Results 91 to 100 of about 1,149,495 (269)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Magnetic Field Alignment Relative to Multiple Tracers in the High-mass Star-forming Region RCW 36
The Astrophysical JournalWe use polarization data from SOFIA HAWC+ to investigate the interplay between magnetic fields and stellar feedback in altering gas dynamics within the high-mass star-forming region RCW 36, located in Vela C.
Akanksha Bij +11 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Detection of Diffuse Hot Gas around the Young, Potential Superstar Cluster H72.97–69.39
The Astrophysical JournalWe present the first Chandra X-ray observations of H72.97–69.39, a highly embedded, potential superstar cluster in its infancy located in the star-forming complex N79 of the Large Magellanic Cloud. We detect particularly hard, diffuse X-ray emission that
Trinity L. Webb +8 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Investigating H II Regions in the Disk of NGC 7331 with the Circumgalactic Hα Spectrograph
The Astrophysical JournalWe investigate the ionized gas kinematics of H ii regions in the disk of NGC 7331 using integral field unit data collected with the Circumgalactic H α Spectrograph (CH α S).
Nazende ipek Kerkeser +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
The Astrophysical JournalThe kinematic evolution of hypercompact (HC) H ii regions around young high-mass stars remains poorly understood due to complex interactions with parental environs.
Siju Zhang +21 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Spectroscopy of Supernova Remnants and Candidates in M31
The Astrophysical JournalWith a star formation rate of order 0.4 M _⊙ yr ^−1 , M31 should have a significant population of supernova remnants (SNRs) and, in fact, 156 SNRs and SNR candidates have been suggested by J. H. Lee & M. G.
Nelson Caldwell +3 more
doaj +1 more source