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Immunogenicity, safety, and efficacy of the vaccine H56:IC31 in reducing the rate of tuberculosis disease recurrence in HIV-negative adults successfully treated for drug-susceptible pulmonary tuberculosis: a double-blind, randomised, placebo-controlled, phase 2b trial
The Lancet Infectious DiseasesPeople with tuberculosis who complete treatment remain at risk of recurrent disease. The vaccine H56:IC31 has been shown to be safe and immunogenic in phase 1 and 2 studies, but whether it can reduce the risk of tuberculosis recurrence is unknown.In a double-blind, randomised, placebo-controlled, phase 2b trial in South Africa (five clinical trial ...Álvaro H Borges, Marisa Russell, Dereck Tait, Thomas J Scriba, Elisa Nemes, Per Skallerup, Elana van Brakel, Andrea M Cabibbe, Daniela M Cirillo, Mildie Leuvennink-Steyn, Kathryn T Rutkowski, Grith K Wood, Birgit Thierry-Carstensen, Pernille N Tingskov, Emilie C Meldgaard, Max P Kristiansen, Rie E Søndergaard, Christian H Hansen, Frank Follmann, Charlotte G Jensen, Anele Gela, Nyanda E Ntinginya, Morten Ruhwald, Justin Shenje, Lisa White, Craig Innes, Pearl Selepe, Beatrice Ngaraguza, Chantelle Holmgren, Tarryn Collings, Peter Andersen, Rodney Dawson, Gavin Churchyard, Issa Sabi, Andreas H Diacon, Rasmus Mortensen, Mark Hatherill, Justin Shenje, Danelle Van As, Angelique Luabeya-Kanykany, Michele Tameris, Simon Mendelsohn, Nicolette Tredoux, Hennie Geldenhuys, Alessandro Companie, Sivuyile Buhlungu, Sonia Stryers, Miriam Moses, Veronica Baartman, Cynthia Gwintsa, Denis Arendsen, Habibullah Valley, Haydn Africa, Marcia Steyn, Simbarashe Mabwe, Johanna Van Rooyen, Angelique Mouton, Fajwa Opperman, Julia Noble, Thelma Leopeng, Humphrey Mulenga, Carmen Segelaar, Elizabeth Beyers, Denise Van der Westhuizen, Terence Esterhuizen, Asma Toefy, Mzwandile Erasmus, Yolundi Cloete, Lungisa Jaxa, Constance Schreuder, Onke Nombida, Rodney Raphela, Nicole Bilek, Cynthia Ontong, Ilse Davids, Margareth Erasmus, Christel Petersen, Rose Ockhius, Bongiwe Vasana, Mamosa Moleleki-Mabala, Sandisiwe Mangali, Hlengiwe Nkambule, Alida Carstens, Suzette Visagie, Phumzile Langafa, Elmien Verster, Rachel Oelofse, Rodney Dawson, Linda White, Frederico di Marco, Issa Sabi, Nyanda Elias Ntinginya, Beatrice Ngaraguza, Julieth Lalashowi, Ombeni Chimbe, Bariki Mtafya, Godlove Chaula, Emmanuel Sichone, Lwitiho Sudi, Abisai Kisinda, Revocatus Kunambi, Bahati Myombe, Simeon Mwanyonga, Cyprian Mtweve, Dereck Tait, Elana van Brakel, Maureen Lambrick, Fay Swanson, Kathryn Rutkowski, Devin Hunt, Anja van der Westhuizen, Heather Siefers, Leonie Coetzee, Mildie Leuvennink-Steyn, Deidre Albertyn, Marisa Russell, Viola-Marie Raubenheimer, Arrie van der Merwe, Aaliya Gangat, Adriane Kock, Amanda van Aswegen, Amukelani Dolly Nyathi, Aneesa Lakhi, Audrey Dlamini, Bertha Pei, Blossom Makhubalo, Candice Eyre, Craig Innes, Moeti Godfrey Serake, Pearl Selepe, Shirley Malefo-Grootboom, Elizabeth Barbara Janse van Rensburg, Hildah Ledwaba, Immaculate Mabasa, Juanita Market, Ken Clarke, Lawrence Ntoahae, Lebogang Isaac Tswaile, Letlhogonolo Seabela, Lezaan-Marie Erasmus, Lindiwe Nhlangulela, Mantai Makhetha, Marelize Collignon, Marietjie Zietsman, Maryna Nel, Mmanare Maria Tlhapi, Molly Majola, Moogo Fikizolo, Morongoenyane Josephine Motsiri, Mpho Makoanyane, Ndlela Israel Kunene, Nhlamulo Ndlovu, Nishanee Arjun, Nkosinathi Mabuza, Nondumiso Langa, Nontsikelelo Mbipha, Palesa Mosweu, Pearl Nomsa Sanyaka, Richard Nteleki, Samuel Mompati, Serame Sylvester Modipa, Tedrius Ntshauba, Thelma Goliath, Thompho Mugwena, Tshegofatso Mabe, Victor Rameetse, Vincent Tshikovhi, Welseh Phindile Galaive, Álvaro H Borges, Rasmus Mortensen, Per Skallerup, Birgit Thierry-Carstensen, Frank Follmann, Charlotte G Jensen, Pernille N Tingskov, Emilie C Meldgaard, Max P Kristiansen, Rebecca Bach Dohn, Rikke Dahl Bartholomæussen, Alida van Deventer, Hesti-Mari van Huyssteen, Carmen Kleinhans, Julia Sims, Monde Patientia, Thirumani Govender, Priscilla Samaai +185 moreopenaire +2 more sources
