Results 101 to 110 of about 761,618 (380)

Gut microbiome alterations in Alzheimer’s disease

Scientific Reports, 2017
Alzheimer’s disease (AD) is the most common form of dementia. However, the etiopathogenesis of this devastating disease is not fully understood. Recent studies in rodents suggest that alterations in the gut microbiome may contribute to amyloid deposition,
Nicholas M. Vogt, R. Kerby, Kimberly A. Dill-McFarland, Sandra Harding, A. Merluzzi, Sterling C. Johnson, C. Carlsson, S. Asthana, H. Zetterberg, K. Blennow, B. Bendlin, F. Rey   +11 more
semanticscholar   +1 more source

Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake

Gut, 2020
Objectives This study aimed to explore the effects of an isocaloric Mediterranean diet (MD) intervention on metabolic health, gut microbiome and systemic metabolome in subjects with lifestyle risk factors for metabolic disease.
V. Meslier, M. Laiola, H. Roager, F. De Filippis, H. Roume, B. Quinquis, R. Giacco, I. Mennella, R. Ferracane, N. Pons, Edoardo Pasolli, A. Rivellese, L. Dragsted, P. Vitaglione, S. Ehrlich, D. Ercolini   +15 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The Association between the Firmicutes/Bacteroidetes Ratio and Body Mass among European Population with the Highest Proportion of Adults with Obesity: An Observational Follow-Up Study from Croatia

Biomedicines
Background/Objectives: The phyla Firmicutes and Bacteroidetes are the main constituents of the gut microbiota. An imbalance in the gut microbiota is a sign of dysbiosis, and the Firmicutes-to-Bacteroidetes ratio has been proposed to be a marker of it ...
Andrija Karačić, Ira Renko, Željko Krznarić, Sanja Klobučar, Ana-Marija Liberati Pršo   +4 more
doaj   +1 more source

Nuanced contribution of gut microbiome in the early brain development of mice

Gut Microbes, 2023
The complex symbiotic relationship between the mammalian body and gut microbiome plays a critical role in the health outcomes of offspring later in life.
Xin Yi Yeo, Woo Ri Chae, Hae Ung Lee, Han-Gyu Bae, Sven Pettersson, Joanes Grandjean, Weiping Han, Sangyong Jung   +7 more
doaj   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Extrachromosomal circular DNA as a novel biomarker for the progression of colorectal cancer

Molecular Medicine
Background Extrachromosomal circular DNA (eccDNA) has potential in tumor diagnosis, particularly for improving diagnostic accuracy and early cancer detection; however, many challenges remain in its application to clinical practice. Methods We conducted a
Quanpeng Qiu, Yi Ding, Xiaolong Guo, Jing Han, Jiaqi Zhang, Yaping Liu, Junjun She, Yinnan Chen   +7 more
doaj   +1 more source

MGMT activated by Wnt pathway promotes cisplatin tolerance through inducing slow-cycling cells and nonhomologous end joining in colorectal cancer

Journal of Pharmaceutical Analysis
Chemotherapy resistance plays a pivotal role in the prognosis and therapeutic failure of patients with colorectal cancer (CRC). Cisplatin (DDP)-resistant cells exhibit an inherent ability to evade the toxic chemotherapeutic drug effects which are ...
Haowei Zhang, Qixin Li, Xiaolong Guo, Hong Wu, Chenhao Hu, Gaixia Liu, Tianyu Yu, Xiake Hu, Quanpeng Qiu, Gang Guo, Junjun She, Yinnan Chen   +11 more
doaj   +1 more source

Microneedle‐Based Biofertilizer Delivery Improves Plant Growth Through Microbiome Engineering

Advanced Functional Materials, EarlyView.
This figure shows how microneedles are used to deliver biofertilizers to enhance plant growth through microbial migration, metabolic reprogramming, and changes in plant endogenous microbiome. Abstract This study presents a microneedle‐based system for the delivery of rhizospheric biofertilizers into plant tissues to enhance growth.
Zhicheng Le, Sevugan Mayalagu, Cheng‐Yen Chen, Raktim Bhattacharya, Abhishek Gupta, Jingyuan Li, Zhi Wei Norman Teo, Yufeng Shou, Arya Gopinath MP, Danni Zhong, Tedrick Thomas Salim Lew, Hao Yu, Naweed I. Naqvi, Sanjay Swarup, Andy Tay   +14 more
wiley   +1 more source

Dietary macronutrients and the gut microbiome: a precision nutrition approach to improve cardiometabolic health

Gut, 2022
Accumulating evidence indicates that the gut microbiome is an important regulator of body weight, glucose and lipid metabolism, and inflammatory processes, and may thereby play a key role in the aetiology of obesity, insulin resistance and type 2 ...
K. Jardon, E. Canfora, G. Goossens, E. Blaak   +3 more
semanticscholar   +1 more source