Results 131 to 140 of about 4,465 (182)
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H1-antihistamines in children.
Clinical allergy and immunology, 2002In children, as in adults, H1-antagonists are useful in the treatment of allergic rhinoconjunctivitis. Level 1 evidence for their efficacy in this disorder has been obtained in many well-designed pediatric studies. The widespread use of H1-antagonists in upper respiratory tract infections or otitis media in children is not supported by a strong ...
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Pharmacokinetic-Pharmacodynamic Relationships of H1-Antihistamines
Clinical Pharmacokinetics, 1995Histamine H1-receptor antagonists are reversible, competitive inhibitors of the actions of histamine, a critical mediator in the pathophysiology of the allergic response. This review is mainly devoted to second generation antihistamines that possess a low sedation potential compared with first generation compounds.
J P, Desager, Y, Horsmans
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Eosinophil infiltration: Effects of H1 antihistamines
Journal of the American Academy of Dermatology, 1991This article reviews the contribution of cell-mediated inflammatory responses to the immediate immunoglobulin E-dependent allergic reaction. Apparently eosinophils play an important part in the pathogenesis of allergic reactions. Some new H1 antihistamines may also have non-H1-mediated antiinflammatory properties.
R, Fadel +5 more
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Amide derivatives with H1-antihistaminic effect
Pharmaceutica Acta Helvetiae, 1998The synthesis and the structure-activity correlation of a series of N-aminoalkylacetamides as H1-antihistaminic agents have been carried out. The compounds were tested in vitro by measurement of the inhibition of histamine-induced contractions on isolated guinea pig ileum; the results are expressed as pA2.
C, Saturnino +6 more
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Efficacy and Safety of H1-Antihistamines: An Update
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2012H1-antihistamines are inverse agonists that combine with and stabilize inactive conformation of H1-receptors. Thus they interfere with actions of histamine at H1-receptors. They are widely used for treatment of allergic rhinitis, allergic conjunctivitis, urticaria, coughs, colds and insomnia. H1-antihistamines are classified as older 'first generation'
Fusun, Kalpaklioglu, Ayse, Baccioglu
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Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery, 2013
While histamine plays an important role in the pathogenesis of allergic diseases, such as allergic rhinitis, H1-antihistamines, which have been using in the treatment of allergic diseases for more than 70 years, are considered as the cornerstone of the medication of allergic diseases. In this review, we discuss the history of histamine studies and anti-
Luo, Zhang, Demin, Han
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While histamine plays an important role in the pathogenesis of allergic diseases, such as allergic rhinitis, H1-antihistamines, which have been using in the treatment of allergic diseases for more than 70 years, are considered as the cornerstone of the medication of allergic diseases. In this review, we discuss the history of histamine studies and anti-
Luo, Zhang, Demin, Han
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Clinical pharmacology of H1-antihistamines in the skin
Journal of Allergy and Clinical Immunology, 2002The extent of the distribution of H(1)- antihistamines into the skin and H(1)-antihistamine activity in the skin are clinically relevant in the treatment of allergic skin disorders.In a prospective, randomized, double-blind, parallel-group, multiple-dose study, we gave fexofenadine 180 mg, loratadine 10 mg, or chlorpheniramine 8 mg to 21 men (7 in each
F Estelle R, Simons +3 more
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Clinical Pharmacology of H1-Antihistamines
Clinical allergy and immunology, 2002H1-antagonists have similar efficacy in the treatment of patients with allergic rhinitis or urticaria; however, they are diverse with regard to their chemical structure (Fig. 1), clinical pharmacology, and potential for toxicity (1). The scientific foundation for using these medications with optimal effectiveness in all patient populations, including the
F Estelle R, Simons, Keith J, Simons
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Pharmacology of Non-Sedating H1 Antihistamines
1991A review of the preclinical pharmacology of non-sedating H1 antihistamines includes comparative data on potency, duration of action, side effect liability, especially CNS depressant and anticholinergic activity and new approaches that may further enhance the efficacy of these newer compounds.
A, Barnett, W, Kreutner
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[Nonsedative H1 antihistaminics].
Casopis lekaru ceskych, 1991Recent research provided evidence that effective H1-antihistaminic drugs need not exert a central and sedative action. Non-sedative H1-antihistaminics can aptly replace older combined preparations of classical H1-antihistaminics, motivated by an effort to weaken their sedative action by the concurrent administration of pharmaceutical preparations with ...
H, Blehová, J, Metys
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