Results 51 to 60 of about 139,282 (292)

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Life fingerprints of nuclear reactions in the body of animals [PDF]

, 2010
Nuclear reactions are a very important natural phenomenon in the universe. On the earth, cosmic rays constantly cause nuclear reactions. High energy beams created by medical devices also induce nuclear reactions in the human body.
Ci-yi Liu, Ji-hui Han, Ji-hui Su, Jun Zeng, Qi-yin Sun, Quan-shi Zhang, Tao Sun, Wen-hui Xie, Xiao-jia Cai   +8 more
core   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Assembly of mitochondria [PDF]

, 1980
The majority of mitochondrial proteins are synthesized on cytoplasmic ribosomes and transferred to the mitochondria where they are assembled to supramolecular structures.
Harmey, Matthew A., Neher, Eva-Maria, Neupert, Walter, Zimmermann, Richard   +3 more
core   +1 more source

Protein Kinase A-independent Activation of ERK and H,K-ATPase by cAMP in Native Kidney Cells

Journal of Biological Chemistry, 2002
This study aimed at determining the signaling pathways underlying calcitonin- and isoproterenol-induced stimulation of H,K-ATPase in rat renal collecting duct.
N. Laroche-Joubert, S. Marsy, S. Michelet, M. Imbert-Teboul, A. Doucet   +4 more
semanticscholar   +1 more source

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source

エンドウ原形質膜におけるATPアーゼとホスファチジルイノシトールリン資質リン酸化酵素の共精製 [PDF]

, 1999
The plasma membrance ATPase was partially purified by a linear glycerol density gradient centrifugation of the detergent-solubilized plasma membrance poteins and subsequent separation by a size-exclusion column chromatogrphy.
Ichinose, Yuki, Shiraishi, Tomonori, Toyoda, Kazuhiro, Yamada, Tetsuji   +3 more
core  

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Estrutura genética do pirarucu (Arapaima gigas) na região de Santarém, PA, Brasil. [PDF]

, 2013
O pirarucu (Arapaima gigas) é um peixe encontrado na Bacia Amazônica e Araguaia/Tocantins que possui grande importância econômica para populações locais.
ALMEIDA, I. G. de, CAETANO, A. R., FARIA, M. T. de, IANELLA, P., PAIVA, S. R.   +4 more
core  

Whole lifespan microscopic observation of budding yeast aging through a microfluidic dissection platform [PDF]

, 2012
Important insights into aging have been generated with the genetically tractable and short-lived budding yeast. However, it is still impossible today to continuously track cells by high-resolution microscopic imaging (e.g., fluorescent imaging ...
Barral, Charvin, Cookson, D. H. E. W. Huberts, Defossez, Falconnet, Finkel, Fontana, Gershon, Gordon, Henderson, I. A. Vizcarra, Kaeberlein, Kaeberlein, L. P. Lee, M. Heinemann, Madeo, Mortimer, M  ller, Powell, Rine, Ryley, S. S. Lee, Shcheprova, Shulewitz, Vanoni   +25 more
core   +5 more sources