Results 71 to 80 of about 1,149,495 (269)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Galactic H II Regions in the LAMOST Medium-Resolution Spectroscopic Survey of Nebulae
The Astronomical JournalBased on LAMOST Medium-Resolution Spectroscopic Survey of Nebulae (MRS-N) data and the Wide-field Infrared Survey Explorer Galactic H II region catalog, we construct a sample of 280 Galactic H II regions and candidates in the outer Galaxy (80° ≲ l ...
Yunning Zhao +12 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Astrophysical JournalWe present the variations in far-ultraviolet (FUV) and H α star formation rates (SFR), SFR _UV and SFR _H _α , respectively, at subkiloparsec scales in 11 galaxies as part of the Deciphering the Interplay between the Interstellar Medium, Stars, and the ...
Mansi Padave +5 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
The First Empirical Calibration of the Mid-infrared Abundance Diagnostic Ne23 with JWST
The Astrophysical Journal LettersLarge surveys of galaxies in the local and high-redshift Universe have, traditionally, relied on the intensity of rest-optical emission lines from metal ions in the interstellar medium (ISM) to indirectly estimate the O/H abundance in the gas.
Noah S. J. Rogers +12 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
The Astrophysical Journal, 1982 Observations of the molecular gas surrounding the biconical H II region S106 reveal a approx.100 M/sub sun/ disk constraining the development of the ionized region. Two CO peaks are seen in the equatorial plane of the biconical nebula on opposite sides of a near infrared source thought to be the exciting star for the H II region. Although no systematic
J. Bally, N. Z. Scoville
openaire +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source