Results 91 to 100 of about 283,327 (339)

Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells

Advanced Science, EarlyView.
The study identifies elevated homocysteine (Hcy) levels in idiopathic pulmonary fibrosis patients' samples, with alveolar type 2 cells as the primary site of Hcy metabolism. Methionine synthase reductase downregulation in these cells exacerbates fibrosis, while folate administration reduces Hcy levels and alleviates fibrosis.
Jiefeng Huang, Ke Fang, Wuyan Lu, Rongrong Wu, Yuanyuan Chen, Linxiao Li, Zihao Hu, Zixin Cai, Yu Jiang, Xinli Fan, Jinyi Deng, Guangpeng Liu, Zhuang Luo, Lei Cui, Shuaijun Li   +14 more
wiley   +1 more source

IPGCA: A Comprehensive Single Cell Atlas of 1 074 127 Porcine Intestinal Cells Revealing Cellular Dynamics, Genetic Regulation, and Cross‐Species Conservation

Advanced Science, EarlyView.
A high resolution integrated cell atlas of the pig intestine provides insights into the genetic mechanisms of complex traits (Created in BioRender. Yu, P. (2025) https://BioRender.com/o14c563) Abstract The porcine intestinal tract is vital for nutrient absorption, immune regulation, and various physiological processes.
Pengfei Yu, Qinqin Xie, Xiaodian Cai, Zhanming Zhong, Ran Wei, He Han, Shuang Liu, Zhenyang Zhang, Lingyao Xu, Zitao Chen, Zhe Zhang, Qishan Wang, Yuchun Pan, Zhen Wang, Zhe Zhang   +14 more
wiley   +1 more source

Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity

G3: Genes, Genomes, Genetics, 2020
There has been extensive discussion of the “Replication Crisis” in many fields, including genome-wide association studies (GWAS). We explored replication in a mouse model using an advanced intercross line (AIL), which is a multigenerational intercross ...
Xinzhu Zhou, Celine L. St. Pierre, Natalia M. Gonzales, Jennifer Zou, Riyan Cheng, Apurva S. Chitre, Greta Sokoloff, Abraham A. Palmer   +7 more
doaj   +1 more source

تجزیه و تحلیل غنی سازی مجموعه های ژنی با استفاده از مطالعه گسترده پویش ژنوم برای شناسایی ژن ها و مسیرهای زیستی مرتبط با دوقلوزایی در گوسفند بلوچی [PDF]

تحقیقات تولیدات دامی, 2019
گوسفند بلوچی یکی از نژادهای بومی ایران است که از شرق کشور منشا گرفته و با شرایط آب و هوایی آن منطقه سازگار شده است. بازده اقتصادی اصلاح نژاد گوسفند به طور واضحی با بازده تولیدمثل میش­ها مرتبط است. در این پژوهش، صفت دوقلوزایی به عنوان یک صفت تولیدمثلی مهم
سید مهدی اسماعیلی فرد, سید حسن حافظیان, محسن قلی زاده, رستم عبدالهی آرپناهی   +3 more
doaj   +1 more source

From GWAS to signal validation: An approach for estimating genetic effects while preserving genomic context [PDF]

, 2023
Scott Wolf, Varada Abhyankar, Diogo Melo, Julien F. Ayroles, Luisa F. Pallares   +4 more
openalex   +1 more source

Single‐Cell RNA Sequencing of Thyroid Tissues Reveals Pathogenesis of Graves' Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing and TCR profiling, this study constructed an immune cell atlas in thyroid tissue of Graves’ disease (GD), revealing dominant IFN‐γ‐secreting CD4+ T cells, expanded Tph and CD11c+ B cells, and enriched T/NK cells. Notably, GD thyroid follicular cells (TFCs) activated γδ T cells, which recruited cDC1 cells, suggesting a ...
Xiaoyi Zhou, Jia Cong, Rongguang Peng, Dichen Yang, Chenchen Dong, Jing Xie, Jiqi Yan, Jie Kuang, Fubin Li, Leng Siew Yeap, Xiaoyan Xie, Haolong Yin, Rulai Han, Liyun Shen, Yulin Zhou, Guang Ning, Shu Wang, Weiqing Wang, Lei Ye   +18 more
wiley   +1 more source

Genome-wide association study for anther length in some elite bread wheat germplasm

Czech Journal of Genetics and Plant Breeding, 2018
The anther is a crucial organ for the development of the spike in bread wheat (Triticum aestivum L.). Long anthers contain large amounts of pollen grains; thus, they are favourable for cross-pollination and increase resilience against adverse ...
Xiaopeng SONG, Jie FENG, Zixia CUI, Chuanliang ZHANG, Daojie SUN   +4 more
doaj   +1 more source

GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer

Nature Communications, 2020
Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to 119,715 individuals and identify 74
Wei Zhou, B. Brumpton, O. Kabil, J. Gudmundsson, G. Thorleifsson, Josh Weinstock, M. Zawistowski, J. Nielsen, L. Chaker, M. Medici, A. Teumer, S. Naitza, S. Sanna, U. Schultheiss, A. Cappola, J. Karjalainen, M. Kurki, M. Oneka, P. Taylor, L. Fritsche, S. Graham, B. Wolford, William Overton, Humaira Rasheed, E. Haug, M. Gabrielsen, A. Skogholt, I. Surakka, G. Davey Smith, Anita Pandit, Tanmoy Roychowdhury, W. Hornsby, J. Jónasson, L. Senter, S. Liyanarachchi, M. Ringel, Li Xu, L. Kiemeney, Huiling He, R. Netea-Maier, J. Mayordomo, T. Plantinga, J. Hrafnkelsson, H. Hjartarson, E. Sturgis, A. Palotie, M. Daly, Cintia E. Citterio, P. Arvan, C. Brummett, M. Boehnke, A. de la Chapelle, K. Stefánsson, K. Hveem, C. Willer, B. Åsvold   +55 more
semanticscholar   +1 more source

LncRNA THUMPD3‐AS1 Regulates Behavioral and Synaptic Structural Abnormalities in Schizophrenia via miR‐485‐5p and ARHGAP8

Advanced Science, EarlyView.
Schizophrenia (SCZ) is linked to synaptic structural deficits driven by dysregulated noncoding RNAs. Using the novel ceRNAxis pipeline, THUMPD3‐AS1/miR‐485‐5p/ARHGAP8 is identified as a key regulator of actin cytoskeletal remodeling through noncanonical RhoB/C‐ROCK2 signaling. Modulating this axis ameliorates SCZ‐like phenotypes in mice and aligns with
Xiaojuan Gong, Lingxi Chen, Xin Guo, Anna Jiang, Yayi He, Chunxia Yan, Liang Ma, Jiayang Gao, Jinyu Zhang, Bao Zhang   +9 more
wiley   +1 more source

Early Detection of Candidate Genes for Body Weight in Indonesian Cattle Breeds with Genome-Wide Association Study (GWAS)

Acta Veterinaria
Genome-wide association study (GWAS) was used to detect candidate genes affecting economic traits in livestock. GWAS can detect single nucleotide polymorphisms (SNPs) in all chromosome regions.
Putra Widya Pintaka Bayu, Hartati Hartati, Mariyono Mariyono, Noor Ronny Rachman, Sumantri Cece, Margawati Endang Tri   +5 more
doaj   +1 more source