Health Security: A Concept in Search of a Purpose
ABSTRACT Although the term “health security” is continuously gaining prominence and there are increasing calls to “strengthen” it, the term remains conceptually ambiguous. This ambiguity creates uncertainty about exactly what is being advanced in policy and practice when health security is invoked, and what consequences this has for priority‐setting in
Delaram Akhavein, Seye Abimbola
wiley +1 more source
Concurrent Acquisition of a Single Nucleotide Polymorphism in Diverse Influenza H5N1 Clade 2.2 Sub-clades [PDF]
Highly pathogenic Influenza A H5N1 was first identified in Guangdong Province in 1996, followed by human cases in Hong Kong in 1997. The number of confirmed human cases now exceeds 300, and the associated Case Fatality Rate exceeds 60%.
Moustafa M. Mansour +17 more
core +2 more sources
We describe the host response continuum for highly pathogenic avian influenza viruses (HPAIV), including the continuum of host responses to HPAIV infection and exposure based on the primary axis of host competence, ability to infect other hosts, and host vulnerability.
Johanna A. Harvey +9 more
wiley +1 more source
Discordant correlation between serological assays observed when measuring heterosubtypic responses against avian influenza H5 and H7 viruses in unexposed individuals [PDF]
The human population is constantly exposed to multiple influenza A subtypes due to zoonotic spill over and rapid viral evolution driven by intrinsic error-prone replication and immunological pressure.
Ferrara, Francesca +5 more
core +1 more source
ABSTRACT Human infection with or vaccination against influenza A virus has been one of the most informative systems for understanding how human antibody repertoires recognize viral glycoproteins. Decades of antibody isolation, repertoire sequencing, lineage tracing, serology, viral antigenic evolution, and structural biology have shown that antibody ...
Bruno Bonnettaz, Goran Bajic
wiley +1 more source
Epidemiology of the highly pathogenic avian influenza H5N1 in Northern Vietnam: Applications for surveillance and control [PDF]
The epidemiology and the sanitary situation of avian influenza changed dramatically with the emergence of the highly pathogenic H5N1 virus (HPAI) in 1996. As a consequence, knowledge previously accumulated on the epidemiology and the ecology of the avian
Desvaux, Stéphanie, Desvaux, S.
core
Avian, inter-pandemic, and pandemic influenza in Vietnam [PDF]
The burden and behaviour of influenza in Southeast Asia is poorly characterised, leading to uncertainty about the importance of influenza as a local health problem and the role of Southeast Asia in the global epidemiology of influenza.
Horby, Peter William
core +1 more source
Llama-Derived Single Domain Antibodies to Build Multivalent, Superpotent and Broadened Neutralizing Anti-Viral Molecules [PDF]
For efficient prevention of viral infections and cross protection, simultaneous targeting of multiple viral epitopes is a powerful strategy. Llama heavy chain antibody fragments (VHH) against the trimeric envelope proteins of Respiratory Syncytial Virus (
Schepens, B +94 more
core +1 more source
Testing of apathogenic influenza virus H5N3 as a poultry live vaccine
Four H5N2 experimental vaccine strains and the apathogenic wild duck H5N3 influenza virus A/duck/ Moscow/4182/2010 (dk/4182) were tested as a live poultry vaccine.
E. Y. Boravleva +7 more
doaj
The pandemic threat of an Avian Influenza Virus: An overview
The worst pandemic in modern history occurred during the 1918 H1N1 Spanish Influenza epidemic. Two additional instances of influenza A (H5N1) viral infection in humans have been disclosed to WHO in the West Pacific Zone between July 12 and July 18 ...
Amandeep Kaur +4 more
doaj +1 more source

