Results 61 to 70 of about 7,321 (260)

From β to η: a new cohomology for deformed Sasaki-Einstein manifolds

open access: yesJournal of High Energy Physics, 2022
We discuss in detail the different analogues of Dolbeault cohomology groups on Sasaki-Einstein manifolds and prove a new vanishing result for the transverse Dolbeault cohomology groups H ∂ ¯ p 0 k $$ {H}_{\overline{\partial}}^{\left(p,0\right)}(k ...
Edward Lødøen Tasker
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Flow field and noise characteristics of manifold in natural gas transportation station

open access: yesOil & Gas Science and Technology, 2019
Manifolds play a role of pressure balance, buffering and rectification for different branch pipelines, the flow noise of manifolds has been a serious problem all this time in natural gas transmission station.
Su Zhongya   +5 more
doaj   +1 more source

Hyperkahler Cones and Orthogonal Wolf Spaces

open access: yes, 2002
We construct the hyperkahler cones corresponding to the Quaternion-Kahler orthogonal Wolf spaces SO(n+4)/(SO(n)xSO(4)) and their non-compact versions, which appear in hypermultiplet couplings to N=2 supergravity.
Anguelova, Lilia   +2 more
core   +2 more sources

The intrinsic torsion of almost quaternion-Hermitian manifolds [PDF]

open access: yes, 2007
We study the intrinsic torsion of almost quaternion-Hermitian manifolds via the exterior algebra. In particular, we show how it is determined by particular three-forms formed from simple combinations of the exterior derivatives of the local Kaehler forms.
Cabrera, Francisco Martin, Swann, Andrew
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Berry phase in graphene: a semiclassical perspective

open access: yes, 2008
We derive a semiclassical expression for the Green's function in graphene, in which the presence of a semiclassical phase is made apparent. The relationship between this semiclassical phase and the adiabatic Berry phase, usually referred to in this ...
C. Berger   +5 more
core   +1 more source

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