A reservoir of 'historical' antibiotic resistance genes in remote pristine Antarctic soils [PDF]
Background: Soil bacteria naturally produce antibiotics as a competitive mechanism, with a concomitant evolution, and exchange by horizontal gene transfer, of a range of antibiotic resistance mechanisms.
Bezuidt, Oliver KI +5 more
core +2 more sources
Tetracycline-like resistome of ancient human guts
Abstract Tetracyclines were discovered over 70 years ago and their use resulted in the emergence of tetracycline-resistance microorganisms; however, it has been hypothesized that tetracycline-resistance may have originated in the environment, and that determinants were transferred to the human gut microbiota.
Stefania Luciani +9 more
openaire +2 more sources
Analysis of 1135 gut metagenomes identifies sex-specific resistome profiles [PDF]
Several gastrointestinal diseases show a sex imbalance, although the underlying (patho)physiological mechanisms behind this are not well understood. The gut microbiome may be involved in this process, forming a complex interaction with host immune system, sex hormones, medication and other environmental factors.
Sinha, Trishla +16 more
openaire +5 more sources
A reference gene catalogue of chicken gut antibiotic resistomes [PDF]
Abstract Background: The chicken gut microbiota, as a reservoir of antibiotic resistance genes (ARGs), poses a high risk to humans and animals worldwide. Yet a comprehensive exploration of the chicken gut antibiotic resistomes remains incomplete.
Jintao Yang +9 more
openaire +1 more source
Country-specific antibiotic use practices impact the human gut resistome [PDF]
Despite increasing concerns over inappropriate use of antibiotics in medicine and food production, population-level resistance transfer into the human gut microbiota has not been demonstrated beyond individual case studies. To determine the “antibiotic resistance potential” for entire microbial communities, we employ metagenomic data and quantify the ...
Forslund, Kristoffer +6 more
openaire +4 more sources
The gut microbiome and resistome of conventionally vs. pasture-raised pigs
Conventional swine production typically houses pigs indoors and in large groups, whereas pasture-raised pigs are reared outdoors at lower stocking densities. Antimicrobial use also differs, with conventionally raised pigs often being exposed to antimicrobials directly or indirectly to control and prevent infectious disease. However,
Devin B. Holman +2 more
openaire +2 more sources
The prevalence of antibiotic-resistant bacteria in Southeast Asia is a significant concern, yet there is limited research on the gut resistome and its correlation with lifestyle and environmental factors in the region. This study aimed to profile the gut
J. Dwiyanto +8 more
doaj +1 more source
Draft Genome Sequences of Antibiotic-Resistant Commensal Escherichia coli [PDF]
Antimicrobial resistance is a significant public health issue. We report here the draft genome sequences of three drug-resistant strains of commensal Escherichia coli isolated from a single healthy college student.
Garrett, Meghan +2 more
core +2 more sources
Antibiotic perturbation of the preterm infant gut microbiome and resistome [PDF]
The gut microbiota plays important roles in nutrient absorption, immune system development, and pathogen colonization resistance. Perturbations early in life may be detrimental to host health in the short and the long-term. Antibiotics are among the many factors that influence the development of the microbiota.
Andrew J, Gasparrini +5 more
openaire +2 more sources
From the microbiome to the central nervous system, an update on the epidemiology and pathogenesis of bacterial meningitis in childhood [version 1; referees: 3 approved] [PDF]
In the past century, advances in antibiotics and vaccination have dramatically altered the incidence and clinical outcomes of bacterial meningitis. We review the shifting epidemiology of meningitis in children, including after the implementation of ...
Janowski, Andrew B, Newland, Jason G
core +3 more sources

