Results 131 to 140 of about 2,387 (153)

In vivo inhibition of NAS preparation on H9N2 subtype AIV

Virologica Sinica, 2010
NAS preparation, a kind of Chinese herbal medicine found by the Yunnan Eco-agricultural Research Institute, has potential antiviral activity. In this paper, the inhibiting effect of NAS preparation on H9N2 subtype Avian influenza virus (AIV) was investigated in vivo. Chickens infected with H9N2 virus were treated with NAS preparation for 4 days.
Jian-Ping Liang
exaly   +4 more sources

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Enhanced immune response of BMDCs pulsed with H9N2 AIV and CpG

Vaccine, 2014
Dendritic cells (DCs), professional antigen presenting cells, have demonstrated effective in controlling the initial of innate immune, while CpG could improve the performance of immune system. To explore the mechanism of CpG enhancing the immune response, we compared different stimulated mouse DCs with systemic approach microarrays.
, Jian Lin, Tao Qin
exaly   +3 more sources

Heterologous post-infection immunity against Egyptian avian influenza virus (AIV) H9N2 modulates the course of subsequent infection by highly pathogenic AIV H5N1, but vaccination immunity does not

Journal of General Virology, 2017
In Egypt, zoonotic A/goose/Guangdong/1/96 (gs/GD-like) highly pathogenic avian influenza virus (HPAIV) H5N1 of clade 2.2.1.2 is entrenched in poultry populations and has co-circulated with low-pathogenic avian influenza virus H9N2 of the G1 lineage since 2010. Here, the impact of H9N2 infection or vaccination on the course of consecutive infection with
Mahmoud Naguib, Martin Beer, Christian Grund   +2 more
exaly   +3 more sources

Chicken TCRγδ+CD8α+T cells are antigen-specific and protective in H9N2 AIV infection

Journal of Immunology
Abstract TCRγδ+ T cells are a major lymphocyte population of chickens, but their response or contribution to immunity against avian influenza virus (AIV) remains unknown. Here, we report an increase in the proportion and activation state of TCRγδ+CD8α+ T cells in the PBMCs of 3 chicken lines (MHC homozygous H-B2 and H-B21 lines and ...
Ming Liao, Adrian Lloyd Smith, Weisan Chen   +2 more
exaly   +3 more sources

Preparation and Antigenic Site Identification of Monoclonal Antibodies against PB1 Protein of H9N2 Subtype AIV

Veterinary Sciences
Recently, low pathogenic avian influenza virus (LPAIV), including H9N2 subtype, has been common clinical epidemic strains, and is widely distributed globally. The PB1 protein is a key component of the viral RNA polymerase complex (vRNP), and is vital to viral transcription and translation. In this study, to investigate the antigenic determinants in the
Xiuli Feng, Jianing Hu, Feng Xiuli
exaly   +4 more sources

KRT10 plays an important role in the release of viral genome from endosomes during H9N2 subtype AIV replication in HeLa cells

Veterinary Microbiology, 2023
The infection and replication of avian influenza virus (AIV) in host cells is a complex biological process that involves the transport of viral genes through the host cell's transport systems. Actin, microtubules and vimentin are known to facilitate transport of endosomes to the perinuclear region, but the biological role of Keratin, another ...
Xiangyu, Huang, Guihu, Yin, Bin, Zhou, Yiqin, Cai, Jianing, Hu, Jingwen, Huang, Zili, Chen, Qingtao, Liu, Xiuli, Feng   +8 more
openaire   +2 more sources

Revealing novel and conservative T-cell epitopes with MHC B2 restriction on H9N2 avian influenza virus (AIV)

Journal of Biological Chemistry
B2 haplotype major histocompatibility complex (MHC) has been extensively reported to confer resistance to various avian diseases. But its peptide-binding motif is unknown, and the presenting peptide is rarely identified. Here, we identified its peptide-binding motif (X-A/V/I/L/P/S/G-X-X-X-X-X-X-V/I/L) in vitro using Random Peptide Library-based MHC I ...
Ming Liao, Yongxiu Yao, Manman Dai
exaly   +3 more sources

GoTLR7 but not GoTLR21 mediated antiviral immune responses against low pathogenic H9N2 AIV and Newcastle disease virus infection

Immunology Letters, 2017
Aquatic birds are considered the biological and genetic reservoirs of avian influenza virus and play a critical role in the transmission and dissemination of Newcastle Disease Virus (NDV). Both TLR7 and TLR21 are important for the host antiviral immune response.
Bing, Yan, Jinyue, Zhang, Wei, Zhang, Mingshu, Wang, Renyong, Jia, Dekang, Zhu, Mafeng, Liu, Qiao, Yang, Ying, Wu, Kunfeng, Sun, Xiaoyue, Chen, Anchun, Cheng, Shun, Chen   +12 more
openaire   +2 more sources

Molecular identification and comparative transcriptional analysis of myxovirus resistance GTPase (Mx) gene in goose (Anser cygnoide) after H9N2 AIV infection

Comparative Immunology, Microbiology and Infectious Diseases, 2016
Interferon (IFN)-induced myxovirus resistance (Mx) GTPases belong to the family of dynamin-like GTPases and control a diverse range of viruses. In this study, the identified goose Mx (goMx) mRNA is 2009bp long, shares partially conserved exons with other homologues, and shares highly conserved domains in its primary structure.
Mingshu Wang, Anchun Cheng
exaly   +3 more sources

The host protein CCT8 interacts with PB2 protein of H9N2 AIV and facilitates virus replication

Avian Pathology
The host protein CCT8 interacts with the influenza virus protein PB2.The CCT8 gene is upregulated during influenza virus infection.Knockdown of CCT8 inhibits viral proliferation.Elevated expression of CCT8 facilitates viral proliferation.
Yiqin, Cai, Ye, Liu, Guihu, Yin, Jianing, Hu, Zichen, Gao, Xinyu, Guo, Ruiying, Wang, Meng, Zhong, Qingtao, Liu, Xiuli, Feng   +9 more
openaire   +2 more sources