Results 21 to 30 of about 7,489 (208)

Gut resistome of NSCLC patients treated with immunotherapy. [PDF]

Front Genet
BackgroundThe newest method of treatment for patients with NSCLC (non-small cell lung cancer) is immunotherapy directed at the immune checkpoints PD-1 (Programmed Cell Death 1) and PD-L1 (Programmed Cell Death Ligand 1). PD-L1 is the only validated predictor factor for immunotherapy efficacy, but it is imperfect.
Iwan E, Grenda A, Bomba A, Bielińska K, Wasyl D, Kieszko R, Rolska-Kopińska A, Chmielewska I, Krawczyk P, Rybczyńska-Tkaczyk K, Olejnik M, Milanowski J.   +11 more
europepmc   +5 more sources

Dynamics of gut resistome and mobilome in early life: a meta-analysis. [PDF]

EBioMedicine
The gut microbiota of infants harbours a higher proportion of antibiotic resistance genes (ARGs) compared to adults, even in infants never exposed to antibiotics. Our study aims to elucidate this phenomenon by analysing how different perinatal factors influence the presence of ARGs, mobile genetic elements (MGEs), and their bacterial hosts in the ...
Bargheet A, Noordzij HT, Ponsero AJ, Jian C, Korpela K, Valles-Colomer M, Debelius J, Kurilshikov A, Pettersen VK.   +8 more
europepmc   +5 more sources

Tetracycline Resistome of the Organic Pig Gut [PDF]

Applied and Environmental Microbiology, 2009
ABSTRACT The occurrence of genes conferring resistance to tetracyclines in the organic pig gut was assessed through the metagenomic approach. Of 9,000 bacterial artificial chromosome clones analyzed, 10 were identified as carrying the known tet (C), tet (W), and tet
Katarzyna A, Kazimierczak, Karen P, Scott, Denise, Kelly, Rustam I, Aminov   +3 more
openaire   +2 more sources

Household environment and animal fecal contamination are critical modifiers of the gut microbiome and resistome in young children from rural Nicaragua

Microbiome, 2023
Background Early life plays a vital role in the development of the gut microbiome and subsequent health. While many factors that shape the gut microbiome have been described, including delivery mode, breastfeeding, and antibiotic use, the role of ...
Molly Mills, Seungjun Lee, Barbara A. Piperata, Rebecca Garabed, Boseung Choi, Jiyoung Lee   +5 more
doaj   +1 more source

Destination shapes antibiotic resistance gene acquisitions, abundance increases, and diversity changes in Dutch travelers

Genome Medicine, 2021
Background Antimicrobial-resistant bacteria and their antimicrobial resistance (AMR) genes can spread by hitchhiking in human guts. International travel can exacerbate this public health threat when travelers acquire AMR genes endemic to their ...
Alaric W. D’Souza, Manish Boolchandani, Sanket Patel, Gianluca Galazzo, Jarne M. van Hattem, Maris S. Arcilla, Damian C. Melles, Menno D. de Jong, Constance Schultsz, COMBAT Consortium, Gautam Dantas, John Penders   +11 more
doaj   +1 more source

Metagenomic Insights into Chicken Gut Antibiotic Resistomes and Microbiomes

Microbiology Spectrum, 2022
The prevalence of antibiotic resistance genes in the chicken gut environment poses a serious threat to human health; however, we lack a comprehensive exploration of antibiotic resistomes and microbiomes in the chicken gut environment. The results of this study demonstrate the diversity and abundance of antibiotic resistance genes and flora in the ...
Jintao Yang, Cuihong Tong, Danyu Xiao, Longfei Xie, Ruonan Zhao, Zhipeng Huo, Ziyun Tang, Jie Hao, Zhenling Zeng, Wenguang Xiong   +9 more
openaire   +3 more sources

Does reduced usage of antibiotics in livestock production mitigate the spread of antibiotic resistance in soil, earthworm guts, and the phyllosphere? [PDF]

, 2020
The overuse of antibiotics in animal husbandry is widespread and believed to significantly contribute to the selection of antibiotic resistance genes (ARGs) in animals.
Daniell, Tim, Giles, Madeline, Neilson, Roy, Yang, Xiao-Ru, Zhou, Shu-Yi-Dan, Zhu, Dong   +5 more
core   +3 more sources

ResistoMap—online visualization of human gut microbiota antibiotic resistome [PDF]

Bioinformatics, 2016
Abstract We created ResistoMap—a Web-based interactive visualization of the presence of genetic determinants conferring resistance to antibiotics, biocides and heavy metals in human gut microbiota. ResistoMap displays the data on more than 1500 published gut metagenomes of world populations including both healthy subjects and patients.
Yarygin, Konstantin, Kovarsky, Boris, Bibikova, Tatyana, Melnikov, Damir, Tyakht, Alexander, Alexeev, Dmitry   +5 more
openaire   +2 more sources

Prevalence of Antibiotic Resistome in Ready-to-Eat Salad [PDF]

, 2020
Ready-to-eat salad harbors microorganisms that may carry various antibiotic resistance genes (ARGs). However, few studies have focused on the prevalence of ARGs on salad, thus underestimating the risk of ARGs transferring from salad to consumers. In this
Giles, Madeline, Neilson, Roy, Wei, Meng-Yun, Yang, Xiao-Ru, Zhang, Qi, Zheng, Fei, Zhou, Shu-Yi-Dan, Zhu, Yong-Guan   +7 more
core   +2 more sources

Interkingdom Gut Microbiome and Resistome of the Cockroach Blattella germanica

mSystems, 2021
For the first time, we analyze the interkingdom hindgut microbiome of this species, including bacteria, fungi, archaea, and viruses. Network analysis reveals putative cooperation between core bacteria that could be key for ecosystem equilibrium.
Rebeca Domínguez-Santos, Ana Elena Pérez-Cobas, Paolo Cuti, Vicente Pérez-Brocal, Carlos García-Ferris, Andrés Moya, Amparo Latorre, Rosario Gil   +7 more
openaire   +7 more sources