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H1-antihistamines in pregnancy and lactation.
Clinical allergy and immunology, 2002Antihistamines may be used for the treatment of allergic rhinitis, upper respiratory infections, urticaria/angioedema, atopic dermatitis, and, rarely, as adjunctive treatment for anaphylaxis, during pregnancy. Because these illnesses may affect maternal comfort and safety as well as threaten the fetus directly (anaphylaxis) or indirectly, they often ...
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Modern H1-antihistamines in asthma
Drug Discovery Today: Therapeutic Strategies, 2006The extensively documented antiallergic and anti-inflammatory properties of second-generation H 1 -antihistamines further enhance their therapeutic potential in asthma. Modern H 1 -antihistamines such as desloratadine, fexofenadine and levocetirizine, with wider therapeutic windows and similar antiallergic and anti-inflammatory properties as the older ...
Prashant S. Borade +3 more
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H1-Antihistamine Premedication in NSAID-Associated Urticaria
The Journal of Allergy and Clinical Immunology: In Practice, 2016Therapeutic options for pain management are restricted in patients with nonsteroidal anti-inflammatory drug (NSAID)-induced or NSAID-exacerbated urticaria because strong cyclooxygenase (COX)-I inhibiting NSAID cannot be used. Alternative NSAID such as weak COX-I inhibitors or selective COX-II inhibitors are sometimes not sufficiently effective or have ...
Axel, Trautmann +2 more
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Novel benzothiophene H1-antihistamines for the treatment of insomnia
Bioorganic & Medicinal Chemistry Letters, 2010SAR of lead benzothiophene H(1)-antihistamine 2 was explored to identify backup candidates with suitable pharmacokinetic profiles for an insomnia program. Several potent and selective H(1)-antihistamines with a range of projected half-lives in humans were identified. Compound 16d had a suitable human half-life as demonstrated in a human microdose study,
Wilna J, Moree +19 more
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Cost-effectiveness of H1-antihistamines.
Clinical allergy and immunology, 2002In the health care arena, assessment of a medication's clinical efficacy is no longer enough. It is important to confirm the medication's cost-effectiveness and the improvement in quality of life it provides in relationship to other options in therapy.
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Comparative safety of H1 antihistamines.
Annals of allergy, 1992In the allergic reaction, mast cells degranulate, releasing inflammatory mediators including histamine. The H1 receptor antihistamines have been developed over the past 50 years to minimize the clinical symptoms caused by this reaction. Currently, H1 antihistamines are taken by approximately 30 million Americans per year.
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Paradoxical urticaria to H1‐antihistamines
Journal of the European Academy of Dermatology and VenereologyAngèle Soria +5 more
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