Results 11 to 20 of about 7,489 (208)

Antibiotic Treatment Drives the Diversification of the Human Gut Resistome [PDF]

Genomics, Proteomics & Bioinformatics, 2019
Despite the documented antibiotic-induced disruption of the gut microbiota, the impact of antibiotic intake on strain-level dynamics, evolution of resistance genes, and factors influencing resistance dissemination potential remains poorly understood.
Jun Li, Elizabeth A. Rettedal, Eric van der Helm, Mostafa Ellabaan, Gianni Panagiotou, Morten O.A. Sommer   +5 more
doaj   +5 more sources

Human Gut Antibiotic Resistome and Progression of Diabetes [PDF]

Advanced Science, 2022
The antibiotic resistance crisis underlies globally increasing failures in treating deadly bacterial infections, largely due to the selection of antibiotic resistance genes (ARG) collection, known as the resistome, in human gut microbiota. So far, little
Menglei Shuai, Guoqing Zhang, Fang‐fang Zeng, Yuanqing Fu, Xinxiu Liang, Ling Yuan, Fengzhe Xu, Wanglong Gou, Zelei Miao, Zengliang Jiang, Jia‐ting Wang, Lai‐bao Zhuo, Yu‐ming Chen, Feng Ju, Ju‐Sheng Zheng   +14 more
doaj   +3 more sources

Resistome expansion in disease-associated human gut microbiomes

Microbiome, 2023
Background The resistome, the collection of antibiotic resistance genes (ARGs) in a microbiome, is increasingly recognised as relevant to the development of clinically relevant antibiotic resistance.
Simen Fredriksen, Stef de Warle, Peter van Baarlen, Jos Boekhorst, Jerry M. Wells   +4 more
doaj   +4 more sources

Gut resistome linked to sexual preference and HIV infection

BMC Microbiology, 2023
Background People living with HIV (PLWH) are at increased risk of acquisition of multidrug resistant organisms due to higher rates of predisposing factors.
Elisa Rubio Garcia, Maria Casadellà, Mariona Parera, Jordi Vila, Roger Paredes, Marc Noguera-Julian   +5 more
doaj   +6 more sources

Carbendazim shapes microbiome and enhances resistome in the earthworm gut

Microbiome, 2022
Background It is worrisome that several pollutants can enhance the abundance of antibiotic resistance genes (ARGs) in the environment, including agricultural fungicides. As an important bioindicator for environmental risk assessment, earthworm is still a
Jiajin Song, Tongxin Li, Zhiruo Zheng, Wenjie Fu, Zhengnan Long, Nan Shi, Yuling Han, Luqing Zhang, Yunlong Yu, Hua Fang   +9 more
doaj   +3 more sources

The effects of antibiotic exposures on the gut resistome during hematopoietic cell transplantation in children [PDF]

Gut Microbes
Antibiotic resistance is a global threat driven primarily by antibiotic use. We evaluated the effects of antibiotic exposures on the gut microbiomes and resistomes of children at high risk of colonization by antibiotic-resistant bacteria.
Sarah M. Heston, Rebecca R. Young, Kirsten Jenkins, Paul L. Martin, Andre Stokhuyzen, Doyle V. Ward, Shakti K. Bhattarai, Vanni Bucci, Mehreen Arshad, Nelson J. Chao, Patrick C. Seed, Matthew S. Kelly   +11 more
doaj   +2 more sources

The Human Gut Resistome up to Extreme Longevity. [PDF]

mSphere, 2021
Antibiotic resistance is widespread among different ecosystems, and in humans it plays a key role in shaping the composition of the gut microbiota, enhancing the ecological fitness of certain bacterial populations when exposed to antibiotics. A considerable component of the definition of healthy aging and longevity is associated with the structure of ...
Tavella T, Turroni S, Brigidi P, Candela M, Rampelli S.   +4 more
europepmc   +5 more sources

Age- and diet-driven assembly of the gut antibiotic resistome in humans and food-producing animals [PDF]

Gut Microbes
Antimicrobial resistance (AMR) poses a growing threat to global health, and increasing evidence reveals a substantial overlap in resistance genes between the gut microbiota of humans and food-producing animals, suggesting potential for cross-species ...
Tao Zhang, Jing Wang, Qingying Feng, Xinming Xu, Weiyun Zhu, Shengyong Mao, Jinxin Liu   +6 more
doaj   +2 more sources

Evolution of the murine gut resistome following broad-spectrum antibiotic treatment. [PDF]

Nat Commun, 2022
AbstractThe emergence and spread of antimicrobial resistance (AMR) represent an ever-growing healthcare challenge worldwide. Nevertheless, the mechanisms and timescales shaping this resistome remain elusive. Using an antibiotic cocktail administered to a murine model along with a longitudinal sampling strategy, we identify the mechanisms by which gut ...
de Nies L, Busi SB, Tsenkova M, Halder R, Letellier E, Wilmes P.   +5 more
europepmc   +5 more sources

The human gut resistome: Current concepts & future prospects. [PDF]

Indian J Med Res, 2019
The human gut is home to a myriad of organisms. While some are harmless commensals, others are transient, pathogenic flora. The gut microbiome is composed of diverse bacterial flora, and apart from playing a major role in protecting from various infectious and non-infectious diseases, it plays an important role in resistance ...
Singh S, Verma N, Taneja N.
europepmc   +3 more sources