Results 11 to 20 of about 17,190 (226)

Capsaicin induces ferroptosis of NSCLC by regulating SLC7A11/GPX4 signaling in vitro

Scientific Reports, 2022
NSCLC is the first cause of cancer-related deaths in China and threatens life expectancy of the people. Novel drugs and treatment strategies are urgently required.
Xiao-Yan Liu, Dong-Guang Wei, Rong-Shan Li   +2 more
doaj   +2 more sources

Apigenin promotes cell death in NCI-H23 cells by upregulation of PTEN: potential involvement of the binding of apigenin with WWP2 protein

Journal of Biomolecular Structure and Dynamics, 2023
The tumour suppressor protein PTEN is often down-regulated in non-small cell lung cancer. A major protein promoting the lowering of the PTEN protein is WWP2. Polyphenols have been shown to promote the expression of tumour suppressor genes like PTEN.
Sapna Mayuri Borah, Lakhon Kma, Muskan Sonam Darjee, Dikshit Deka, Anisha Lyngdoh, Rajesh N. Sharan, Taranga Jyoti Baruah   +6 more
openaire   +3 more sources

Antitumor Activity of Isalpinin from Paphiopedilum dianthum on Non-Small Cell Lung Cancer Cell Lines [PDF]

Molecules
Lung cancer is a leading cause of cancer-related deaths globally, with current treatments having significant limitations, including drug resistance, metastasis, and tumor heterogeneity.
Phisit Pouyfung, Nonthalert Lertnitikul, Hua Bai, Achitphol Chookaew, Varisa Pongrakhananon, Piriya Chonsut, Suwichak Chaisit   +6 more
doaj   +2 more sources

KRAS G12C inhibition enhances efficacy to conventional chemotherapy in KRAS-mutant NSCLC [PDF]

Frontiers in Oncology
Despite recent therapeutic advances, the adjuvant treatment of non-small cell lung cancer (NSCLC) remains a challenge. Reducing the risk of recurrence is still a concern, especially in the KRAS G12C population, for which platinum-based adjuvant ...
Alessandro Tubita, Sara Fancelli, Lorenzo Anela, Giulia Petroni, Enrico Caliman, Francesca Mazzoni, Federico Scolari, Brunella Napolitano, Beatrice Menicacci, Camilla Eva Comin, Luca Voltolini, Serena Pillozzi, Lorenzo Antonuzzo, Lorenzo Antonuzzo   +13 more
doaj   +2 more sources

Bioactive black tea phytochemicals partially influenced doxorubicin sensitivity by modulation of NRF2-regulatory pathways in lung cancer [PDF]

Journal of Ayurveda and Integrative Medicine
Background: Lung cancer therapy resistance is often associated with the redox-regulatory nuclear factor erythroid 2-related factor-2 (NRF2)-Kelch-like ECH-associated protein1 (KEAP1) dysfunction.
Suchisnigdha Datta, Anupam Bishayee, Dona Sinha   +2 more
doaj   +2 more sources

Activation of a Nonexpressed Hypoxanthine Phosphoribosyltransferase Allele in Mutant H23 HeLa Cells by Agents That Inhibit DNA Methylation [PDF]

Molecular and Cellular Biology, 1986
HeLA H23 cells are a mutant female human tumor cell line harboring defective hypoxanthine phosphoribosyltransferase (HPRT; IMP-pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) as a result of a mutation that alters the isoelectric point of the enzyme (G. Milman, E. Lee, G. S. Changas, J. R. McLaughlin, and J. George, Jr., Proc. Natl. Acad. Sci.
Robert Ivarie, J A Morris
exaly   +3 more sources

Panobinostat potentiates adagrasib-induced cell death by triggering autophagy in human non-small cell lung cancer [PDF]

Cell Death Discovery
Adagrasib, a KRASG12C inhibitor, recently received accelerated approval from the US FDA for the treatment of patients diagnosed with KRASG12C-mutated non-small cell lung cancer.
Hui Lu, Wenying Fu, Yiqun Xia, Ying Yan, Chongchong Shu, Yinghua Chen, Chenxin Xu, Peisen Zheng, Xin Shen, Ri Cui, Peng Zou, Daoyong Ni   +11 more
doaj   +2 more sources

NCI-H23 [PDF]

, 2020
openaire   +2 more sources

Less workplace parking with fully autonomous vehicles? [PDF]

Journal of Intelligent and Connected Vehicles, 2022
Purpose – Recent studies on commuter parking in an age of fully autonomous vehicles (FAVs) suggest, that the number of parking spaces close to the workplace demanded by commuters will decline because of the capability of FAVs to return home, to seek out (
Stefan Tscharaktschiew, Felix Reimann
doaj   +1 more source

Effectiveness of environmental policies on carbon emissions: A panel threshold analysis

Economics and Business Review, 2022
The aim of this study is to test the possible non-linear effect of environmental policy stringency on carbon emissions and thus make policy recommendations for emission reduction.
Akbulut Hale
doaj   +1 more source