Results 251 to 260 of about 156,706 (322)

Why we age

Biological Reviews, EarlyView.
ABSTRACT Three categories of explanations exist for why we age: mechanistic theories, which omit reference to evolutionary forces; weakening force of selection theories, which posit that barriers exist that prevent evolutionary forces from optimising fitness in ageing; and optimisation theories, which posit that evolutionary forces actually select for ...
Michael S. Ringel
wiley   +1 more source

RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target

Cancer Communications, EarlyView.
Abstract Background The role of N1‐methyladenosine (m1A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as a therapeutic target. Methods RNA m1A levels were assessed through liquid chromatography‐mass spectrometry.
Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su, Haiyun Shang, Hongyan Chen, Dan Huang, Qing Li, Jing Ren, Weixin Liu, Yifei Wang, Wei Kang, Jiabin Wu, Chi‐Chun Wong, Zongwei Cai, Matthew Tak Vai Chan, William Ka Kei Wu, Jun Yu, Huarong Chen   +18 more
wiley   +1 more source

Photodynamic therapy combined with immunotherapy effectively improved malignant gastric outlet obstruction in“immune-desert”gastric cancer by regulating tumor immune microenvironment and gut flora

Hao Chen
openalex   +1 more source

Chemical Composition, Antioxidant, and Antibacterial Activities of Mezilaurus duckei (Lauraceae)

Chemistry &Biodiversity, EarlyView.
ABSTRACT Mezilaurus duckei, a Brazilian endemic tree species found exclusively in the Amazon Rainforest, is primarily exploited for timber in construction. Due to its endangered status, this study aimed to investigate the chemical profile and biological properties of the ethanolic extract and its phases derived from M. duckei leaves. Chemical profiling
Bruna S. Moroto, Valéria S. Gonçalves, David J. Machate, Talita V. Freire, Érica L. Santos, Flávio M. Alves, Ana C. Micheletti, Nídia C. Yoshida   +7 more
wiley   +1 more source

Immunomodulatory Mechanisms of Tea Leaf Polysaccharide in Mice with Cyclophosphamide-Induced Immunosuppression Based on Gut Flora and Metabolomics. [PDF]

Foods
Zhou Q, Gao J, Sun X, Du J, Wu Z, Liang D, Ling C, Fang B.   +7 more
europepmc   +1 more source

Could the Biological Potency of Porcelia macrocarpa R.E. Fries (Annonaceae) be Linked to Its Diverse Metabolite Profile?

Chemistry &Biodiversity, EarlyView.
ABSTRACT Porcelia macrocarpa is a Brazilian plant species belonging to the Annonaceae family. To date, more than 190 compounds have been identified and/or isolated from this species, with terpenoids comprising the majority (62%). Alkaloids represent the second most abundant class (11%), followed by steroids (4%), acetogenins (4%), fatty acids (4 ...
Fernanda Thevenard, Ivanildo A. Brito, Emerson A. Oliveira, Mariana H. Chaves, João Henrique G. Lago   +4 more
wiley   +1 more source

Unraveling colorectal cancer prevention: The vitamin D - gut flora - immune system nexus. [PDF]

World J Gastrointest Oncol
Zhan ZS, Zheng ZS, Shi J, Chen J, Wu SY, Zhang SY.   +5 more
europepmc   +1 more source

The signature of the gut bacterial and fungal flora structure in Chinese children with Down’s syndrome

Qing Mu, Wei-Dong Yu, Minghui Li, Xinjuan Wang, Shimeng Ren, Xueyu Hou, Na Wu, Jingzhu Guo   +7 more
openalex   +1 more source

Probiotics Mediated Modulation of Gut-Flora Might Be a Biotherapeutical Approach for Obesity and Type 2 Diabetes

, 2011
Hariom Yadav, Shalini Jain, Francesco Marotta   +2 more
openalex   +1 more source