Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]
, 2020 Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher +8 more
core +1 more source
The role of the sex hormone-gut microbiome axis in tumor immunotherapy
Gut Microbes, 2023 Accumulating evidence suggested that both gut microbiome and sex play a critical role in the efficacy of immune checkpoint blockade therapy. Considering the reciprocal relationship between sex hormones and gut microbiome, the sex hormone-gut microbiome ...
Luoyang Wang +10 more
doaj +1 more source
Exercise, the Gut Microbiome, and Frailty [PDF]
Annals of Geriatric Medicine and Research, 2019 The gut microbiome is deeply associated with both skeletal muscle and brain function. In particular, gut microbiome dysbiosis may accelerate age-related diseases by affecting these systems.
Hyung Eun Shin +5 more
doaj +1 more source
Relationship between the gut microbiome and the development of colorectal cancer [PDF]
Yixue xinzhi zazhi, 2020 Colorectal cancer (CRC) is one of the leading cancers in the world. With the influence of westernized lifestyle, the morbidity and mortality of CRC are on the rise in China.
Yang-Ting HE, Li LIU
doaj +1 more source
Characterizing the gut microbiome in trauma: significant changes in microbial diversity occur early after severe injury. [PDF]
, 2017 Background:Recent studies have demonstrated the vital influence of commensal microbial communities on human health. The central role of the gut in the response to injury is well described; however, no prior studies have used culture-independent profiling
Calfee, Carolyn S +11 more
core +1 more source
Whole genome metagenomic analysis of the gut microbiome of differently fed infants identifies differences in microbial composition and functional genes, including an absent CRISPR/Cas9 gene in the formula-fed cohort [PDF]
, 2019 Background: Advancements in sequencing capabilities have enhanced the study of the human microbiome. There are limited studies focused on the gastro-intestinal (gut) microbiome of infants, particularly the impact of diet between breast-fed (BF) versus ...
Cox, Courtney +3 more
core +2 more sources
Gut microbiota in HIV-pneumonia patients is related to peripheral CD4 counts, lung microbiota, and in vitro macrophage dysfunction. [PDF]
, 2019 Pneumonia is common and frequently fatal in HIV-infected patients, due to rampant, systemic inflammation and failure to control microbial infection. While airway microbiota composition is related to local inflammatory response, gut microbiota has been ...
Byanyima, Patrick +14 more
core +2 more sources
Microorganisms, 2022 The precise mechanisms of action of the host’s gut microbiome at the level of its constituting bacteria are obscure in most cases despite its definitive role.
Chongkai Zhai +5 more
doaj +1 more source
Radiotherapy and the gut microbiome: facts and fiction
Radiation Oncology, 2021 An ever-growing body of evidence has linked the gut microbiome with both the effectiveness and the toxicity of cancer therapies. Radiotherapy is an effective way to treat tumors, although large variations exist among patients in tumor radio ...
Jing Liu, Chao Liu, Jinbo Yue
doaj +1 more source
Systematic Analysis of Impact of Sampling Regions and Storage Methods on Fecal Gut Microbiome and Metabolome Profiles. [PDF]
, 2020 The contribution of human gastrointestinal (GI) microbiota and metabolites to host health has recently become much clearer. However, many confounding factors can influence the accuracy of gut microbiome and metabolome studies, resulting in ...
Chang, Hang +10 more
core +1 more source