Results 241 to 250 of about 244,292 (300)

Mediation of Polygenic Asthma Risk Through Gene Expression

Allergy, EarlyView.
We apply published PRSs in African‐ancestry individuals and quantify the extent to which the PRS‐asthma relationship is mediated by clinical biomarkers and gene‐expression signatures of asthma. We found the best PRS to be the one derived using the largest sample size and including African‐ancestry individuals.
Rakesh Natarajan, Brooke Szczesny, Kanika Kanchan, Erika Esquinca, Meher Preethi Boorgula, Sameer Chavan, Monica Campbell, Wendy Lorizio, Ayo P. Doumatey, Alvaro A. Cruz, Harold Watson, Edward T. Naureckas, B. Louise Giles, Ganiyu Arinola, Olumide Sogaolu, Adegoke G. Falade, Nadia N. Hansel, Christopher O. Olopade, Charles N. Rotimi, R. Clive Landis, Camila A. Figueiredo, Eimear E. Kenny, Ingo Ruczinski, Andrew H. Liu, Carole Ober, Margaret A. Taub, Randi K. Johnson, Kathleen C. Barnes, Genevieve L. Wojcik, Rasika A. Mathias   +29 more
wiley   +1 more source

Integrative analysis of GWAS, Bayesian fine-mapping, Mendelian randomization and colocalization reveals genetic determinants underlying milk-related traits in dairy cattle. [PDF]

Genet Sel Evol
Teng J, Zhao X, Yan Q, Yang J, Pei F, Zhang X, Duan C, Chen Z, Xu Q, Liu Y, Xue G, Xia S, Wang H, Gu Y, Fang L, Liu H, Gao H, An J, Jiang L, Ning C, Li R, Gao Y, Wang X, Li J, Zhang Q.   +24 more
europepmc   +1 more source

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits [PDF]

, 2017
Barata, Llilda, Borecki, Ingrid B, Czajkowski, Jacek, et al,, Feitosa, Mary F, Heath, Andrew C, Madden, Pamela A.F., Rao, D.C., Rice, Treva, Sung, Yun Ju   +9 more
core   +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

Multitrait analyses identify genetic variants associated with aortic valve function and aortic stenosis risk. [PDF]

Nat Genet
Kany S, Rämö JT, Hou C, Jurgens SJ, Khurshid S, Nauffal V, Cunningham JW, Lau ES, Koyama S, FinnGen, Ho JE, Olgin JE, Elmariah S, Palotie A, Lindsay ME, Ellinor PT, Pirruccello JP.   +16 more
europepmc   +1 more source

Genetics of infertility and “assisted fertilization” in the Bible: The case of Abraham and his family

Andrology, EarlyView.
Abstract Couple infertility is a very ancient medical condition. One of the first descriptions of familial infertility/subfertility is contained in the first book of the Bible, Genesis, written in the 10th century BC and reporting tales from the oral tradition even occurred about 800 years earlier.
Manuela Simoni, Frank Tüttelmann, Livio Casarini   +2 more
wiley   +1 more source

Mitochondria-Related Gene BDH1 Implicated in Myopia Risk via Methylation-Regulated Expression: An Integrative Summary-Data Mendelian Randomization Study. [PDF]

Transl Vis Sci Technol
Peng S, Deng H, Tao Z, Chen J, Kang Z.
europepmc   +1 more source

The Testicular Cancer Consortium (TECAC): Filling Knowledge Gaps in the Genetic Etiology of Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Background The Testicular Cancer Consortium (TECAC) was established in 2012 and is comprised of researchers from over 25 centers in Europe and North America. TECAC's overarching goal is to investigate the genetic susceptibility of testicular germ cell tumors (TGCT) to better understand their biology, impact prevention strategies, and inform ...
Peter A. Kanetsky, Kristian Almstrup, Svetlana Cherlin, Victoria K. Cortessis, Alberto Ferlin, Jourik A. Gietema, Anna González‐Neira, Tom Grotmol, Robert J. Hamilton, Trine B. Haugen, Lambertus A. Kiemeney, Jung Kim, Csilla Krausz, Davor Lessel, Ragnhild A. Lothe, Kevin T. Nead, Jérémie Nsengimana, Jenny N. Poynter, Ewa Rajpert‐DeMeyts, Lorenzo Richiardi, Stephen M. Schwartz, Rolf I. Skotheim, Douglas R. Stewart, Clare Turnbull, Fredrik Wiklund, Tongzhang Zheng, Katherine L. Nathanson, Katherine A. McGlynn, for the Testicular Cancer Consortium   +28 more
wiley   +1 more source

Causal associations between autoimmune diseases and cognitive impairment: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Jin X, Wang J, Du YJ, Wang YY, Lu ZW, Li BZ.   +5 more
europepmc   +1 more source