Results 111 to 120 of about 283,327 (339)

Domestication of Tartary Buckwheat Shaped a Regulatory Module for Seedling Salt Tolerance by Targeting the Magnesium Transporter Gene FtMGT2

Advanced Science, EarlyView.
Domestication of Tartary buckwheat is selected for a salt tolerance mechanism involving the magnesium transporter FtMGT2. Its expression is controlled by the FtAGL16‐FtMYB15L module, which is stabilized under salt stress through a competitive interaction that blocks its degradation by the E3 ligase FtBRG1, ultimately boosting Na⁺ efflux and plant ...
Xiang Lu, Yuqi He, Wenfeng Weng, Zebin Liu, Yuanfen Gao, Yaliang Shi, Wei Li, Dili Lai, Mengyu Zhao, Rintu Jha, Hui Zhao, Guangsheng Li, Chaonan Guan, Shuai Shao, Jingjun Ruan, Sun Hee Woo, Yinan Ouyang, Muriel Quinet, Milen I. Georgiev, Alisdair R. Fernie, Congcong Hou, Kaixuan Zhang, Xu Liu, Meiliang Zhou   +23 more
wiley   +1 more source

Dissection of acidity-related traits in an apricot (Prunus armeniaca L.) germplasm collection revealed the genetic architecture of organic acids content and profile

Fruit Research
Fruit acidity-related traits significantly influence consumer preferences for apricots (Prunus armeniaca L.). This study evaluated the variability associated with overall fruit acidity, and the content and profiles of ten organic acids (cis-aconitate ...
Irina Baccichet, Remo Chiozzotto, Debora Tura, Alessandro Giulio Tagliabue, Stefano Tartarini, Cassia da Silva Linge, Anna Spinardi, Laura Rossini, Daniele Bassi, Marco Cirilli   +9 more
doaj   +1 more source

Reaching the End-Game for GWAS: Machine Learning Approaches for the Prioritization of Complex Disease Loci

Frontiers in Genetics, 2020
Genome-wide association studies (GWAS) have revealed thousands of genetic loci that underpin the complex biology of many human traits. However, the strength of GWAS – the ability to detect genetic association by linkage disequilibrium (LD) – is also its ...
Hannah L Nicholls, C. John, David Watson, P. Munroe, Michael R. Barnes, C. Cabrera   +5 more
semanticscholar   +1 more source

Microglial Feimin Alleviates Cognitive Impairment in High‐Fat Diet‐Fed Mice

Advanced Science, EarlyView.
Microglial feimin deletion exacerbates lipotoxicity‐induced neuroinflammation and cognitive decline. In both in vitro and in vivo models, loss of feimin aggravated lipid droplet accumulation, IL‐1β/IL‐6 release, and neuronal injury through the PI3K–AKT–mTOR pathway, ultimately leading to severe neuronal apoptosis and cognitive impairment under high‐fat
Ran Gao, Zhonghua Xiong, Wenting Su, Jiahui Deng, Bin Zhai, Gaizhi Zhu, Min Zhang, Qi Zeng, Jinming Qiu, Ziqing Bian, He Xiao, Guoming Luan, Renxi Wang   +12 more
wiley   +1 more source

Selective sweep and GWAS provide insights into adaptive variation of Populus cathayana leaves

Forestry Research
Leaf morphology plays a crucial role in predicting the productivity and environmental adaptability of forest trees, making it essential to understand the genetic mechanisms behind leaf variation.
Xinglu Zhou, Xiaodong Xiang, Demei Cao, Lei Zhang, Jianjun Hu   +4 more
doaj   +1 more source

The advantages and limitations of trait analysis with GWAS: a review

Plant Methods, 2013
Over the last 10 years, high-density SNP arrays and DNA re-sequencing have illuminated the majority of the genotypic space for a number of organisms, including humans, maize, rice and Arabidopsis.
A. Korte, Ashley Farlow
semanticscholar   +1 more source

Comprehensive Measurement of Inter‐Individual Variation in DNA Repair Capacity in Healthy Individuals

Advanced Science, EarlyView.
Susceptibility to the health effects of DNA damage depends on a person's ability to repair DNA damage, but DNA repair has been difficult to measure in populations. A functional assay called FM‐HCR is used to measure DNA repair in 6 major pathways across 56 individuals.
Ting Zhai, Patrizia Mazzucato, Catherine Ricciardi, David C. Christiani, Liming Liang, Leona D. Samson, Isaac A. Chaim, Zachary D. Nagel   +7 more
wiley   +1 more source

Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk

Advanced Science, EarlyView.
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu, Bingxing An, Jumei Zheng, Qiao Wang, Zhirui Yang, Zhengda Li, Dawei Liu, Fan Ying, Jie Wen, Lingzhao Fang, Guiping Zhao   +10 more
wiley   +1 more source

Study on population structure of kiwifruit and GWAS for hairiness character

, 2022
Shimao Zheng, Yuexing Wang, Dong Qu, Wang Sun, Yuehua Yu, Yu Zhang   +5 more
openalex   +1 more source

A Forward Genetics Strategy for High‐Throughput Gene Identification via Precise Image‐Based Phenotyping of an Indexed EMS Mutant Library

Advanced Science, EarlyView.
The GeneHunter‐Gene‐Level Association (GH‐GLA) pipeline enables high‐throughput gene identification in an indexed EMS population of wheat cultivar KN9204. It identifies 5905 trait‐associated wheat genes and validates key regulators of kernel weight and spikelet architecture via gene editing and haplotype analysis.
Haojie Wang, Fujun Sun, Zeyu Shi, Yufeng Yang, Yi Ding, Tengteng Zhang, Caihong Zhao, Jingzhong Xie, Yaqian Zhang, Caihua Li, Wenqiang Tang, Junming Li, Xigang Liu, Shusong Zheng, Ni Jiang, Fei He, Shuzhi Zheng   +16 more
wiley   +1 more source