Results 21 to 30 of about 22,513 (247)
Haemophilia A and haemophilia B: molecular insights [PDF]
Molecular Pathology, 2002 This review focuses on selected areas that should interest both the scientist and the clinician alike: polymorphisms within the factor VIII and factor IX genes, their linkage, and their ethnic variation; a general assessment of mutations within both genes and a detailed inspection of the molecular pathology of certain mutations to illustrate the ...
openaire +4 more sources
Atypical Presenting Symptoms of Acute Onset Acquired Haemophilia with Eosinophilic Fasciitis
European Journal of Case Reports in Internal Medicine, 2020 Acquired haemophilia is a bleeding disorder caused by antibodies against coagulation factors. Some cases are associated with autoimmune diseases. However, no cases of acquired haemophilia with eosinophilic fasciitis have been previously reported.
Yuto Nakakubo +2 more
doaj +1 more source
''Sickle cell trait and haemophilia: a rare association''
The Pan African Medical Journal, 2018 In this paper we analyze the combination of HbAS disease and haemophilia A must be exceedingly rare. Because of this rarity we report the case of two brothers with sickle cell trait and major haemophilia A.
Hayat El Maataoui +2 more
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Orphanet Journal of Rare Diseases, 2022 Background Gene therapy has the potential to change the life experience of people with haemophilia and family members. Few studies have sought to explore the impact of gene therapy on both individuals and families.
Simon Fletcher +4 more
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The inhibitors – a challenge for the management of patients with hereditary haemophilia A
Romanian Journal of Internal Medicine, 2018 Introduction. Our research strategy was aimed at evaluating the possible implication of the type of factor VIII product administered as substitution treatment to haemophilia A patients in the occurrence of inhibitors and their consequences on the ...
Mihăilă Romeo-Gabriel
doaj +1 more source
Causes of death and mortality trends related to hemophilia in Brazil, 1999 to 2016
Hematology, Transfusion and Cell Therapy, 2021 Introduction: Multiple cause of death methodology enhances mortality studies beyond the traditional underlying cause of death approach. Aim: This study aims to describe causes of death and mortality issues related to haemophilia with the use of multiple ...
Augusto Hasiak Santo
doaj +1 more source
Polish Archives of Internal Medicine, 2007 Acquired haemophilia (AH) is a severe bleeding diathesis that affects both males and females. It is caused by suddenly appearing autoantibodies that interfere with coagulation factor VIII (FVIII) activity. Although some conditions such as autoimmune diseases, cancer and puerperium seem likely to induce AH, in more than half of the observed cases ...
Anna, Buczma, Jerzy, Windyga
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Evolution of congenital haemophilia care in Taiwan
Journal of the Formosan Medical Association, 2022 Haemophilia care in Taiwan has come a long way over the past 35 years, from the absence of specialised haemophilia treatment centres before 1984 to the establishment of treatment centers in the majority of medical centers, the listing of haemophilia as a
Yeu-Chin Chen +6 more
doaj +1 more source
British Journal of Haematology, 2018 SummaryAdvances in the development of effective and safe treatments for haemophilia over the last 50 years have resulted in a significant increase in the life expectancy of persons with haemophilia (PWH). The management of this new cohort of middle‐aged and elderly PWH is challenging because of the opposing risks of haemophilia and age‐related ...
Shapiro, S., Makris, M.
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Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing
Animal Research and One Health, EarlyView.Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley +1 more source