Results 1 to 10 of about 47,678 (217)

Antitumor Activity of Isalpinin from Paphiopedilum dianthum on Non-Small Cell Lung Cancer Cell Lines [PDF]

Molecules
Lung cancer is a leading cause of cancer-related deaths globally, with current treatments having significant limitations, including drug resistance, metastasis, and tumor heterogeneity.
Phisit Pouyfung, Nonthalert Lertnitikul, Hua Bai, Achitphol Chookaew, Varisa Pongrakhananon, Piriya Chonsut, Suwichak Chaisit   +6 more
doaj   +2 more sources

KRAS G12C inhibition enhances efficacy to conventional chemotherapy in KRAS-mutant NSCLC [PDF]

Frontiers in Oncology
Despite recent therapeutic advances, the adjuvant treatment of non-small cell lung cancer (NSCLC) remains a challenge. Reducing the risk of recurrence is still a concern, especially in the KRAS G12C population, for which platinum-based adjuvant ...
Alessandro Tubita, Sara Fancelli, Lorenzo Anela, Giulia Petroni, Enrico Caliman, Francesca Mazzoni, Federico Scolari, Brunella Napolitano, Beatrice Menicacci, Camilla Eva Comin, Luca Voltolini, Serena Pillozzi, Lorenzo Antonuzzo, Lorenzo Antonuzzo   +13 more
doaj   +2 more sources

Panobinostat potentiates adagrasib-induced cell death by triggering autophagy in human non-small cell lung cancer [PDF]

Cell Death Discovery
Adagrasib, a KRASG12C inhibitor, recently received accelerated approval from the US FDA for the treatment of patients diagnosed with KRASG12C-mutated non-small cell lung cancer.
Hui Lu, Wenying Fu, Yiqun Xia, Ying Yan, Chongchong Shu, Yinghua Chen, Chenxin Xu, Peisen Zheng, Xin Shen, Ri Cui, Peng Zou, Daoyong Ni   +11 more
doaj   +2 more sources

Less workplace parking with fully autonomous vehicles? [PDF]

Journal of Intelligent and Connected Vehicles, 2022
Purpose – Recent studies on commuter parking in an age of fully autonomous vehicles (FAVs) suggest, that the number of parking spaces close to the workplace demanded by commuters will decline because of the capability of FAVs to return home, to seek out (
Stefan Tscharaktschiew, Felix Reimann
doaj   +1 more source

Capsaicin induces ferroptosis of NSCLC by regulating SLC7A11/GPX4 signaling in vitro

Scientific Reports, 2022
NSCLC is the first cause of cancer-related deaths in China and threatens life expectancy of the people. Novel drugs and treatment strategies are urgently required.
Xiao-Yan Liu, Dong-Guang Wei, Rong-Shan Li   +2 more
doaj   +1 more source

A study of PD-L1 expression in KRAS mutant non-small cell lung cancer cell lines exposed to relevant targeted treatments. [PDF]

PLoS ONE, 2017
We investigated PD-L1 changes in response to MEK and AKT inhibitors in KRAS mutant lung adenocarcinoma (adeno-NSCLC). PD-L1 expression was quantified using immunofluorescence and co-culture with a jurkat cell-line transfected with NFAT-luciferase was ...
Anna Minchom, Parames Thavasu, Zai Ahmad, Adam Stewart, Alexandros Georgiou, Mary E R O'Brien, Sanjay Popat, Jaishree Bhosle, Timothy A Yap, Johann de Bono, Udai Banerji   +10 more
doaj   +1 more source

Effectiveness of environmental policies on carbon emissions: A panel threshold analysis

Economics and Business Review, 2022
The aim of this study is to test the possible non-linear effect of environmental policy stringency on carbon emissions and thus make policy recommendations for emission reduction.
Akbulut Hale
doaj   +1 more source

Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
As one of the most lethal malignancies, lung cancer is considered to account for approximately one-fifth of all malignant tumours-related deaths worldwide.
Mohammad M. Al-Sanea, Ghada H. Al-Ansary, Zainab M. Elsayed, Raed M. Maklad, Eslam B. Elkaeed, Mohamed A. Abdelgawad, Syed Nasir Abbas Bukhari, Marwa M. Abdel-Aziz, Howayda Suliman, Wagdy M. Eldehna   +9 more
doaj   +1 more source

CS-PEI/Beclin-siRNA Downregulate Multidrug Resistance Proteins and Increase Paclitaxel Therapeutic Efficacy against NSCLC

Molecular Therapy: Nucleic Acids, 2019
Paclitaxel (PTX) is a widely used chemotherapy drug; however, frequent use causes multidrug resistance (MDR), which limits the utility of PTX against advanced non-small-cell lung cancer (NSCLC).
Wangta Liu, Yu-Lun Lo, Chin Hsu, Yi-Ting Wu, Zi-Xian Liao, Wen-Jeng Wu, Yi-Jou Chen, Chieh Kao, Chien-Chih Chiu, Li-Fang Wang   +9 more
doaj   +1 more source

Non-Abelian Flat Directions in a Minimal Superstring Standard Model [PDF]

, 2000
Recently, by studying exact flat directions of non-Abelian singlet fields, we demonstrated the existence of free fermionic heterotic-string models in which the SU(3)_C x SU(2)_L x U(1)_Y-charged matter spectrum, just below the string scale, consists ...
A. E. FARAGGI, D. V. NANOPOULOS, Ellis J., Faraggi A. E., G. B. CLEAVER, Horava P., J. W. WALKER   +6 more
core   +4 more sources