Results 231 to 240 of about 244,292 (300)
Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT
The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara +5 morewiley +1 more sourcePolygenic Risk for Pre‐Eclampsia and the Long‐Term Risk of Incident Hypertension and Cardiovascular Disease: A Population‐Based Cohort Study
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Objective
To investigate whether genetic predisposition to pre‐eclampsia (PE), measured by a polygenic risk score (PRS), is associated with incident hypertension and cardiovascular disease (CVD) after delivery in Asian women. Design
Prospective population‐based cohort study.Eun‐Saem Choi, Sang‐Hyuk Jung, Young Mi Jung, Chan‐Wook Park, Joong Shin Park, Jong Kwan Jun, Jaeyoung Kim, Beomsu Kim, Chamlee Cho, Injeong Shim, Dokyoon Kim, Hong‐Hee Won, Seung Mi Lee +12 morewiley +1 more sourceExploring the genetic overlap between substance use disorder and educational attainment
Addiction, EarlyView.Abstract Background and aims
Substance use disorder (SUD) is a polygenic psychiatric condition characterized by persistent drug use despite negative consequences. Several studies support that higher cognitive performance and educational attainment (EA) are associated with a reduced risk for SUD.Judit Cabana‐Domínguez, Laura Vilar‐Ribó, María Soler Artigas, Silvia Alemany, Natalia Llonga, Pau Carabí‐Gassol, Uxue Zubizarreta‐Arruti, Valeria Macias‐Chimborazo, Lara Grau‐López, Constanza Daigre, Elena Ros‐Cucurull, Raúl Felipe Palma‐Alvarez, Germán Ortega‐Hernández, Noèlia Fernàndez‐Castillo, Bru Cormand, Josep Antoni Ramos‐Quiroga, Marta Ribasés +16 morewiley +1 more sourceTrajectories of genetic risk across dimensions of alcohol use behaviors
Addiction, EarlyView.Abstract Background and aims
Alcohol use behaviors (AUBs) manifest in a variety of normative and problematic ways across the life course, all of which are heritable. Twin studies show that genetic influences on AUBs change across development, but this is usually not considered in research identifying and investigating the genes linked to AUBs ...Jeanne E. Savage, Fazil Aliev, Peter B. Barr, Maia Choi, Gabin Drouard, Megan E. Cooke, Sally I. Kuo, Mallory Stephenson, Sarah J. Brislin, Zoe E. Neale, Spit for Science Working Group, Karen Chartier, Ananda Amstadter, Danielle M. Dick, Emily Lilley, Renolda Gelzinis, Anne Morris, Katie Bountress, Amy E. Adkins, Nathaniel Thomas, Zoe Neale, Kimberly Pedersen, Thomas Bannard, Seung B. Cho, Peter Barr, Holly Byers, Erin C. Berenz, Erin Caraway, James S. Clifford, Megan Cooke, Elizabeth Do, Alexis C. Edwards, Neeru Goyal, Laura M. Hack, Lisa J. Halberstadt, Sage Hawn, Sally Kuo, Emily Lasko, Jennifer Lend, Mackenzie Lind, Elizabeth Long, Alexandra Martelli, Jacquelyn L. Meyers, Kerry Mitchell, Ashlee Moore, Arden Moscati, Aashir Nasim, Jill Opalesky, Cassie Overstreet, A. Christian Pais, Tarah Raldiris, Jessica Salvatore, Jeanne Savage, Rebecca Smith, David Sosnowski, Jinni Su, Chloe Walker, Marcie Walsh, Teresa Willoughby, Madison Woodroof, Jia Yan, Cuie Sun, Brandon Wormley, Brien Riley, Fazil Aliev, Roseann Peterson, Bradley T. Webb, COGA Investigators, Bernice Porjesz, Victor Hesselbrock, Arpana Agrawal, Danielle Dick, Howard J. Edenberg, Tatiana Foroud, Yunlong Liu, Martin H. Plawecki, Samuel Kuperman, Allan Anderson, Jacquelyn Meyers, Laura Bierut, Sarah Hartz, Marc Schuckit, Ronald Hart, Jay Tischfield, Laura Almasy, Alison Goate, Paul Slesinger, Denise Scott, Cathryn Holzhauer, Michie Hesselbrock, Dongbing Lai, John Nurnberger Jr., Leah Wetherill, Xiaoling Xuei, Sean O'Connor, John Kramer, Grace Chan, Chella Kamarajan, Ashwini Pandey, David B. Chorlian, Sivan Kinreich, Gayathri Pandey, Chris Chatzinakos, Jian Zhang, Stacey Saenz deViteri, Christian Richard, Arjun Bingly, Gita Pathak, Andrey Anokhin, Kathleen Bucholz, Fanghong Dong, Alexander Hatoum, Emma Johnson, Vivia McCutcheon, John Rice, Scott Saccone, Zhiping Pang, Sarah Brislin, Jennifer Moore, Alison Merikangas, Miri Gitik, Antti Latvala, Richard J. Rose, Jaakko Kaprio, Danielle M. Dick, Jacquelyn Meyers, Jessica E. Salvatore, Danielle Posthuma +127 morewiley +1 more sourceTrans-ancestry GWAS of hot flashes reveals potent treatment target and overlap with psychiatric disorders. [PDF]
Commun Med (Lond)Werwath KE, Lawn RB, Salem MT, Li T, Mitchell BL, Shen H, Gordon SD, Kung B, Stafford C, Vemuri M, Ratanatharathorn A, Meijsen J, Shadyab AH, Kooperberg C, Koenen KC, Crandall CJ, Martin NG, Duncan LE. +17 moreeuropepmc +1 more sourceCausal relationship between immune cells and idiopathic thrombocytopenic purpura: A bidirectional Mendelian randomization study
Rheumatology &Autoimmunity, EarlyView.Heyi Zhang, Luyao Song, Ying Mao, Zerui Liu, Zhexi He, Mengxia Liu, Jingfang Zhang, Rui Zhao, Jing Luo, Shengxiao Zhang +9 morewiley +1 more source
