Results 61 to 70 of about 25,699,961 (309)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Complex quaternionic manifolds and C-projective structures
Complex ManifoldsWe discuss complex quaternionic manifolds, i.e., those that have holonomy GL(n,H)U(1) $GL\left(n,\mathbb{H}\right)U\left(1\right)$ , which naturally arise via quaternionic Feix–Kaledin construction.
Borówka Aleksandra
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Square-integrability of solutions of the Yamabe equation [PDF]
, 2011 We show that solutions of the Yamabe equation on certain n- dimensional non-compact Riemannian manifolds which are bounded and Lp for p = 2n=(n-2) are also L2. This Lp-L2-implication provides explicit constants in the surgery-monotonicity formula for the
Humbert, Emmanuel +3 more
core +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Separating manifolds in slow-fast systems [PDF]
, 2005 There are many applications that lead to models involving different timescales. For example, this is particularly the case for models of neurons, which involve dynamics of ionic channels across the cell membrane.
England, James, Osinga, HM
core
Geodesic Monte Carlo on Embedded Manifolds [PDF]
, 2013 Markov chain Monte Carlo methods explicitly defined on the manifold of probability distributions have recently been established. These methods are constructed from diffusions across the manifold and the solution of the equations describing geodesic flows
Simon Byrne +5 more
core +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
H-contact semi-Riemannian manifolds [PDF]
, 2013 We characterize H-contact semi-Riemannian manifolds (i.e., contact semi-Riemannian manifolds whose Reeb vector field ξ is harmonic) by the condition that ξ is a Ricci eigenvector. We then investigate how H-contact semi-Riemannian manifolds are related to
CALVARUSO, Giovanni, PERRONE, Domenico
core +1 more source
From β to η: a new cohomology for deformed Sasaki-Einstein manifolds
Journal of High Energy Physics, 2022 We discuss in detail the different analogues of Dolbeault cohomology groups on Sasaki-Einstein manifolds and prove a new vanishing result for the transverse Dolbeault cohomology groups H ∂ ¯ p 0 k $$ {H}_{\overline{\partial}}^{\left(p,0\right)}(k ...
Edward Lødøen Tasker
doaj +1 more source