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Trends in Biochemical Sciences, 1989
Since the pioneering work of Peter Mitchell 1, the central role of proton gradients in biological energy transduc- tion has been widely ackrLowledged. The enzymes directly involved in generating and harnessing the energy of proton gradients (H+-ATPases), are found in nearly all cells and presumably appeared very early in cell evolution 2.
N, Nelson, L, Taiz
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Since the pioneering work of Peter Mitchell 1, the central role of proton gradients in biological energy transduc- tion has been widely ackrLowledged. The enzymes directly involved in generating and harnessing the energy of proton gradients (H+-ATPases), are found in nearly all cells and presumably appeared very early in cell evolution 2.
N, Nelson, L, Taiz
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Inherited disorders of the H+-ATPase
Current Opinion in Nephrology and Hypertension, 2002The alpha-intercalated cell in the distal nephron shares a number of molecular features with the osteoclast, including site-limited proton pumps that are present at high density. These are multisubunit H -ATPases, which are essential for acid-base homeostasis and for the maintenance of normal bone turnover.
Katherine J, Borthwick, Fiona E, Karet
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Structure and function of H+-ATPase
Journal of Bioenergetics and Biomembranes, 1979(1) Extensive studies on proton-translocating ATPase (H+-ATPase) revealed that H+-ATPase is an energy transforming device universally distributed in membranes of almost all kinds of cells. (2) Crystallization of the catalytic portion (F1) of H+-ATPase showed that F1 is a hexagonal molecule with a central hole.
Y, Kagawa +3 more
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Vacuolar H+-ATPase Signaling Pathway in Cancer
Current Protein & Peptide Science, 2012Up-regulated aerobic glycolysis is a hallmark of malignant cancers. Little is understood about the reasons why malignant tumors up-regulate glycolysis and acidify their microenvironment. Signaling pathways involved in glucose changes are numerous. However, the identity of the internal glucose signal remains obscure.
Souad R, Sennoune +1 more
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Selective Inhibition of Osteoclast Vacuolar H+-ATPase
Current Pharmaceutical Design, 2002The proton pump expressed on the plasma membrane of bone resorbing osteoclasts, and which mediates the acidification of the extracellular environment in resorption lacuna, belongs to the family of vacuolar H(+)-ATPases, which are enzymes ubiquitously distributed among all cells and are evolutionary conserved.
Carlo, Farina, S, Gagliardi
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Intrinsic Fluorescence of the Chloroplast H+-ATPase
Archives of Biochemistry and Biophysics, 1995We have examined the intrinsic fluorescence properties of a highly purified chloroplast H(+)-ATPase (CF0F1) preparation [R. D. Kirch and P. Graber (1992) Acta Physiol. Scand. 746, 9-12). Unlike the catalytic CF1 portion alone, CF0F1 fluorescence was dominated by tryptophan fluorescence both at 277-nm excitation, favoring tyrosine excitation, and at 295-
Kirch, Robert Dale +3 more
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Kidney Vacuolar H+-ATPase: Physiology and Regulation
Seminars in Nephrology, 2006The vacuolar H(+)-ATPase is a multisubunit protein consisting of a peripheral catalytic domain (V(1)) that binds and hydrolyzes adenosine triphosphate (ATP) and provides energy to pump H(+) through the transmembrane domain (V(0)) against a large gradient.
Patricia, Valles +3 more
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Thermal stability of soluble mitochondrial H+-ATPase
Biophysics of Structure and Mechanism, 1979ATPase melting has been studied by circular dichroism and differential scanning microcalorimetry. Decomposition of the alpha-helix of H+-ATPase (in which about 80% of the peptide groups of the enzyme are involved) following thermal treatment is shown to proceed gradually, beginning with room temperature.
A A, Kiladze +3 more
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Cellular physiology of the renal H+ATPase
Current Opinion in Nephrology and Hypertension, 2009Vacuolar-type H+ATPases are multisubunit macromolecules that play an essential role in renal acid-base homeostasis. Other cellular processes also rely on the proton pumping ability of H+ATPases to acidify organellar or lumenal spaces. Several diseases, including distal renal tubular acidosis, osteoporosis and wrinkly skin syndrome, are due to mutations
Katherine G, Blake-Palmer +1 more
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2014
Vacuolar H+-ATPase Assembly Structure of Prokaryotic V type ATPase/synthase The function of V-ATPase in the degradation of gluconeogenic enzymes in the yeast vacuole The Role of Vacuolar ATPase in the Regulation of Npt2a Trafficking Cytosolic pH regulated by glucose promotes V-ATPase assembly Vacuolar H+-ATPase (V-ATPase) activated by glucose, a ...
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Vacuolar H+-ATPase Assembly Structure of Prokaryotic V type ATPase/synthase The function of V-ATPase in the degradation of gluconeogenic enzymes in the yeast vacuole The Role of Vacuolar ATPase in the Regulation of Npt2a Trafficking Cytosolic pH regulated by glucose promotes V-ATPase assembly Vacuolar H+-ATPase (V-ATPase) activated by glucose, a ...
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