Results 91 to 100 of about 35,694,720 (305)

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Emission-line Stacking of 21 cm Intensity Maps with MeerKLASS: Inference Pipeline and Application to the L-band Deep-field Data

The Astrophysical Journal Supplement Series
We present a novel analysis of observational systematics through the emission-line stacking of the MeerKLASS L -band deep-field intensity maps, following the detection in MeerKLASS Collaboration et al.
Zhaoting Chen, Steven Cunnington, Alkistis Pourtsidou, Laura Wolz, Marta Spinelli, José Luis Bernal, Matilde Barberi-Squarotti, Stefano Camera, Isabella P. Carucci, José Fonseca, Keith Grainge, Melis O. Irfan, Mario G. Santos, Jingying Wang, (MeerKLASS Collaboration)   +14 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

21 cm Signal from the Thermal Evolution of Lyα during Cosmic Dawn

The Astrophysical Journal
The Ly α photons couple the spin temperature of neutral hydrogen (H I ) to the kinetic temperature during the era of cosmic dawn (CD). During this process, they also exchange energy with the medium, heating and cooling the H I .
Janakee Raste, Shiv K. Sethi
doaj   +1 more source

J-PLUS: Spectroscopic validation of Hα emission line maps in spatially resolved galaxies

Astronomy & Astrophysics
Aims. We present a dedicated automated pipeline to construct spatially resolved emission Hα+[NII] maps and to derive the spectral energy distributions (SEDs) in 12 optical filters (five broad and seven narrow and medium) of Hα emission line regions in nearby galaxies (z < 0.0165) observed by the Javalambre Photometric Local Universe Survey (J-PLUS).
P. T. Rahna, M. Akhlaghi, C. López-Sanjuan, R. Logroño-García, D. J. Muniesa, H. Domínguez-Sánchez, J. A. Fernández-Ontiveros, D. Sobral, A. Lumbreras-Calle, A. L. Chies-Santos, J. E. Rodríguez-Martín, S. Eskandarlou, A. Ederoclite, A. Alvarez-Candal, H. Vázquez Ramió, A. J. Cenarro, A. Marín-Franch, J. Alcaniz, R. E. Angulo, D. Cristóbal-Hornillos, R. A. Dupke, C. Hernández-Monteagudo, M. Moles, L. Sodré, J. Varela   +24 more
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Reconstruction of Cosmological Initial Density Field with Observations from the Epoch of Reionization

The Astrophysical Journal
The initial density distribution provides a basis for understanding the complete evolution of cosmological density fluctuations. While reconstruction in our local Universe exploits the observations of galaxy surveys with large volumes, observations of ...
Meng Zhou, Yi Mao
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source