Results 1 to 10 of about 17,190 (226)

Immunophenotypic, Genetic, and Clinical Features Associated With RUNX1 Mutation in Acute Leukemias and Chronic Myeloid Neoplasms

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction RUNX1 is a commonly mutated transcriptional regulator of hematopoiesis in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Mutated RUNX1 (mRUNX1) may associate with cross‐lineage immunophenotypic aberrancy, presenting potential complications for blast lineage assignment at diagnosis. Methods Clinical and laboratory
Yi Han Xia, Eric McGinnis
wiley   +1 more source

Success by Design: Senior Leadership Perspectives on Optimising the Role of Clinical Nurse Specialists

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To report on the unique perspectives of senior nursing leaders on the value proposition of the Clinical Nurse Specialist (CNS) role, their organisational experience and the barriers and facilitators to optimise and promote the long‐term sustainability.
Sandra B. Lauck, Leah K. Lambert, Natasha Prodan‐Bhalla, Farinaz Havaei, Denise Bryant‐Lukosius, Jagbir Kaur, Kevin Hare, Sherri Lynn Kensall, Becky Palmer, Sally Thorne   +9 more
wiley   +1 more source

Capacidad redistributiva de los gastos fiscales en el contexto de la polarización del ingreso en México, 2008-2012

Economía Teoría y Práctica, 2016
El presente trabajo busca abordar el concepto de gasto fiscal a partir del caso del impuesto negativo por enajenación de gasolinas y diesel en México para destacar su potencial redistributivo y analizar el comportamiento territorial de los niveles de ...
José Luis Manzanares Rivera
doaj  

Peripheral Inflammation and Sleep Loss Induce Coordinated Motivational Changes: An Experimental Two‐Hit Stress Model

Journal of Sleep Research, EarlyView.
ABSTRACT Sleep loss and low‐grade inflammation are common stressors that affect behaviour and recovery needs. To examine their separate and combined effects on motivation for everyday behaviours, we developed a two‐hit experimental model. Participants (N = 56, 31 women) completed three experimental visits: sleep saturation (two nights, 9 h in bed/night)
John Axelsson, Mats Lekander, Camilla I. Svensson, Nils Simon, Alexandra Kuliszkiewicz, Julie Lasselin, Leonie J. T. Balter   +6 more
wiley   +1 more source

Shifting tax burden to top income earners: what is the best way to reduce inequality?

Economics: Journal Articles, 2019
The authors analyze to what extent and how the tax burden should be shifted towards top income earners in order to reduce income inequality. Starting from Lambert and Aronson (Inequality decomposition analysis and the Gini coefficient revisited 1993) and
Onrubia Jorge, Picos Fidel, Rodado María del Carmen   +2 more
doaj   +1 more source

Pediatric transfusion camp: Developing, piloting and evaluation of a Canadian national pediatric transfusion medicine curriculum

Transfusion, EarlyView.
Abstract Background Standardized post‐graduate education in pediatric transfusion medicine remains limited. The objective of this study was to adapt an adult transfusion education program, Transfusion Camp, to include pediatric content and assess knowledge improvement in pediatric subspecialty trainees.
Ines Zuna, Valérie Arsenault, Kimmo Murto, Suzanne Beno, MacGregor Steele, Jennifer Young, Sarah Leir, Angela Punnett, Cheryl Peters, Lucille Barcat, Yulia Lin, Casey Kapitany, Sophie Chargé, Teresa Skelton, Lani Lieberman   +14 more
wiley   +1 more source

MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?

BMC Cancer, 2018
Background Targeted therapies are based on exploiting cancer-cell-specific genetic features or phenotypic traits to selectively kill cancer cells while leaving normal cells unaffected. Oxidative stress is a cancer hallmark phenotype.
Hussein H. K. Abbas, Kheloud M. H. Alhamoudi, Mark D. Evans, George D. D. Jones, Steven S. Foster   +4 more
doaj   +1 more source

Cerebral oxygen extraction across different exercise intensities: Role of arterial PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_2}}}$

Experimental Physiology, EarlyView.
Abstract Stability in cerebral oxygen extraction fraction (OEF) is typically determined by alterations in cerebral blood flow (CBF). At rest, arterial partial pressure of carbon dioxide (PaCO2${P_{{\mathrm{aC}}{{\mathrm{O}}_2}}}$) and OEF exhibit a strong inverse relationship owing to the powerful influence of PaCO2${P_{{\mathrm{aC}}{{\mathrm{O}}_2}}}$
L. Madden Brewster, Travis Dylan Gibbons, Hannah Grace Caldwell, Connor A. Howe, Jennifer S. Duffy, Andrew R. Steele, Justin A. Monteleone, Jay M. J. R. Carr, Jodie Lauren Koep, Tenasia D. R. Monaghan, David B. MacLeod, Philip N. Ainslie   +11 more
wiley   +1 more source

Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery

Journal of Experimental & Clinical Cancer Research, 2019
Objective To investigate the lung cancer-promoting mechanism of mesenchymal stem cell-secreted extracellular vesicles (MSC-EV). Methods EV were isolated from culture media of human bone marrow-derived MSCs that were pre-challenged with or without hypoxia
Weihua Ren, Jianfeng Hou, Chenguang Yang, Hanjun Wang, Shuangting Wu, Yabin Wu, Xingpeng Zhao, Chao Lu   +7 more
doaj   +1 more source

Elevated carotid body tonic activity contributes to ventilatory acclimatization and de‐acclimatization to high altitude at rest and during exercise

The Journal of Physiology, EarlyView.
Abstract figure legend Participants spent 13 days at high altitude (3800 m), where the reduced inspired oxygen pressure (↓PiO2$ \downarrow {P_{{\mathrm{i}}{{\mathrm{O}}_2}}}$) which elicited ventilatory acclimatization and increased inhibition of ventilation by transient hyperoxia (ΔV̇E$\Delta {\dot V_{\mathrm{E}}}$).
Ayechew A. Getu, L. Madden Brewster, Travis D. Gibbons, James D. Anholm, Michael Stembridge, Philip N. Ainslie, Jay M. J. R. Carr   +6 more
wiley   +1 more source