Results 161 to 170 of about 4,605,994 (345)

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Sp1149. I. Constraints on the Balmer L–σ Relation for H ii Regions in a Spiral Galaxy at Redshift z = 1.49 Strongly Lensed by the MACS J1149 Cluster

The Astrophysical Journal
The luminosities ( L ) and velocity dispersions ( σ ) of the extinction-corrected Balmer emission lines of giant H ii regions in nearby galaxies exhibit a tight correlation (∼0.35 dex scatter).
Hayley Williams, Patrick Kelly, Wenlei Chen, Jose Maria Diego, Masamune Oguri, Alexei V. Filippenko   +5 more
doaj   +1 more source

A comprehensive study of reported high-metallicity giant H ii regions — I. Detailed abundance analysis [PDF]

, 2002
Marcelo Castellanos, Angeles I. Díaz, Elena Terlevich   +2 more
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

An Enigmatic PeVatron in an Area around H ii Region G35.6−0.5

The Astrophysical Journal
Identifying Galactic PeVatrons (PeV particle accelerators) from ultrahigh-energy (UHE, >100 TeV) γ -ray sources plays a crucial role in revealing the origin of Galactic cosmic rays.
Zhen Cao, F. Aharonian, Axikegu, Y. X. Bai, Y. W. Bao, D. Bastieri, X. J. Bi, Y. J. Bi, W. Bian, A. V. Bukevich, Q. Cao, W. Y. Cao, Zhe Cao, J. Chang, J. F. Chang, A. M. Chen, B. Q. Chen, E. S. Chen, H. X. Chen, Liang Chen, Lin Chen, Long Chen, M. J. Chen, M. L. Chen, Q. H. Chen, S. Chen, S. H. Chen, S. Z. Chen, T. L. Chen, Y. Chen, N. Cheng, Y. D. Cheng, M. C. Chu, M. Y. Cui, S. W. Cui, X. H. Cui, Y. D. Cui, B. Z. Dai, H. L. Dai, Z. G. Dai, Danzengluobu, X. Q. Dong, K. K. Duan, J. H. Fan, Y. Z. Fan, J. Fang, J. H. Fang, K. Fang, C. F. Feng, H. Feng, L. Feng, S. H. Feng, X. T. Feng, Y. Feng, Y. L. Feng, S. Gabici, B. Gao, C. D. Gao, Q. Gao, W. Gao, W. K. Gao, M. M. Ge, T. T. Ge, L. S. Geng, G. Giacinti, G. H. Gong, Q. B. Gou, M. H. Gu, F. L. Guo, J. Guo, X. L. Guo, Y. Q. Guo, Y. Y. Guo, Y. A. Han, O. A. Hannuksela, M. Hasan, H. H. He, H. N. He, J. Y. He, Y. He, Y. K. Hor, B. W. Hou, C. Hou, X. Hou, H. B. Hu, Q. Hu, S. C. Hu, C. Huang, D. H. Huang, T. Q. Huang, W. J. Huang, X. T. Huang, X. Y. Huang, Y. Huang, Y. Y. Huang, X. L. Ji, H. Y. Jia, K. Jia, H. B. Jiang, K. Jiang, X. W. Jiang, Z. J. Jiang, M. Jin, M. M. Kang, I. Karpikov, D. Khangulyan, D. Kuleshov, K. Kurinov, B. B. Li, C. M. Li, Cheng Li, Cong Li, D. Li, F. Li, H. B. Li, H. C. Li, Jian Li, Jie Li, K. Li, S. D. Li, W. L. Li, W. L. Li, X. R. Li, Xin Li, Y. Z. Li, Zhe Li, Zhuo Li, E. W. Liang, Y. F. Liang, S. J. Lin, B. Liu, C. Liu, D. Liu, D. B. Liu, H. Liu, H. D. Liu, J. Liu, J. L. Liu, M. Y. Liu, R. Y. Liu, S.M. Liu, W. Liu, Y. Liu, Y. N. Liu, Q. Luo, Y. Luo, H. K. Lv, B. Q. Ma, L. L. Ma, X. H. Ma, J. R. Mao, Z. Min, W. Mitthumsiri, H. J. Mu, Y. C. Nan, A. Neronov, K. C. Y. Ng, L. J. Ou, P. Pattarakijwanich, Z. Y. Pei, J. C. Qi, M. Y. Qi, B. Q. Qiao, J. J. Qin, A. Raza, D. Ruffolo, A. Sáiz, M. Saeed, D. Semikoz, L. Shao, O. Shchegolev, X. D. Sheng, F. W. Shu, H. C. Song, Yu. V. Stenkin, V. Stepanov, Y. Su, D. X. Sun, Q. N. Sun, X. N. Sun, Z. B. Sun, J. Takata, P. H. T. Tam, Q. W. Tang, R. Tang, Z. B. Tang, W. W. Tian, L. H. Wan, C. Wang, C. B. Wang, G. W. Wang, H. G. Wang, H. H. Wang, J. C. Wang, Kai Wang, Kai Wang, L. P. Wang, L. Y. Wang, P. H. Wang, R. Wang, W. Wang, X. G. Wang, X. Y. Wang, Y. Wang, Y. D. Wang, Y. J. Wang, Z. H. Wang, Z. X. Wang, Zhen Wang, Zheng Wang, D. M. Wei, J. J. Wei, Y. J. Wei, T. Wen, C. Y. Wu, H. R. Wu, Q. W. Wu, S. Wu, X. F. Wu, Y. S. Wu, S. Q. Xi, J. Xia, G. M. Xiang, D. X. Xiao, G. Xiao, Y. L. Xin, Y. Xing, D. R. Xiong, Z. Xiong, D. L. Xu, R. F. Xu, R. X. Xu, W. L. Xu, L. Xue, D. H. Yan, J. Z. Yan, T. Yan, C. W. Yang, C. Y. Yang, F. Yang, F. F. Yang, L. L. Yang, M. J. Yang, R. Z. Yang, W. X. Yang, Y. H. Yao, Z. G. Yao, L. Q. Yin, N. Yin, X. H. You, Z. Y. You, Y. H. Yu, Q. Yuan, H. Yue, H. D. Zeng, T. X. Zeng, W. Zeng, M. Zha, B. B. Zhang, F. Zhang, H. Zhang, H. M. Zhang, H. Y. Zhang, J. L. Zhang, Li Zhang, P. F. Zhang, P. P. Zhang, R. Zhang, S. B. Zhang, S. R. Zhang, S. S. Zhang, X. Zhang, X. P. Zhang, Y. F. Zhang, Yi Zhang, Yong Zhang, B. Zhao, J. Zhao, L. Zhao, L. Z. Zhao, S. P. Zhao, X. H. Zhao, F. Zheng, W. J. Zhong, B. Zhou, H. Zhou, J. N. Zhou, M. Zhou, P. Zhou, R. Zhou, X. X. Zhou, X. X. Zhou, B. Y. Zhu, C. G. Zhu, F. R. Zhu, H. Zhu, K. J. Zhu, Y. C. Zou, X. Zuo, (The LHAASO Collaboration)   +299 more
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

IRAS 16475–4609: A Young Compact H II Region Sculpting its Molecular Environment

The Astronomical Journal
We present a near-infrared spectroscopic and imaging analysis of the star-forming region IRAS 16475−4609, based on TripleSpec/SOAR spectroscopy and NEWFIRM/CTIO imaging, complemented by archival radio and submillimeter data.
Felipe Navarete, Sean D. Points, Augusto Damineli   +2 more
doaj   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Consistent Gas-phase C/O Abundances from UV and Optical Emission Lines: A Robust Scale for Chemical Evolution across Cosmic Time

The Astrophysical Journal
The carbon-to-oxygen (C/O) abundance ratio is a valuable tracer of star formation history, as C and O enrichment occurs on different timescales. However, measurements based on ultraviolet (UV) collisionally excited lines and those based on optical ...
Paige M. Kelly, Tucker Jones, Yuguang Chen, Ryan L. Sanders, Danielle A. Berg, Peter Senchyna, Fabio Bresolin, Daniel Stark   +7 more
doaj   +1 more source