Results 51 to 60 of about 1,008,634 (300)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Hölder continuity of weak solution to a nonlinear problem with non-standard growth conditions

open access: yesBoundary Value Problems, 2018
We study the Hölder continuity of weak solution u to an equation arising in the stationary motion of electrorheological fluids. To this end, we first obtain higher integrability of Du in our case by establishing a reverse Hölder inequality.
Zhong Tan, Jianfeng Zhou, Wenxuan Zheng
doaj   +1 more source

Classical Solutions to the Initial-Boundary Value Problems for Nonautonomous Fractional Diffusion Equations

open access: yesComplexity, 2020
In this paper, we investigate a class of nonautonomous fractional diffusion equations (NFDEs). Firstly, under the condition of weighted Hölder continuity, the existence and two estimates of classical solutions are obtained by virtue of the properties of ...
Jia Mu, Yang Liu, Huanhuan Zhang
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Holder continuity with exponent (1+alpha)/2 in the time variable for solutions of parabolic equations

open access: yesElectronic Journal of Differential Equations, 2015
We consider the regularity of solutions for some parabolic equations. We show Holder continuity with exponent $(1+\alpha )/2$, with respect to the time variable, when the gradient in the space variable of the solution has the Holder continuity with ...
Junichi Aramaki
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Hölder continuity and upper estimates of solutions to vector quasiequilibrium problems

open access: yes, 2011
In this paper, we establish the Hölder continuity of solution mappings to parametric vector quasiequilibrium problems in metric spaces under the case that solution mappings are set-valued. Our main assumptions are weaker than those in the literature, and
Li, S.   +7 more
core   +2 more sources

An alternative approach to partial regularity of quasilinear elliptic systems with VMO coefficients

open access: yesJournal of Inequalities and Applications, 2016
In this paper, we provide an alternative approach to partially Hölder continuity of some quasilinear elliptic systems with discontinuous coefficients under natural growth.
Haiyan Yu, Shenzhou Zheng, Yuxia Tong
doaj   +1 more source

Hölder continuity for second order elliptic problems with nonsmooth data [PDF]

open access: yes, 2008
The well known De Giorgi result on Hölder continuity for solutions of the Dirichlet problem is re-established for mixed boundary value problems, provided that the underlying domain is a Lipschitz domain and the border between the Dirichlet and the ...
Haller-Dintelmann, Robert   +2 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

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