Results 91 to 100 of about 3,875,215 (299)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The Coevolution of Stellar Wind-blown Bubbles and Photoionized Gas. I. Physical Principles and a Semianalytic Model

open access: yesThe Astrophysical Journal
We propose a new framework for the simultaneous feedback of stellar winds and photoionizing radiation from massive stars, distinguishing the locations where forces are applied, and consequences for internal spatiotemporal evolution of the whole feedback ...
Lachlan Lancaster   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Absorption and Self-absorption of [C ii] and [O i] Far Infrared Lines toward a Bright Bubble in the Nessie Infrared Dark Cloud

open access: yesThe Astrophysical Journal
Using the upGREAT instrument on board the Stratospheric Observatory for Infrared Astronomy, we imaged [C ii ] 157.74 and [O i ] 63.18 μ m line emission from a bright photodissociation region (PDR) associated with an ionized bubble located in the Nessie ...
James M. Jackson   +17 more
doaj   +1 more source

Infrared emission from ultracompact H II regions [PDF]

open access: yes
Models of circumstellar dust shells around ultracompact (UC) H II regions were constructed that accurately fit the observed IR flux distributions. The models assume spherically symmetric dust shells illuminated by stars whose bolometric luminosity is ...
Churchwell, ED   +2 more
core   +1 more source

Magnetic field in Cepheus A as deduced from OH maser polarimetric observations

open access: yes, 2005
We present the results of MERLIN polarization mapping of OH masers at 1665 and 1667 MHz towards the Cepheus A star-forming region. The maser emission is spread over a region of 6 arcsec by 10 arcsec, twice the extent previously detected.
Bartkiewicz, A.   +3 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Low-mass Stellar and Substellar Content of the Young Cluster Berkeley 59

open access: yesThe Astronomical Journal
We present a multiwavelength analysis of the young star cluster Berkeley 59, based on Gaia data and deep IR observations with the 3.58 m Telescopio Nazionale Galileo and Spitzer space telescope.
Neelam Panwar   +6 more
doaj   +1 more source

Reddening and extinction towards H II regions [PDF]

open access: yes
The light emitted by the gas in H II regions is attenuated by dust. This extinction can be measured by comparing H alpha, H beta, and radio continuum fluxes, since the intrinsic ratios of the Balmer line and thermal radio continuum emissivities are ...
Caplan, James, Deharveng, Lise
core   +1 more source

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