Results 71 to 80 of about 210,676 (190)

Estimating Influenza-associated Mortality in Korea: The 2009-2016 Seasons [PDF]

Journal of Preventive Medicine and Public Health, 2019
Objectives Estimating influenza-associated mortality is important since seasonal influenza affects persons of all ages, causing severe illness or death.
Kwan Hong, Sangho Sohn, Byung Chul Chun
doaj   +1 more source

Anti‐idiotypic antibodies as molecular mimics of conserved influenza hemagglutinin epitopes

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Broadly neutralizing antibodies (bNAbs) provide insights for developing universal influenza vaccines through their ability to neutralize diverse viral strains. However, designing antigens that reliably elicit bNAb responses remains challenging due to the difficulty in targeting conserved epitopes with a single antigen.
Hiroshi Itou, Kaori Sano, Akira Ainai, Kazushige Otsuki, Toshikazu Inoue, Takuya Hemmi, Hideki Hasegawa, Tadaki Suzuki   +7 more
wiley   +1 more source

Respiratory and systematic humoral and cellular immune response of pigs to a heterosubtypic influenza A virus infection [PDF]

, 2001
The level of heterosubtypic immunity (Het-I) and the immune mechanisms stimulated by a heterosubtypic influenza virus infection were investigated in pigs. Pigs are natural hosts for influenza virus and, like humans, they host both subtypes H1N1 and H3N2.
Heinen, P.P., Boer Luijtze, E.A., de, Bianchi, A.T.J.   +2 more
core  

Rapid evolution of the PB1-F2 virulence protein expressed by human seasonal H3N2 influenza viruses reduces inflammatory responses to infection [PDF]

, 2017
Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-length PB1-F2 proteins but during the 2010-2011 influenza seasons, nearly half of the circulating H3N2 IAVs encoded truncated
Yi-Mo Deng, Ian Barr, Mackenzie-Kludas, C, Lorena Brown, Charley Mackenzie-Kludas, McAuley, J, Julie McAuley, Deng, YM, Gilbertson, B, Barr, I, Brad Gilbertson, Brown, L   +11 more
core   +1 more source

Severity of heterosubtypic influenza virus infection in ferrets is reduced by live attenuated influenza vaccine

npj Vaccines, 2021
Live attenuated influenza vaccine (LAIV) is widely used to protect humans from seasonal influenza infection, particularly in children. In contrast to inactivated vaccines, the LAIV can induce both mucosal and cellular immune responses.
Anthony C. Marriott, Karen E. Gooch, Phillip J. Brown, Kathryn A. Ryan, Nicola J. Jones, Natasha Merredew, Nathan Wiblin, Oliver Dibben, Helen Bright, Bassam Hallis, Catherine J. Whittaker, Miles W. Carroll   +11 more
doaj   +1 more source

Duration and severity of asthma‐like episodes in young children vary by viral and bacterial triggers

Pediatric Allergy and Immunology, Volume 37, Issue 10, October 2026.
This study investigates how specific viral and bacterial triggers and age are associated with the duration and severity of asthma‐like episodes in children aged 0–3 years. Rhinovirus, particularly rhinovirus C, and the bacterial pathogens Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis were associated with longer episode ...
Julie Nyholm Kyvsgaard, Jonathan Thorsen, Signe Kjeldgaard Jensen, Tamo Sultan, Nicklas Brustad, Casper‐Emil Tingskov Pedersen, Anton Kjellberg, Thea K. Fischer, Karen A. Krogfelt, Nilo Vahman, James E. Gern, Ann‐Marie Malby Schoos, Klaus Bønnelykke, Bo Lund Chawes, Jakob Stokholm   +14 more
wiley   +1 more source

Molecular epidemiology survey and characterization of human influenza A viruses circulating among Palestinians in East Jerusalem and the West Bank in 2015.

PLoS ONE, 2019
Frequent typing and molecular characterization of influenza A (IAV) strains are crucial for the identification of circulating subtypes and for the selection of the subtypes' lineages to be included in the annually prepared vaccine cocktail.
Maysoon Bakri, Monjed Samuh, Maysa Azzeh
doaj   +1 more source

VIRUS-SPECIFIC HUMORAL IMMUNE RESPONSE ISOTYPIC STRUCTURE IN ADULT PATIENTS HOSPITALIZED WITH INFLUENZA A

Инфекция и иммунитет, 2016
The aim of this investigation was a comparative analysis of isotypic structure of specific antiviral systemic humoral immune response in hospitalized patients with influenza caused by virus A(H3N2) or A(H1N1), including the A(H1N1)pdm09. Paired acute and
V. Z. Krivitskaya, A. A. Vasilieva, E. M. Voytsekhovskaya, E. R. Petrova, M. M. Pisareva, Zh. V. Buzitskaya, E. A. Elpaeva, A. A. Go, L. V. Voloshchuk, N. I. Lvov, T. D. Smirnova, A. A. Sominina   +11 more
doaj   +1 more source

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, Volume 32, Issue 34, 11 September 2026.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source