Results 81 to 90 of about 4,184,724 (185)

Structural compression and entorhinal vulnerability: Linking tentorial adjacency to tau burden and dementia progression

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Early neurofibrillary tau degeneration in the entorhinal cortex (EC) is a hallmark of Alzheimer's disease (AD) and aging. We propose a biomechanical cascade hypothesis, suggesting proximity to the tentorial incisura (TI) may render the EC susceptible to chronic mechanical stress, potentially contributing to tau pathology.
Luyue Zhang, Ana M. Franceschi, John F. Crary, Frank A. Provenzano, for the Alzheimer's Disease Neuroimaging Initiative   +4 more
wiley   +1 more source

Orbitofrontal and Medial Frontal Gray Matter Volumes Are Associated With Hyperactivity Traits in 2548 Nonclinical Adults

Human Brain Mapping, Volume 47, Issue 14, October 1, 2026.
In 2548 nonclinical adults, smaller orbitofrontal and medial frontal cortex gray matter volumes were associated with higher hyperactivity traits (r = −0.07 to −0.08). These small, robust effects, consistent with ENIGMA ADHD findings, suggest frontal structure–trait mapping extends to the nonclinical ADHD continuum.
Handityo Aulia Putra, Kaechang Park
wiley   +1 more source

A Complex Interplay of Vitamin B1 and B6 Metabolism with Cognition, Brain Structure, and Functional Connectivity in Older Adults

Frontiers in Neuroscience, 2017
Aging is associated with brain atrophy, functional brain network reorganization and decline of cognitive performance, albeit characterized by high interindividual variability.
Kai Jannusch, Kai Jannusch, Christiane Jockwitz, Christiane Jockwitz, Christiane Jockwitz, Hans-Jürgen Bidmon, Susanne Moebus, Katrin Amunts, Katrin Amunts, Katrin Amunts, Svenja Caspers, Svenja Caspers, Svenja Caspers   +12 more
doaj   +1 more source

MRI Characterization of Structural Brain Abnormalities in NGLY1 Deficiency

International Journal of Developmental Neuroscience, Volume 86, Issue 6, October 2026.
Structural MRI from 11 patients with NGLY1 deficiency, an ultrarare neurodevelopmental disorder, revealed reduced subcortical volume (thalamus and putamen) across ages and reduced cortical surface area in younger patients. These measures tracked with clinical features such as seizures and gait disturbance, supporting brain imaging as a candidate ...
Emily L. Dennis, Lei Zhu, William F. Mueller, Jennifer W. Cook, Gracie Morrison, Matt Wilsey, Ryan Dant, Selina Dwight, Kevin J. Lee   +8 more
wiley   +1 more source

Individualized cortical gyrification in neonates with congenital heart disease [PDF]

Congenital heart disease is associated with impaired early brain development and adverse neurodevelopmental outcomes. This study investigated how individualized measures of preoperative cortical gyrification index differ in 142 infants with congenital ...
Nosarti, Chiara, Counsell, Serena; id_orcid, Rutherford, Mary, O'Muircheartaigh, Jonathan; id_orcid, Kumar, Manu, Chew, Andrew, Bonthrone, Alexandra, Cawley, Paul, Pushparajah, Kuberan; id_orcid, Tournier, Jacques-Donald, Edwards, David; id_orcid, Hajnal, Jo; id_orcid, Wilson, Sian, Simpson, John, Kelly, Christopher, Dimitrova, Ralica; id_orcid, Cromb, Daniel, Rutherford, Mary; id_orcid   +17 more
core   +1 more source

Longitudinal MRI studies of children with attention‐deficit/hyperactivity disorder: A systematic review

Psychiatry and Clinical Neurosciences, Volume 80, Issue 10, Page 789-812, October 2026.
We reviewed longitudinal magnetic resonance imaging (MRI) studies exploring the brain development of children with attention‐deficit/hyperactivity disorder (ADHD). Specifically, we conducted a systematic review of papers published until 9 September 2025 in English on pediatric patients with ADHD.
Ayaka Ishii‐Takahashi, Yuzu Yoshimaru, Dwi Muhammad, Takuya Kawahara, Rio Yamaguchi   +4 more
wiley   +1 more source

Unveiling MRI markers for Parkinson’s Disease: GABAergic dysfunction and cortical changes

NeuroImage: Clinical
Objective: The study aimed to investigate changes in basal levels of the inhibitory γ-aminobutyric acid (GABA) neurotransmitter in the sensorimotor cortex (SMC) and cortical gyrification in patients with Parkinson’s disease (PD), which could further ...
Yuan Tian, Sijia Geng, Tianyi Liu, Qi Wang, Jianxiu Lian, Liangjie Lin, Jiayu Li, Tao Gong, Junhong Duan, Dan Wang, Pengfei Liu   +10 more
doaj   +1 more source

Gyrification Index and Encephalizaton Quotient of Brain of Surti Buffalo (Bubalus bubalis)

THE INDIAN JOURNAL OF VETERINARY SCIENCES AND BIOTECHNOLOGY, 2018
The brain of Surti buffaloes presents many cortical foldings. These are called gyrification. In the present study on brain of 12 Surti buffaloes, the folded cerebral hemispheres presented various sulci and gyri of different sizes. Gyrification Index (GI) was measured by the sum of the complete exposed surface and superficially exposed surface of ...
Alka Suman, Sweta Pandya
openaire   +1 more source

The Baboon as a Model to Study Human Health and Complex Disease

American Journal of Primatology, Volume 88, Issue 9, September 2026.
Baboons remain underappreciated as models of human biology and disease offering a distinct combination of biological and practical properties. In this review, we evaluate the baboon as a model for human complex diseases and make the case for broader use of baboons in translational research.
Brittany Hazzard, Yoav Gilad
wiley   +1 more source

Crosstalk Between Cortical Plasticity and Peripheral Nervous Injury: Insights, Mechanisms, and Future Directions

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Peripheral nerve injury induces dynamic cortical plasticity, driven by molecular mechanisms such as BDNF and neurotransmitter systems. This review synthesizes subtype‐specific plasticity patterns: compressive injuries trigger rapid reorganization, while metabolic neuropathies lead to maladaptive changes.
Cong Cheng, Dong Gao, Yaojie Shen, Xi Wang, Junxi Dai, Yaoxian Xiang, Zongyuan Jiang, Zongqi You, Junjian Jiang   +8 more
wiley   +1 more source