Results 81 to 90 of about 19,217,453 (333)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Probe Measurement in H-mode [PDF]
Probe Measurement in H-modeA. Komori +4 more
openaire +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Empirical scaling of the L–H threshold power for metal wall tokamaks using a multi-device database
Nuclear FusionThe empirical scaling for the H-mode power threshold in tokamaks has been revisited using a database with threshold data from machines with a metallic first wall as part of International Tokamak Physics Activity (ITPA) task TC-26.
E. Delabie +14 more
doaj +1 more source
Flexible Spacecraft Attitude Control using Hybrid Control Scheme of Hâ and Sliding Mode Control [PDF]
فصلنامه علوم و فناوری فضایی, 2008 In this paper, based on the Lagrange method, attitude motion equations for a flexible spacecraft have been derived. Flexible appendages are modeled by Euler-Bernoulli beam.
M. Sayanjali, J. Roshanian, A. Ghafari
doaj
Nuclear Fusion, 2023 The quasi-coherent mode (QCM), appearing in enhanced D $_{\alpha}$ high confinement mode (EDA H-mode) and quasi-continuous exhaust (QCE) plasmas has been analysed in detail at ASDEX Upgrade via thermal helium beam spectroscopy under various discharge ...
J. Kalis +14 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Poloidal structure of the edge parallel flow in H-mode, L-mode and I-mode confinement regimes
Nuclear FusionImpurity profiles have been measured with the edge high field side (HFS) and low field side (LFS) charge exchange recombination spectroscopy suite at ASDEX Upgrade enabling the study of the poloidal structure of the edge parallel flow in H-mode, L-mode ...
D.J. Cruz-Zabala +10 more
doaj +1 more source