Results 141 to 150 of about 283,327 (339)
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia
Molecular Autism, 2017 BackgroundOver the past decade genome-wide association studies (GWAS) have been applied to aid in the understanding of the biology of traits. The success of this approach is governed by the underlying effect sizes carried by the true risk variants and ...Richard J. L. Stephan Verneri Jakob Peter Hailiang Lambert Anney Ripke Anttila Grove Holmans Huang Klei Lee M, R. Anney, S. Ripke, V. Anttila, J. Grove, P. Holmans, Hailiang Huang, L. Klei, Phil H. Lee, S. Medland, B. Neale, E. Robinson, L. Weiss, L. Zwaigenbaum, T. Yu, Kerstin Wittemeyer, A. Willsey, E. Wijsman, T. Werge, T. Wassink, Regina Waltes, C. Walsh, S. Wallace, J. Vorstman, V. Vieland, A. Vicente, H. vanEngeland, Kathryn M. Tsang, A. Thompson, P. Szatmari, Oscar Svantesson, S. Steinberg, K. Stefánsson, H. Stefánsson, M. State, L. Soorya, T. Silagadze, S. Scherer, G. Schellenberg, S. Sandin, Stephan J Sanders, E. Saemundsen, G. Rouleau, B. Rogé, K. Roeder, W. Roberts, J. Reichert, A. Reichenberg, K. Rehnström, R. Regan, F. Poustka, Christopher S. Poultney, J. Piven, D. Pinto, M. Pericak-Vance, M. Pejović-Milovančević, M. Pedersen, C. Pedersen, A. Paterson, J. Parr, A. Pagnamenta, G. Oliveira, J. Nurnberger, M. Nordentoft, M. Murtha, S. Mouga, P. Mortensen, O. Mors, E. Morrow, D. Moreno-De-Luca, A. Monaco, N. Minshew, Alison K. Merikangas, W. McMahon, S. McGrew, M. Mattheisen, I. Martsenkovsky, Donna M. Martin, S. Mane, P. Magnússon, T. Magalhães, E. Maestrini, J. Lowe, C. Lord, P. Levitt, C. Martin, D. Ledbetter, M. Leboyer, A. Lecouteur, C. Ladd-Acosta, A. Kolevzon, S. Klauck, Suma Jacob, Bozenna Iliadou, C. Hultman, D. Hougaard, I. Hertz-Picciotto, R. Hendren, C. Hansen, J. Haines, Stephen J. Guter, D. Grice, Jonathan Green, A. Green, A. P. Goldberg, C. Gillberg, J. Gilbert, L. Gallagher, C. Freitag, E. Fombonne, S. Folstein, B. Fernandez, M. Fallin, A. Ercan-Sencicek, S. Ennis, F. Duque, E. Duketis, R. Delorme, S. DeRubeis, M. DeJonge, G. Dawson, M. Cuccaro, C. Correia, J. Conroy, Inȇs C. Conceição, A. Chiocchetti, Patrícia B. S. Celestino-Soper, J. Casey, R. Cantor, C. Café, J. Bybjerg-Grauholm, Sean Brennan, T. Bourgeron, P. Bolton, S. Bölte, N. Bolshakova, C. Betancur, R. Bernier, A. Beaudet, A. Battaglia, V. Bal, G. Baird, A. Bailey, Marie Bækvad-Hansen, J. Bader, E. Bacchelli, E. Anagnostou, David G. Amaral, J. Almeida, A. Børglum, J. Buxbaum, A. Chakravarti, E. Cook, H. Coon, D. Geschwind, M. Gill, Joachim Hallmayer, A. Palotie, S. Santangelo, J. Sutcliffe, D. Arking, B. Devlin, M. Daly +162 moresemanticscholar +1 more sourceTreg Cells Modulate Neuroinflammation and Behavioral Deficits in Autism: Evidence From MR‐Based Genetic Analyses and Experimental Models
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT
Autism spectrum disorder (ASD) is a neurodevelopmental condition that is increasingly linked to immune dysfunction and neuroinflammation. Regulatory T cells (Tregs), which are crucial in maintaining immune homeostasis, have been implicated in the pathogenesis of ASD.Zuqing Nie, Xinyi Xu, Junhao Chen, Huiling Chen, Meng Li, Yang Zhang, Zhiwei Li, Chen Shen, Jie Wen, Xia Cao +9 morewiley +1 more sourceMolecular Profiling of Genes Associated With Methylphenidate Pathway Therapy and Discovery of New Variants in Amazonian Amerindian Populations
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT
In Attention Deficit Hyperactivity Disorder (ADHD), methylphenidate is one of the most widely used drugs, in which patient response significantly impacts prognosis. This study aimed to characterize the molecular profile of 10 genes associated with methylphenidate therapy.Aline Pasquini Santos, Tatiane Carinta de Souza, Kaio Evandro Cardoso Aguiar, Ana Caroline Alves da Costa, Natasha Monte, Juliana Carla Gomes Rodrigues, Giovanna Gilioli da Costa Nunes, Rita de Cássia Calderaro Coelho, Ândrea Ribeiro‐dos‐Santos, André Maurício Ribeiro dos Santos, Sandro José de Souza, Sidney Emanuel Batista dos Santos, Rommel Mario Rodriguez Burbano, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos +14 morewiley +1 more sourceSchizophrenia Genetics Modulates Clinical Depressive Features
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT
Schizophrenia (SCZ) genetic liability, quantified by polygenic scores (PGS), may influence clinical phenotypes in major depressive disorder (MDD). We investigated the effect of the SCZ‐PGS derived from the latest SCZ genome‐wide association study (GWAS) on MDD symptom severity, comorbidities, and treatment outcomes.Alessandro Serretti, Daniel Souery, Siegfried Kasper, Joseph Zohar, Stuart Montgomery, Panagiotis Ferentinos, Dan Rujescu, Raffaele Ferri, Giuseppe Fanelli, Chiara Fabbri, Raffaella Zanardi, Francesco Benedetti, Bernhard T. Baune, Julien Mendlewicz +13 morewiley +1 more sourceAssociation studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. [PDF]
, 2019 Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery efforts6-11.23andMe Research Team, Bjornsdottir, Gyda, Boardman, Jason D, Boehnke, Michael, Boomsma, Dorret I, Brazel, David M, Chen, Chu, Chen, Fang, Choquet, Hélène, Cucca, Francesco, Datta, Gargi, Davies, Gareth E, Davila-Velderrain, Jose, Docherty, Anna R, Eaton, Charles B, Ehringer, Marissa A, Esko, Tõnu, Faul, Jessica D, Fiorillo, Edoardo, Foerster, Johanna R, Fritsche, Lars G, Gabrielsen, Maiken Elvestad, Gillespie, Nathan A, Gordon, Scott D, Gudbjartsson, Daniel F, Haessler, Jeffrey, Haller, Toomas, Harris, Kathleen Mullan, Heath, Andrew C, Hewitt, John K, Hickie, Ian B, Hokanson, John E, Hopfer, Christian J, Hottenga, Jouke-Jan, Huang, Hongyan, HUNT All-In Psychiatry, Hunter, David J, Iacono, William G, Jang, Seon-Kyeong, Jansen, Philip R, Jiang, Yu, Johnson, Eric O, Kamatani, Yoichiro, Kardia, Sharon LR, Keller, Matthew C, Kellis, Manolis, Kooperberg, Charles, Kraft, Peter, Krauter, Kenneth S, Laakso, Markku, Li, Yue, Lind, Penelope A, Ling, Yueh, Liu, Mengzhen, Loukola, Anu, Lutz, Sharon M, Madden, Pamela AF, Martin, Nicholas G, Matoba, Nana, McGue, Matt, McGuire, Daniel, McMahon, George, McQueen, Matthew B, Medland, Sarah E, Metspalu, Andres, Mohlke, Karen L, Mulas, Antonella, Mägi, Reedik, Nielsen, Jonas B, Okada, Yukinori, Orrù, Valeria, Palviainen, Teemu, Pandit, Anita, Peters, Ulrike, Polderman, Tinca JC, Posthuma, Danielle, Reginsson, Gunnar W, Reiner, Alexander P, Rice, John P, Rimm, Eric, Rose, Richard J, Runarsdottir, Valgerdur, Skogholt, Anne Heidi, Smith, Jennifer A, Stallings, Michael C, Stančáková, Alena, Stefansson, Hreinn, Taylor, Amy E, Thai, Khanh K, Tian, Chao, Tindle, Hilary A, Turman, Constance, Wedow, Robbee, Willemsen, Gonneke, Young, Hannah, Young, Kendra A, Zajac, Gregory JM, Zhan, Xiaowei, Zhao, Wei, Zhou, Wei +99 morecore Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA‐DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset
Annals of Neurology, EarlyView.Objectives
Multiple sclerosis (MS) onset risk factors include Epstein–Barr virus (EBV) indices (including host response), lower serum 25‐vitamin D (25(OH)D) levels, low sun exposure, and HLA‐DRB1*1501. The underlying molecular mechanisms are unclear. Here, we examined mediation through differential DNA methylation (DNAm) to better understand possible ...Steve Simpson‐Yap, Ellen Morwitch, Samuel A. Tanner, Sarah M. Thomson, Alex Eisner, Rod A. Lea, Trevor J. Kilpatrick, Jeannette Lechner‐Scott, Rodney J. Scott, Alexandre Xavier, Vicki E. Maltby, Robyn M. Lucas, Bruce V. Taylor, Brett A. Lidbury, Simon A. Broadley, Ingrid van der Mei, Mehari Woldemariam Merid, Boris Novakovic, Richard Saffery, Anna Karin Hedström, Pernilla Stridh, Tomas Olsson, Maja Jagodic, Lars Alfredsson, Anne‐Louise Ponsonby, for the Ausimmune Investigator Group, Caron Chapman, Alan Coulthard, Keith Dear, Terry Dwyer, Trevor Kilpatrick, Robyn Lucas, Tony McMichael, Anne‐Louise Ponsonby, Bruce Taylor, Patricia Valery, Ingrid van der Mei, David Williams +37 morewiley +1 more sourceAssociation between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease
Annals of Neurology, EarlyView.Objective
Lewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α‐synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte ...Marios Gavrielatos, Michael G. Heckman, Alexandra I. Soto‐Beasley, Sophia G. Blumenfeld, Xu Hou, Shunsuke Koga, Melissa E. Murray, Koji Kasanuki, Daisuke Ono, Fabienne C. Fiesel, Ryan J. Uitti, Julie A. Fields, Hugo Botha, Vijay K. Ramanan, Kejal Kantarci, Val J. Lowe, Clifford R. Jack, Nilufer Ertekin‐Taner, J. Raphael Gibbs, Bryan J. Traynor, Clifton L. Dalgard, Rodolfo Savica, Jonathan Graff‐Radford, Ronald C. Petersen, R. Ross Reichard, Neill R. Graff‐Radford, Tanis J. Ferman, Bradley F. Boeve, Zbigniew K. Wszolek, Wolfdieter Springer, Ziv Gan‐Or, Emmanuel Mignot, Sonja W. Scholz, Dennis W. Dickson, Owen A. Ross +34 morewiley +1 more sourceAmyotrophic Lateral Sclerosis and Frontotemporal Dementia Have Distinct Prediagnostic Blood Biochemical Profiles
Annals of Neurology, EarlyView.Objective
Identifying modifiable factors influencing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) risk is important for prevention. Blood biomarkers, particularly cholesterol, have been associated with neurodegenerative risk, but findings in ALS are inconsistent, and data on FTD are limited.Christos V. Chalitsios, Jiali Gao, Carol A.C. Coupland, Julia Hippisley Cox, Martin R. Turner, Alexander G. Thompson +5 morewiley +1 more source
