Results 1 to 10 of about 15,539 (167)

Antitumor Activity of Isalpinin from Paphiopedilum dianthum on Non-Small Cell Lung Cancer Cell Lines [PDF]

Molecules
Lung cancer is a leading cause of cancer-related deaths globally, with current treatments having significant limitations, including drug resistance, metastasis, and tumor heterogeneity.
Phisit Pouyfung, Nonthalert Lertnitikul, Hua Bai, Achitphol Chookaew, Varisa Pongrakhananon, Piriya Chonsut, Suwichak Chaisit   +6 more
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KRAS G12C inhibition enhances efficacy to conventional chemotherapy in KRAS-mutant NSCLC [PDF]

Frontiers in Oncology
Despite recent therapeutic advances, the adjuvant treatment of non-small cell lung cancer (NSCLC) remains a challenge. Reducing the risk of recurrence is still a concern, especially in the KRAS G12C population, for which platinum-based adjuvant ...
Alessandro Tubita, Sara Fancelli, Lorenzo Anela, Giulia Petroni, Enrico Caliman, Francesca Mazzoni, Federico Scolari, Brunella Napolitano, Beatrice Menicacci, Camilla Eva Comin, Luca Voltolini, Serena Pillozzi, Lorenzo Antonuzzo, Lorenzo Antonuzzo   +13 more
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Bioactive black tea phytochemicals partially influenced doxorubicin sensitivity by modulation of NRF2-regulatory pathways in lung cancer [PDF]

Journal of Ayurveda and Integrative Medicine
Background: Lung cancer therapy resistance is often associated with the redox-regulatory nuclear factor erythroid 2-related factor-2 (NRF2)-Kelch-like ECH-associated protein1 (KEAP1) dysfunction.
Suchisnigdha Datta, Anupam Bishayee, Dona Sinha   +2 more
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Panobinostat potentiates adagrasib-induced cell death by triggering autophagy in human non-small cell lung cancer [PDF]

Cell Death Discovery
Adagrasib, a KRASG12C inhibitor, recently received accelerated approval from the US FDA for the treatment of patients diagnosed with KRASG12C-mutated non-small cell lung cancer.
Hui Lu, Wenying Fu, Yiqun Xia, Ying Yan, Chongchong Shu, Yinghua Chen, Chenxin Xu, Peisen Zheng, Xin Shen, Ri Cui, Peng Zou, Daoyong Ni   +11 more
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Less workplace parking with fully autonomous vehicles? [PDF]

Journal of Intelligent and Connected Vehicles, 2022
Purpose – Recent studies on commuter parking in an age of fully autonomous vehicles (FAVs) suggest, that the number of parking spaces close to the workplace demanded by commuters will decline because of the capability of FAVs to return home, to seek out (
Stefan Tscharaktschiew, Felix Reimann
doaj   +1 more source

Capsaicin induces ferroptosis of NSCLC by regulating SLC7A11/GPX4 signaling in vitro

Scientific Reports, 2022
NSCLC is the first cause of cancer-related deaths in China and threatens life expectancy of the people. Novel drugs and treatment strategies are urgently required.
Xiao-Yan Liu, Dong-Guang Wei, Rong-Shan Li   +2 more
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A study of PD-L1 expression in KRAS mutant non-small cell lung cancer cell lines exposed to relevant targeted treatments. [PDF]

PLoS ONE, 2017
We investigated PD-L1 changes in response to MEK and AKT inhibitors in KRAS mutant lung adenocarcinoma (adeno-NSCLC). PD-L1 expression was quantified using immunofluorescence and co-culture with a jurkat cell-line transfected with NFAT-luciferase was ...
Anna Minchom, Parames Thavasu, Zai Ahmad, Adam Stewart, Alexandros Georgiou, Mary E R O'Brien, Sanjay Popat, Jaishree Bhosle, Timothy A Yap, Johann de Bono, Udai Banerji   +10 more
doaj   +1 more source

Effectiveness of environmental policies on carbon emissions: A panel threshold analysis

Economics and Business Review, 2022
The aim of this study is to test the possible non-linear effect of environmental policy stringency on carbon emissions and thus make policy recommendations for emission reduction.
Akbulut Hale
doaj   +1 more source

Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
As one of the most lethal malignancies, lung cancer is considered to account for approximately one-fifth of all malignant tumours-related deaths worldwide.
Mohammad M. Al-Sanea, Ghada H. Al-Ansary, Zainab M. Elsayed, Raed M. Maklad, Eslam B. Elkaeed, Mohamed A. Abdelgawad, Syed Nasir Abbas Bukhari, Marwa M. Abdel-Aziz, Howayda Suliman, Wagdy M. Eldehna   +9 more
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Different RONS Generation in MTC-SK and NSCL Cells Lead to Varying Antitumoral Effects of Alpha-Ketoglutarate + 5-HMF

Current Issues in Molecular Biology, 2023
Background: Carbonylated proteins (CPs) serve as specific indicators of increased reactive oxygen and nitrogen species (RONS) production in cancer cells, attributed to the dysregulated mitochondrial energy metabolism known as the Warburg effect.
Joachim Greilberger, Katharina Erlbacher, Philipp Stiegler, Reinhold Wintersteiger, Ralf Herwig   +4 more
doaj   +1 more source