Results 221 to 230 of about 198,268 (313)

A genome-wide association study of cognitive impairment in a Chinese cohort of 1,040 individuals. [PDF]

Hum Genet
Wang MH, Zhang Y, Sun R, Li F, Zhang T, Gu X, Lou J, Cao L, Su S, Zheng H, Liu C, Chong MKC, Wu WKK, Yu J, Zee BC, Lin J.   +15 more
europepmc   +1 more source

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source

Experimental benchmarking of in silico annotations at prostate cancer risk loci and hypothesis-generating cross-cancer prioritisation of ovarian risk variants. [PDF]

Genomics Inform
Al-Amili WA, Ayyed Najm M, Jumaah SS, Suleiman AA.   +3 more
europepmc   +1 more source

Obstructive Sleep Apnea and BMI, Body Fat Percentage in the East Asian Population: A Bidirectional and Multivariate Mendelian Randomization Study

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective To explore the causal relationship between obstructive sleep apnea and body fat percentage and body mass index (BMI) in the East Asian population by using bidirectional Mendelian randomization and multivariate Mendelian randomization.
Rui Fan, Wen‐Jun Lu, Hua Zhang, Hai‐Ling Jiang, Tao Li, Yan Yan   +5 more
wiley   +1 more source

Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus. [PDF]

BMC Genomics
Zhang Y, Moore A, Ryckman KK, Yan Q, Guerrero RF, Li M, Silver RM, Luo J, Yee LM, Reddy UM, Feghali MN, Chung J, Haas DM, Kua KL, Liu N.   +14 more
europepmc   +1 more source

The Relationship Between Blood Lipids, Coagulation Indexes, Blood Homocysteine and Sudden Deafness: A Retrospective Study and Mendelian Randomization Analysis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Certain blood components, including blood lipids, coagulation parameters, and homocysteine, have been suggested to correlate with the incidence and prognosis of sudden sensorineural hearing loss (SSNHL). However, the nature of these associations remains controversial.
Feng‐Xin Yang, Yu‐Wan Song, Yan Wang, Kun Zhao, Hu‐Hui‐Fen He, Jing‐Jing Qiu, Da‐Wei Liu, Bo Li, Yan Sun   +8 more
wiley   +1 more source

A joint genome-wide association study reveals candidate genes associated with egg production traits in chickens. [PDF]

Poult Sci
Fu M, Pi J, Chen Y, Pan A, Zhang H, Huang T, Wu Y.   +6 more
europepmc   +1 more source

Effects of Obstructive Sleep Apnea on Personality and Temperament: A Cohort and Mendelian Randomization Study

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Obstructive sleep apnea (OSA) is associated with neurocognitive impairment, but its causal relationship with personality traits remains poorly understood. This study investigates the association and causality between OSA and personality using both cohort and genetic data.
Jian‐Hong Liao, Yun‐Han Shi, Xin‐Peng Xu, Yan‐Ru Li, De‐Min Han   +4 more
wiley   +1 more source

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Expanding the pig metabolomics QTL catalog. [PDF]

Genet Sel Evol
Ibragimov E, Morsing MK, Rydal MP, Cai Z, Stenlund H, Nielsen JP, Fredholm M, Karlskov-Mortensen P.   +7 more
europepmc   +1 more source