Results 221 to 230 of about 191,618 (313)

SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy

Movement Disorders, EarlyView.
Abstract Hereditary spastic paraplegias (HSPs) comprise a heterogeneous group of heritable neurodegenerative disorders resulting from mutations in a wide variety of genes. HSP locomotor symptoms include lower limb weakness and spasticity that arise from progressive degeneration of corticospinal axons projecting from the motor cortex to the distal ...
Emanuela Piermarini, Peter W. Baas
wiley   +1 more source

Beyond BMI: Genome‐Wide Associations of Visceral Fat, Fat Mass, and Fat‐Free Mass in Eastern Asian Populations

Obesity, EarlyView.
ABSTRACT Objective BMI is widely used to define obesity and may not capture heterogeneity in body fat distribution. Genetic studies of obesity have largely focused on BMI but not visceral fat and fat‐free mass, which is particularly limited in East Asian populations.
Hsin‐Ming Lu, Shun‐Jen Chang, Kuei‐Hau Luo, Yun‐Shiuan Chuang, Fu‐Wen Liang, Hung‐Yi Chuang   +5 more
wiley   +1 more source

Genome-wide association study of sarcopenia index reveals sex-stratified genetic architecture. [PDF]

Biol Sex Differ
Mu Y, Liao B, Luo M, Lu K, Tang H, Nie M, Sun X.   +6 more
europepmc   +1 more source

Past, present and future of local crop evolution

PLANTS, PEOPLE, PLANET, EarlyView.
Promoting agrobiodiversity is a promising strategy for mitigating the negative effects of climate change on global food security. We highlight the central role evolutionary processes play in harnessing the potential of local crops by integrating genomics, archaeology, ethnobotany and traditional ecological knowledge (TEK).
Nataly Allasi Canales, Philippa Ryan, Amy Jackson, Hong Phuong Le, James Borrell, Aaron Davis, Rafal M. Gutaker   +6 more
wiley   +1 more source

Protein mediators of chronic kidney disease in Type 2 diabetes: A mendelian randomization study. [PDF]

PLoS Med
Liang KYH, Zheng TM, Tan D, Sasako T, Ilboudo Y, Chen Y, Butler-Laporte G, Yoshiji S, Richards JB.   +8 more
europepmc   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

Robust inference and correlates from genetic associations with personality. [PDF]

Nature
Schwaba T, Clapp Sullivan ML, Akingbuwa WA, Ilves K, Tanksley PT, Williams CM, Dragostinov Y, Mallard TT, Tubbs JD, Liao W, Ackerman LS, Fealy JCM, Hemani G, de la Fuente J, Smith GD, Gupta P, Stein MB, Gelernter J, Levey DF, Võsa U, Ausmees L, Realo A, Estonian Biobank Research Team, Vaht M, Allik J, Esko T, Mõttus R, Vainik U, Jonsdottir GA, Thorleifsson G, Gunnarsson ÁF, Bjornsdottir G, Thorgeirsson TE, Stefansson H, Stefansson K, Cheesman R, Qin Q, Corfield EC, Ask H, Torvik FA, Ystrom E, Tesli M, Boomsma DI, de Geus EJC, Hottenga JJ, Melo DC, Snieder H, Hartman CA, Xia C, Campbell A, Luciano M, Deary IJ, Hill WD, Jang SK, Vrieze SI, Abecasis G, Lupton MK, Mitchell BL, Viher PV, Colodro-Conde L, Martin NG, Medland SE, Derks EM, Wormington B, Kaprio J, Silventoinen K, Palviainen T, Musial A, Rimfeld K, Plomin R, Malanchini M, Dick DM, Aliev F, COGA Collaborators, Spit for Science Working Group, Wesseldijk LW, Ullén F, Mosing MA, Kranzler HR, Nunez Y, Beck S, Polimanti R, Edwards T, Giannelis A, Willoughby EA, Lee JJ, McGue M, Terracciano A, Marongiu M, Fiorillo E, Cucca F, Sutin AR, van der Most PJ, Oldehinkel AJ, Kretschmer T, Shabalin AA, Docherty AR, Krueger RF, Freilich CD, Mishra BH, Lehtimäki T, Raitakari OT, Kähönen M, Saarinen A, Dobewall H, Keltikangas-Järvinen L, Berger K, Herrera-Rivero M, Streit F, Awasthi S, Witt SH, Tuhkanen J, Räikkönen K, Eriksson JG, Lahti J, Davies G, Redmond P, Taylor A, Corley J, Russ TC, Ciullo M, Nutile T, Ding J, Qian Y, Tanaka T, Ferrucci L, Zillich L, Sirignano L, Harden KP, Genç E, Gajewski PD, Getzmann S, Fraenz C, Schneider Peñate JE, Lis S, Hall ASM, Schmahl C, Herpertz SC, Abdellaoui A, Nivard MG, Tucker-Drob EM.   +140 more
europepmc   +1 more source

From wild to tamed: Reimagining novel crops through omics and local plant diversity

PLANTS, PEOPLE, PLANET, EarlyView.
The global food system faces growing pressure from climate change, biodiversity loss, and rising nutritional demands. Agriculture has increased yields but reduced crop diversity, flavor, and nutritional quality, leaving societies vulnerable and dependent on a narrow set of staple species.
Alexandra Sanfeliu Meliá, Pablo D. Cárdenas   +1 more
wiley   +1 more source

The impact for causal associations between common diseases and inflammatory bowel disease: a disease-wide bidirectional Mendelian randomization study. [PDF]

Inflamm Res
Sun Y, Liang Z, Ou Z, Gao L, Wang YF, Yuan J, Yu G, Sun R.   +7 more
europepmc   +1 more source

Exploring eco‐evolutionary and temporal patterns of arbuscular mycorrhizal fungal communities colonizing Sorghum bicolor across sites of contrasting land use history and climate

PLANTS, PEOPLE, PLANET, EarlyView.
Sorghum bicolor is a globally important cereal crop with annual yields exceeding 50 million tons across more than 100 countries and can be grown on marginal lands where conventional agriculture is limited. We examined how eight genetically diverse sorghum genotypes shaped arbuscular mycorrhizal fungal (AMF) community assembly across two contrasting ...
Philip Brailey‐Crane, Sedona M. Spann, Thomas H. Pendergast IV, Ben J. Long, Ashton K. Brinkley, Sarah R. Mondibrown, Nancy C. Johnson, Katrien M. Devos, Jeffrey L. Bennetzen   +8 more
wiley   +1 more source