Results 51 to 60 of about 41,916 (253)

Mutational fitness landscape of human influenza H3N2 neuraminidase

Cell Reports, 2023
Influenza neuraminidase (NA) has received increasing attention as an effective vaccine target. However, its mutational tolerance is not well characterized. Here, the fitness effects of >6,000 mutations in human H3N2 NA are probed using deep mutational scanning.
Ruipeng Lei, Andrea Hernandez Garcia, Timothy J.C. Tan, Qi Wen Teo, Yiquan Wang, Xiwen Zhang, Shitong Luo, Satish K. Nair, Jian Peng, Nicholas C. Wu   +9 more
openaire   +4 more sources

A Characterization and an Evolutionary and a Pathogenicity Analysis of Reassortment H3N2 Avian Influenza Virus in South China in 2019–2020

Viruses, 2022
Seasonal H3N2 influenza virus has always been a potential threat to public health. The reassortment of the human and avian H3N2 influenza viruses has resulted in major influenza outbreaks, which have seriously damaged human life and health. To assess the
Tengfei Liu, Yuhao Huang, Shumin Xie, Lingyu Xu, Junhong Chen, Wenbao Qi, Ming Liao, Weixin Jia   +7 more
doaj   +1 more source

Spread of antigenically drifted influenza A(H3N2) viruses and vaccine effectiveness in the United States during the 2018-2019 season.

Journal of Infectious Diseases, 2019
BACKGROUND Increased illness due to antigenically drifted A(H3N2) clade 3C.3a influenza viruses prompted concerns about vaccine effectiveness and vaccine strain selection. We used U.S.
B. Flannery, Rebecca J. Kondor, J. Chung, M. Gaglani, Michael Reis, R. Zimmerman, M. Nowalk, M. Jackson, L. Jackson, A. Monto, E. Martin, E. Belongia, H. McLean, Sara S Kim, L. Blanton, K. Kniss, Alicia P. Budd, L. Brammer, T. Stark, J. Barnes, D. Wentworth, A. Fry, Manish M Patel   +22 more
semanticscholar   +1 more source

Genetic content of Influenza H3N2 vaccine seeds

PLoS Currents, 2010
Influenza vaccine seeds produced in chicken eggs are selected through HA and NA surface glycoproteins antigenicity, as well as through high replicative ability. Here we characterize the genetic content of recently used thirteen H3N2 influenza vaccine seeds.
Bergeron, Corinne, Valette, Martine, Lina, Bruno, Ottmann, Michele   +3 more
openaire   +4 more sources

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance The majority of influenza vaccine antigens are prepared in chicken eggs. Human vaccine strains grown in eggs often possess adaptive mutations that increase viral attachment to chicken cells.
Seth J. Zost, Kaela Parkhouse, Megan E. Gumina, Kangchon Kim, Sebastian Diaz Perez, P. Wilson, J. Treanor, A. Sant, S. Cobey, S. Hensley   +9 more
semanticscholar   +1 more source

Evolution-informed forecasting of seasonal influenza A (H3N2) [PDF]

Science Translational Medicine, 2017
ABSTRACTInter-pandemic or seasonal influenza exacts an enormous annual burden both in terms of human health and economic impact. Incidence prediction ahead of season remains a challenge largely because of the virus’ antigenic evolution. We propose here a forecasting approach that incorporates evolutionary change into a mechanistic epidemiological model.
Du, Xiangjun, King, Aaron A., Woods, Robert J., Pascual, Mercedes   +3 more
openaire   +2 more sources

Seasonal influenza vaccination expands hemagglutinin-specific antibody breadth to older and future A/H3N2 viruses

npj Vaccines, 2022
History of influenza A/H3N2 exposure, especially childhood infection, shape antibody responses after influenza vaccination and infection, but have not been extensively studied.
Nina Urke Ertesvåg, Rebecca Jane Cox, Sarah Larteley Lartey, Kristin G-I Mohn, Karl Albert Brokstad, Mai-Chi Trieu   +5 more
doaj   +1 more source

Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin

Nature Communications
The receptor-binding site of influenza A virus hemagglutinin partially overlaps with major antigenic sites and constantly evolves. In this study, we observe that mutations G186D and D190N in the hemagglutinin receptor-binding site have coevolved in two ...
R. Lei, Weiwen Liang, Wenhao O. Ouyang, Andrea Hernandez Garcia, Chika Kikuchi, Shengyang Wang, Ryan McBride, Timothy J. C. Tan, Yuanxin Sun, Chunke Chen, Claire S. Graham, Lucia A. Rodriguez, Ivana R. Shen, Danbi Choi, Roberto Bruzzone, James C. Paulson, Satish K. Nair, C. K. Mok, Nicholas C. Wu   +18 more
semanticscholar   +1 more source

Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

bioRxiv, 2020
Seasonal influenza virus A/H3N2 is a major cause of death globally. Vaccination remains the most effective preventative. Rapid mutation of hemagglutinin allows viruses to escape adaptive immunity. This antigenic drift necessitates regular vaccine updates.
J. Huddleston, J. Barnes, T. Rowe, Xiyan Xu, Rebecca J. Kondor, D. Wentworth, L. Whittaker, B. Ermetal, R. Daniels, J. McCauley, Seiichiro Fujisaki, Kazuya Nakamura, N. Kishida, Shinji Watanabe, H. Hasegawa, I. Barr, K. Subbarao, R. Neher, T. Bedford   +18 more
semanticscholar   +1 more source

Clinico-Epidemiological Profile and Study of Influenza and Their Subtypes Among Suspected Influenza Patients in a Tertiary Care Teaching Hospital of Vadodara

GAIMS Journal of Medical Sciences
Background: Influenza viruses cause significant respiratory illness, with seasonal epidemics and occasional pandemics influenced by antigenic variation. Monitoring local prevalence and subtype distribution is vital for guiding public health responses.
Gulshan Chaudhary, Jigna Karia, Yash Khandelwal   +2 more
doaj   +1 more source