Results 81 to 90 of about 5,241 (198)

Detection of complex hemoglobinopathies: recommendations on screening and DNA testing

Thalassemia Reports, 2011
The following recommendations should be taken into account during the evaluation and elucidation of the complex hemoglobinopathies: a) in complex hemoglobinopathies performing DNA studies on all family members might be essential; b) complex gene-gene ...
E. Baysal
doaj   +1 more source

Improvement of Sickle Cell Disease Care Mitigates the Healthcare Utilization Induced by Increased Prevalence: Experience of a Tertiary Pediatric Center

Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
ABSTRACT Background Sickle cell disease (SCD) has undergone major changes in the last decades. Its prevalence has been steadily increasing and numerous advances have been made in the management of the disease. However, the effect in real‐life setting of these major changes is unknown, particularly in a Canadian environment. Procedure We aimed to assess
Maude Cigna, Alexia Muresan, Estelle Lecluze, Karine Leduc, Nathalie Fournier, Maria Tamer, Jean‐François Delisle, Jeremi Charbonneau, Annie Viau, Jessica Darilus, Marie‐Joëlle Doré‐Bergeron, Valérie Arsenault, Evelyne Doyon‐Trottier, Stéphanie Forte, Nancy Robitaille, Yves Pastore, Thomas Pincez   +16 more
wiley   +1 more source

The Role of Ferroptosis Induced by Iron Overload in Osteoblast and Osteoclast Function

Cell Biology International, Volume 50, Issue 10, October 2026.
ABSTRACT Iron overload disrupts bone homeostasis by suppressing osteoblast survival and mineralization, while promoting osteoclastogenesis. As a programmed cell death driven by iron‐dependent lipid peroxidation and glutathione peroxidase 4 (GPX4) downregulation. This study investigated the role of ferroptosis in bone cells under iron overload. Exposure
Supagarn Sooksawanwit, Kornkamon Lertsuwan, Natnicha Tannop, Ploypapus Lapatkeattisukul, Thanayuth Jenpichitkulchai, Nittiyaporn Sotapong, Jarinthorn Teerapornpuntakit, Tueanjai Khunluck, Siriwan Punvilai, Narattaphol Charoenphandhu   +9 more
wiley   +1 more source

The role of the clinical nurse specialist in haemoglobinopathies [PDF]

, 2018
The role of the Clinical Nurse Specialist (CNS) is an everdeveloping role that is integral in the care of individuals with haemoglobinopathies. Haemoglobinopathies are complex disorders that require specialist knowledge to deliver the very best care.
Bernadette Hylton
core   +1 more source

Antenatal screening for haemoglobinopathies in primary care: a cohort study and cluster randomised trial to inform a simulation model. The Screening for Haemoglobinopathies in First Trimester (SHIFT) trial

Health Technology Assessment, 2010
Objectives: To assess the effectiveness, cost-effectiveness, acceptability and feasibility of offering universal antenatal sickle cell and thalassaemia (SCT) screening in primary care when pregnancy is first confirmed and to model the cost-effectiveness ...
E Dormandy, S Bryan, MC Gulliford, TE Roberts, AE Ades, M Calnan, K Atkin, J Karnon, PM Barton, J Logan, F Kavalier, HJ Harris, TA Johnston, EN Anionwu, V Davis, K Brown, A Juarez-Garcia, V Tsianakas, TM Marteau   +18 more
doaj   +1 more source

Multisystem Complications in Non‐Transfusion‐Dependent β‐Thalassemia Intermedia: A Case Highlighting the Need for Early Intervention

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT This case highlights that severe complications of non‐transfusion‐dependent β‐thalassemia may be preventable with appropriate monitoring and timely intervention; however, once established, multisystem complications can be challenging to treat.
Oldooz Aloosh, Seyedeh Esmat Hosseini, Mohammad Karimi   +2 more
wiley   +1 more source

Haemoglobinopathies and resistance to malaria.

, 2003
The haemoglobinopathies have a celebrated role in the study of human genetics as the first examples of balanced polymorphisms described in human populations.
Thomas N. Williams, Williams, TN, Williams, Thomas, David J. Roberts, Roberts, DJ   +4 more
core   +1 more source

1st Pan-Asian Conference on Haemoglobinopathies, 8-10 February 2012 Bangkok - Thailand [PDF]

, 2012
This abstract book contains all abstracts presented to the 1st Pan-Asian Conference on Haemoglobinopathies, 8-10 February 2012 Bangkok ...
Thalassaemia international Federation, Thalassaemia Foundation of Thailand and Mahidol University
core   +1 more source

Genetic screening and haemoglobinopathies: ethics, politics and practice

, 1998
The increasing availability of information on the human genetic makeup presents both individuals and society with difficult decisions. This paper explores the ethical and practical issues raised by genetic screening for sickle cell and thalassaemia major,
Atkin, K., Ahmad, W.
core   +3 more sources

Evaluating Reproductive Health Recommendations in CPGs for Sickle Cell Disease: An Umbrella Review

Clinical and Public Health Guidelines, Volume 3, Issue 4, October 2026.
ABSTRACT Background Individuals with sickle cell disease or trait (SCD/T) face significant reproductive health risks, highlighting the need to assess the best available evidence on their reproductive health needs. Objectives To assess the quality of SCD/T clinical practice guidelines and evaluate the key characteristics and quality of their ...
Lisa R. Roberts, Marc Julmisse, Safiye Sahin, Jan M. Nick, Shanalee Tamares   +4 more
wiley   +1 more source