Results 191 to 200 of about 283,327 (339)

Human Lysozyme Transgenic Maize Improves Colonic Inflammation by Inhibiting the cGAS/STING Signaling Pathway in DSS‐Induced Colitis Mice

Food Frontiers, EarlyView.
Human lysozyme (HLZ) possesses the function of ameliorating intestinal inflammation. HLZ transgenic maize restored intestinal barrier function in colitis mice. HLZ‐feed inhibited the cGAS/STING signaling pathway by ameliorating DSS‐induced mitochondrial dysfunction.
Yinuo Yu, Yaqin Li, Xuan Chen, Rentao Song, Zhenyi Qiao, Weiwei Qi   +5 more
wiley   +1 more source

Navigating Mendelian Randomization in Sleep Medicine: Challenges, Opportunities, and Best Practices

Nature and Science of Sleep
Ahmed S BaHammam,1,2 Haitham Jahrami3,4 1The University Sleep Disorders Center, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia ...
BaHammam AS, Jahrami H
doaj  

Integration of ssGWAS and ROH analyses for uncovering genetic variants associated with reproduction traits in Large White pigs [PDF]

Zhenyang Zhang, Wei Zhao, Zhen Wang, Yuchun Pan, Qishan Wang, Zhe Zhang   +5 more
openalex   +1 more source

Direct and INdirect effects analysis of Genetic lOci (DINGO): A software package to increase the power of locus discovery in GWAS meta-analyses of perinatal phenotypes and traits influenced by indirect genetic effects [PDF]

, 2023
Liang‐Dar Hwang, Gabriel Cuéllar-Partida, Loïc Yengo, Jian Zeng, Robin N. Beaumont, Rachel M. Freathy, Gunn-Helen Moen, Nicole M. Warrington, David M. Evans   +8 more
openalex   +1 more source

Five years of GWAS discovery.

American Journal of Human Genetics, 2012
P. Visscher, M. Brown, M. McCarthy, Jian Yang   +3 more
semanticscholar   +1 more source

Marine n‐3 Polyunsaturated Fatty Acids Mitigate Obesity Traits Through PRDM16‐Driven Gene–Nutrient Interaction and Spatiotemporal Scale Browning Process

Food Frontiers, EarlyView.
This large cohort study of 45,664 participants from the UK Biobank provides strong epidemiological evidence that fish oil use was associated with 12% and 7% lower risks of obesity and high body fat percentage, respectively. Mechanistically, marine n‐3 polyunsaturated fatty acids mitigate obesity traits through PRDM16‐driven gene–nutrient interactions ...
Xiaohui Liu, Haoyu Li, Youyou Zheng, Xiaoqian Chen, Xuzhi Wan, Pan Zhuang, Wei Jia, Jianxin Yao, Haoyin Liu, Hongbo Shi, Xunan Lin, Yu Zhang, Jingjing Jiao   +12 more
wiley   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Source Data for GWAS in Supplementary Fig. 2d.mht

, 2019
Xinglong Wang
openalex   +1 more source

Understanding the Complexity of Cold Tolerance in White Clover using Temperature Gradient Locations and a GWAS Approach [PDF]

, 2018
Luis Inostroza, Mehul Bhakta, Hernán Acuña, Catalina Vásquez, J. Martin Ibanez, Gerardo Tapia, Wenbin Mei, Matias Kirst, Márcio F. R. Resende, Patricio Muñoz   +9 more
openalex   +1 more source

Identification of Cathepsin H and Metabolic Traits as Potential Biomarkers for Lung Cancer by Mendelian Randomization and Single‐Cell Transcriptomics

Advanced Genetics, EarlyView.
This study explores the link between CTSH and lung cancer, covering global trends in lung cancer and hyperglycemia, MR analysis of CTSH and 233 metabolic traits, and scRNA analysis, along with multi‐level validation of CTSH expression in LUAD. These findings offer valuable insights into lung cancer biology and provide new perspectives for biomarker ...
Chenghu Song, Weici Liu, Zhao He, Jiwei Liu, Ruixin Wang, Lei Wu, Yize Wang, Mingfeng Zheng, Dong Tian, Wenjun Mao   +9 more
wiley   +1 more source