Results 21 to 30 of about 17,190 (226)

Microarray Identifies a Key Carcinogenic Circular RNA 0008594 That Is Related to Non-Small-Cell Lung Cancer Development and Lymph Node Metastasis and Promotes NSCLC Progression by Regulating the miR-760-Mediated PI3K/AKT and MEK/ERK Pathways

open access: yesFrontiers in Oncology, 2021
PurposeThis study aimed to explore the circular RNA (circRNA/circ) profile engaged in non-small cell lung cancer (NSCLC) development and metastasis and to investigate potentially key carcinogenic circRNAs related to NSCLC.MethodsCircRNA profiles between ...
Qiushi Wang   +8 more
doaj   +1 more source

A study of PD-L1 expression in KRAS mutant non-small cell lung cancer cell lines exposed to relevant targeted treatments. [PDF]

open access: yesPLoS ONE, 2017
We investigated PD-L1 changes in response to MEK and AKT inhibitors in KRAS mutant lung adenocarcinoma (adeno-NSCLC). PD-L1 expression was quantified using immunofluorescence and co-culture with a jurkat cell-line transfected with NFAT-luciferase was ...
Anna Minchom   +10 more
doaj   +1 more source

Different RONS Generation in MTC-SK and NSCL Cells Lead to Varying Antitumoral Effects of Alpha-Ketoglutarate + 5-HMF

open access: yesCurrent Issues in Molecular Biology, 2023
Background: Carbonylated proteins (CPs) serve as specific indicators of increased reactive oxygen and nitrogen species (RONS) production in cancer cells, attributed to the dysregulated mitochondrial energy metabolism known as the Warburg effect.
Joachim Greilberger   +4 more
doaj   +1 more source

Development of 3-methyl/3-(morpholinomethyl)benzofuran derivatives as novel antitumor agents towards non-small cell lung cancer cells

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2021
As one of the most lethal malignancies, lung cancer is considered to account for approximately one-fifth of all malignant tumours-related deaths worldwide.
Mohammad M. Al-Sanea   +9 more
doaj   +1 more source

MiR-326 mediates malignant biological behaviors of lung adenocarcinoma by targeting ZEB1

open access: yesScience Progress, 2021
MiR-326 functions as an antioncogene in the several types of cancer. However, the underling mechanisms through which miRNA-326 regulates the anti-carcinogenesis of lung adenocarcinoma have remained elusive.
Mingxin Liu   +11 more
doaj   +1 more source

CS-PEI/Beclin-siRNA Downregulate Multidrug Resistance Proteins and Increase Paclitaxel Therapeutic Efficacy against NSCLC

open access: yesMolecular Therapy: Nucleic Acids, 2019
Paclitaxel (PTX) is a widely used chemotherapy drug; however, frequent use causes multidrug resistance (MDR), which limits the utility of PTX against advanced non-small-cell lung cancer (NSCLC).
Wangta Liu   +9 more
doaj   +1 more source

Rethinking classifications and metrics for problematic smartphone use and dependence: Addressing the call for reassessment

open access: yesComputers in Human Behavior Reports, 2023
Despite numerous favourable consequences, excessive smartphone usage has been linked to behaviours that might be detrimental or unsettling, at least for some individuals.
Saqib Nawaz
doaj   +1 more source

Skill Mapping, Talent Pool Management and Organisational Development: Evidence from Professional Bodies in Nigeria

open access: yesEconomics and Business, 2020
The study examined the influence of skill mapping and talent pool management on organisational development in Nigeria. The study adopted a survey research and the study population comprised three thousand (3000) active members of Chartered Institute of ...
Abioro Matthew Adekunle   +3 more
doaj   +1 more source

Effect of Informal Sector Tax Revenue on Capital Development in Lagos Metropolis

open access: yesEconomics and Business, 2020
The study investigates the effect of informal sector tax proceeds on capital development in Lagos Metropolis. The study adopted Ex-post facto design to obtain secondary data, covering 20 years (2000–2019) from the Lagos State Internal Revenue Service and
Olabisi Jayeola   +3 more
doaj   +1 more source

Glycyrrhizin Suppresses Lung Adenocarcinoma Cell Growth Through Inhibition of Thromboxane Synthase

open access: yesCellular Physiology and Biochemistry, 2014
Background/Aims: The effects of glycyrrhizin treatment in lung cancer remain undetermined, despite extensive studies of the anti-tumor activities of glycyrrhizin. Methods: Lung adenocarcinoma A549 and NCI-H23 cell lines were used in this study.
Run-Yue Huang   +5 more
doaj   +1 more source

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