Results 61 to 70 of about 5,241 (198)

Red lines and green lights: Gene therapy for inherited erythroid disorders beyond the haemoglobinopathies

British Journal of Haematology, EarlyView.
Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi, Nandakumar Natarajan, Kathryn E. Dickerson, Richard A. Voit   +3 more
wiley   +1 more source

Haemoglobinopathies in Referred Cases for Haemoglobin Electrophoresis in a Tertiary Care Teaching Hospital

Journal of Rawalpindi Medical College, 2019
BACKGROUND: Haemoglobinopathies can be quantitative (thalassemic syndromes) or qualitative (Hb variants). Haemoglobinopathies are the most common genetic defect globally.
Maha Tariq, Qandeel Zafar, Warda Waheed, Atifa Shuaib, Javeria Qaiser, Muhammad Nauman Malik   +5 more
doaj  

Smartphone‐Based Teledentistry to Support Clinical Triage and Risk‐Informed Dental Care in Patients With Inherited Bleeding and Haemoglobin Disorders: A Cross‐Sectional Diagnostic Agreement Study

Haemophilia, EarlyView.
ABSTRACT Introduction Patients with inherited bleeding and haemoglobin disorders face barriers to accessing timely dental care, increasing the risk of untreated oral disease and complications related to invasive procedures. Aim To evaluate the agreement between smartphone‐based asynchronous teledentistry and face‐to‐face examination for oral conditions,
Victor Cordeiro da Silva, Carolina Mendes Frusca do Monte, Leandro Tavares da Silva, Gabriela Silva Almeida, Claudia Santos Lorenzato, José Vitor Nogara Borges de Menezes, Fabian Calixto Fraiz, Cassius Carvalho Torres‐Pereira   +7 more
wiley   +1 more source

Prevalence, Severity, and Morphological Patterns of Anaemia Among Tribal Children and Adolescents in Chhotaudepur District, Gujarat: A Community-Based Cross-Sectional Study

GAIMS Journal of Medical Sciences
Background: Anaemia disproportionately affects tribal populations in India due to nutritional deficiencies, haemoglobinopathies, and limited healthcare access. Community-level data from tribal districts of Gujarat are lacking.
Mukundkumar Vaja, Pooja Patel, Dipika Bhil, Tirth Solanki, Hitul Patel, Chetan Chowdary, Jinal Mehta   +6 more
doaj   +1 more source

Iron in haemoglobinopathies and rare anaemias

Thalassemia Reports, 2014
Iron overload in haemoglobinopathies and rare anaemias may develop from increased iron absorption secondary to hepcidin suppression, and/or from repeated blood transfusions.
John Porter
doaj   +1 more source

Characterizing Red Blood Cell Rheological Parameters Using Automated Syllectometry: Conventional and Exploratory Multivariate Analyses

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Red blood cell (RBC) biomechanics are key determinants of blood rheology, microcirculatory flow, and tissue oxygen delivery, yet remain underutilized in clinical practice because of methodological variability and limited standardization.
Baran Dastaran, Yousra Tera, Maica Jhiezl Yunon, Maha Othman   +3 more
wiley   +1 more source

Haemoglobinopathies in Europe: health & migration policy perspectives [PDF]

, 2018
BACKGROUND: Major haemoglobinopathies (MH), such as thalassaemia syndromes (Thal) and sickle cell disorders (SCD), are genetic defects associated with chronic anaemia and other complications.
Petrova-Benedict, Roumyana, Aguilar Martinez, Patricia, Vives i Corrons, Joan Lluís, Eleftheriou, Androulla, Angastiniotis, Michael, Mañú Pereira, María del Mar, Gulbis, Beatrice   +6 more
core   +1 more source

Differentiating β‐Thalassaemia From Iron Deficiency: Performance and Cut‐Off Dependency of More Than 40 Red Cell Discrimination Indices in a Large German Cohort

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Since the 1970s, more than 40 red blood cell–based formulas have been proposed to differentiate β‐thalassaemia trait (BTT) from iron deficiency (ID) and iron deficiency anaemia (IDA), the main causes of microcytic anaemia. In Germany, where haemoglobinopathies are rare in the autochthonous population but increasingly encountered due
Rafid Al‐Nabhan, Dani Hakimeh, Lena Oevermann   +2 more
wiley   +1 more source

Screening for haemoglobinopathies on cord blood: laboratory and clinical experience.

, 2012
Blood from the umbilical cord (cord blood) is screened for haemoglobinopathies in several neonatal screening programmes, as well as before banking as a source of stem cells.
Gulbis, Béatrice, Cotton, Frédéric, Wolff, Fleur   +2 more
core   +1 more source

Refining Residual Ischemic Stroke Risk in Anticoagulated Atrial Fibrillation Using Index Outpatient LA Diameter: The CHA2DS2‐VALa Score

Journal of Cardiovascular Electrophysiology, EarlyView.
In anticoagulated atrial fibrillation, residual ischemic stroke risk persists despite guideline‐directed therapy. In this single‐center cohort, an enlarged index outpatient left atrial diameter independently predicted stroke and improved risk stratification when added to CHA2DS2‐VA (CHA2DS2‐VALa), supporting a simple, clinically implementable ...
Sefa Erdi Ömür, Emin Koyun, Gülşen Genç Tapar, Kayıhan Karaman, Metin Karayakali, Ataç Çelik, Uğur Kulu, Yasin Taşkin   +7 more
wiley   +1 more source