Results 81 to 90 of about 621,850 (267)

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Gut microbiome diversity is associated with sleep physiology in humans.

PLoS ONE, 2019
The human gut microbiome can influence health through the brain-gut-microbiome axis. Growing evidence suggests that the gut microbiome can influence sleep quality.
Robert P Smith, Cole Easson, Sarah M Lyle, Ritishka Kapoor, Chase P Donnelly, Eileen J Davidson, Esha Parikh, Jose V Lopez, Jaime L Tartar   +8 more
doaj   +1 more source

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Identification of Human Gut Microbiome Associated with Enterolignan Production

, 2022
Dietary plant lignans are converted inside the gut to enterolignans enterodiol (ED) and enterolactone (EL), which have several biological functions, and health benefits.
Nakagata, Takashi, Hosomi, Koji, Hitoshi Kawashima, Kenji Mizuguchi, Jun Kunisawa, Sawane, Kento, Nanri, Hinako, Ookoshi, Kouta, Takashi Nakagata, Hinako Nanri, Kento Sawane, Motohiko Miyachi, Kouta Ookoshi, Mohsen, Attayeb, Attayeb Mohsen, Park, Jonguk, Kawashima, Hitoshi, Jonguk Park, Koji Hosomi, Kunisawa, Jun, Chen, Yi-An, Mizuguchi, Kenji, Yi-An Chen, Miyachi, Motohiko   +23 more
core   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

Advanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang, Shijie He, Yuheng Chang, Sheng Mao, Jianan Canal Li, Binbin Chen, Hongxun Gao, Mingchun Xu, Chenxu Liu, Yajie Wang   +9 more
wiley   +1 more source

Lipidomic signatures reveal biomarkers of mild cognitive impairment

Translational Psychiatry
Mild cognitive impairment (MCI) is an early stage in the progression toward dementia. Lipids are central to neurodegeneration, yet the biomarker potential of lipidomics from saliva, plasma, and feces remains underexplored.
Jayashankar Jayaprakash, Siddabasave Gowda B. Gowda, Divyavani Gowda, MiaGB Consortium, Shalini Jain, Hariom Yadav, Shu-Ping Hui   +6 more
doaj   +1 more source

STUDYING THE GASTROINTESTINAL MICROBIOME OF A TRADITIONAL PERUVIAN COMMUNITY [PDF]

, 2018
The human gastrointestinal (GI) tract is an ecosystem that is home to a plethora of bacteria, archaea, microeukaryotes, and viruses, collectively termed the “gut microbiota” or “microbiome” when referring to the genetic material of the microbiota.
Patel, Nisha
core  

Research Progress of the Gut Microbiome in Hybrid Fish

, 2022
Fish, including hybrid species, are essential components of aquaculture, and the gut microbiome plays a vital role in fish growth, behavior, digestion, and immune health.
Zhang, Yongyong, Lifeng Zhu, Zhang, Qunde, Qinrong Zhang, Yongyong Zhang, Qunde Zhang, Zhang, Qinrong, Hua Chen, Xinyuan Cui, Guoqi Liu, Zhu, Lifeng, Liu, Guoqi, Chen, Hua, Cui, Xinyuan   +13 more
core   +1 more source