inactivate the NRF2 signaling, inhibiting the expression of p62 and HO‐1. Abstract Background Indole phytoalexins, plant‐derived compounds present in cruciferous vegetables, have demonstrated anticancer properties.
Shi‐Yuan Wen +5 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.In a study combining network pharmacological analysis and experimental verification, yunweiling has been shown improve functional constipation by inhibiting the PI3K‐Akt‐p53 signaling pathway and reducing the expression of TP53. Abstract Background This study investigated the impacts and mechanisms of yunweiling in the management of Functional ...
Peng Zhang +6 more
wiley +1 more source