Results 31 to 40 of about 139,282 (292)

Rapid method for determination of antimicrobial susceptibilities pattern of urinary bacteria [PDF]

, 1975
Method determines bacterial sensitivity to antimicrobial agents by measuring level of adenosine triphosphate remaining in the bacteria.
Barza, M. J., Chapelle, E. W., Picciolo, G. L., Tuttle, S. A., Vellend, H., Weinstein, L.   +5 more
core   +1 more source

Inhibition of gastric H+,K+-ATPase and acid secretion by SCH 28080, a substituted pyridyl(1,2a)imidazole.

Journal of Biological Chemistry, 1987
A hydrophobic amine, SCH 28080, 2-methyl-8-(phenylmethoxy)imidazo(1,2a)pyridine-3-acetonitrile, previously shown to inhibit gastric acid secretion in vivo and in vitro, was also shown to inhibit basal and stimulated aminopyrine accumulation in isolated ...
B. Wallmark, Carin BrivingS, Jan FryklundS, Keith MunsonQ, Raymond Jacksons, John MendleinQ, Edd RabonQ, George SachsQ   +7 more
semanticscholar   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deceleration of the E1P-E2P Transition and Ion Transport by Mutation of Potentially Salt Bridge-forming Residues Lys-791 and Glu-820 in Gastric H+/K+-ATPase*

Journal of Biological Chemistry, 2010
A lysine residue within the highly conserved center of the fifth transmembrane segment in PIIC-type ATPase α-subunits is uniquely found in H,K-ATPases instead of a serine in all Na,K-ATPase isoforms. Because previous studies suggested a prominent role of
Katharina L. Dürr, I. Seuffert, T. Friedrich   +2 more
semanticscholar   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Probing the Catalytic Roles of Arg548 and Gln552 in the Carboxyl Transferase Domain of the \u3cem\u3eRhizobium etli\u3c/em\u3e Pyruvate Carboxylase by Site-directed Mutagenesis [PDF]

, 2010
The roles of Arg548 and Gln552 residues in the active site of the carboxyl transferase domain of Rhizobium etli pyruvate carboxylase were investigated using site-directed mutagenesis.
Adina-Zada, Abdussalam, Attwood, Paul V., Byrne, Lindsay, Cleland, W. Wallace, Duangpan, Saowapa, Jitrapakdee, Sarawut, Maurice, Martin St., Wallace, John C., Zeczycki, Tonya N.   +8 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Biophysics at the coffee shop: lessons learned working with George Oster [PDF]

, 2019
Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerstone of biological inquiry.
Chen, Jing, Elston, Timothy C., Grabe, Michael, Igoshin, Oleg, Kim, Kenneth S., Liu, Jian, Nirody, Jasmine, Rangamani, Padmini, Sun, Sean, Wang, Hongyun, Wolgemuth, Charles, Xing, Jianhua   +11 more
core   +5 more sources

Role of H ⁺ /K ⁺ ‐ATPase and Na ⁺ /Ca ²⁺ exchangers in pancreatic ductal adenocarcinoma cells

The FASEB Journal, 2013
Pancreatic ductal adenocarcinoma (PDAC) has one of the worst cancer prognoses and a new initiative is to map the ion transportome to provide new therapeutic targets. Some of the hallmarks of cancer are increased glycolysis, altered H + and Ca 2 ...
Andrea Giannuzzo, Jing Wang, Else Kay Hoffman, Stine Helene Pedersen, Ivana Novak   +4 more
openaire   +1 more source